The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment
Open accessAbstract
Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting immunoregulation via controlling the activation, proliferation, and apoptosis of immunocytes. In cancer, it plays a critical role in tumor microenvironment (TME) for accelerating invasion, metastasis, angiogenesis, and immunosuppression. Increasing evidence suggest a pleiotropic nature of TGF-β signaling as a critical pathway for generating fibrotic TME, which contains numerous cancer-associated fibroblasts (CAFs), extracellular matrix proteins, and remodeling enzymes. Its pathogenic roles and working mechanisms in tumorigenesis are still largely unclear. Importantly, recent studies successfully demonstrated the clinical implications of fibrotic TME in cancer. This review systematically summarized the latest updates and discoveries of TGF-β signaling in the fibrotic TME.
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Citations
Cites
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1×
“TGF-β is also crucial for activating cancer-associated fibroblasts (CAFs) to modulate migration and invasion of the cancer cells [63,64].”
BackgroundOrimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
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Microenvironmental regulation of tumour angiogenesis
De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847 · cited 1×
“Angiogenesis is important to ensure a continuous supply of essential nutrients and oxygen for cancer cells via expression of various pro-angiogenic factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2), fibroblast activation protein (FAP), and chemokine 12 (CXC12), which are mai…”
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“CAFs mediate migration and invasion of the cancer cells via altering the architecture of TME by various actions, including secretion of ECM (fibronectin and collagen type I, II), growth factors and cytokines (such as TGF-β, HGF, FGF, CXCL12, CCL2, CCL5, CCL7, CXCL16, and IL-6) [81–83], generation of escaping paths (vi…”
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Macrophages: versatile players in renal inflammation and fibrosis
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Self-citationFibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis
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Cited by
TGF-β signaling networks in the tumor microenvironment
Chan, M. K.-K., Chung, J. Y.-F., Tang, P. C.-T., Chan, A. S.-W., Ho, J. Y.-Y., Lin, T. P.-T., Chen, J., Leung, K.-T., To, K.-F., Lan, H.-Y., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215925 · Cited by 90
Self-citationLu, X., Zhang, J.-X., Zhang, L., Wu, D., Tian, J., Yu, L.-J., He, L., Zhong, S., Du, H., Deng, D.-F., et al. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156571 · Cited by 65
Duan, S., Sun, F., Qiao, P., Zhu, Z., Geng, M., Gong, X., Li, Y., & Yao, H. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01179 · Cited by 23
Metadata
- Authors
- Chung, J. Y.-F., Chan, M. K.-K., Li, J. S.-F., Chan, A. S.-W., Tang, P. C.-T., Leung, K.-T., To, K.-F., Lan, H.-Y., & Tang, P. M.-K.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-07-15
- Volume
- 22
- Issue
- 14
- Pages
- 7575
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3181934357
- Cited by
- 200
- References
- 20
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chung, J. Y.-F., Chan, M. K.-K., Li, J. S.-F., Chan, A. S.-W., Tang, P. C.-T., Leung, K.-T., To, K.-F., Lan, H.-Y., & Tang, P. M.-K. (2021). TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22147575
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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