The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Gut Microbiota and Intestinal Trans-Epithelial Permeability
Open accessAbstract
Constant remodeling of tight junctions to regulate trans-epithelial permeability is essential in maintaining intestinal barrier functions and thus preventing diffusion of small molecules and bacteria to host systemic circulation. Gut microbiota dysbiosis and dysfunctional gut barrier have been correlated to a large number of diseases such as obesity, type 2 diabetes and inflammatory bowel disease. This led to the hypothesis that gut bacteria-epithelial cell interactions are key regulators of epithelial permeability through the modulation of tight junctions. Nevertheless, the molecular basis of host-pathogen interactions remains unclear mostly due to the inability of most in vitro models to recreate the differentiated tissue structure and components observed in the normal intestinal epithelium. Recent advances have led to the development of a novel cellular model derived from intestinal epithelial stem cells, the so-called organoids, encompassing all epithelial cell types and reproducing physiological properties of the intestinal tissue. We summarize herein knowledge on molecular aspects of intestinal barrier functions and the involvement of gut bacteria-epithelial cell interactions. This review also focuses on epithelial organoids as a promising model for epithelial barrier functions to study molecular aspects of gut microbiota-host interaction.
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Cites
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High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review
Malesza, I. J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., & Mądry, E. (2021) · Cells · doi:10.3390/cells10113164 · Cited by 782
Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 403
Shedding light on the impacts of Spirulina platensis on gut microbiota and related health benefits
Alves, J. L. D. B., Costa, P. C. T. D., Sales, L. C. S. D., Silva Luis, C. C., Bezerra, T. P. T., Souza, M. L. A., Costa, B. A., & de Souza, E. L. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2323112 · Cited by 21
Metadata
- Authors
- Allam-Ndoul, B., Castonguay-Paradis, S., & Veilleux, A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-09-03
- Volume
- 21
- Issue
- 17
- Pages
- 6402
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3082866225
- Cited by
- 351
- References
- 104
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- gold
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- Allam-Ndoul, B., Castonguay-Paradis, S., & Veilleux, A. (2020). Gut Microbiota and Intestinal Trans-Epithelial Permeability. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21176402
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
