On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153
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The Bdnf (brain-derived neurotrophic factor) gene contains eight regulatory exons (I–VIII) alternatively spliced to the protein-coding exon IX. Only exons I, II, IV, and VI are relatively well studied. The BDNF system and brain serotonergic system are tightly interconnected and associated with aggression. The benzopentathiepine TC-2153 affects both systems and exerts antiaggressive action. Our aim was to evaluate the effects of TC-2153 on the Bdnf exons I–IX’s expressions and serotonin receptors’ mRNA levels in the brain of rats featuring high aggression toward humans (aggressive) or its absence (tame). Aggressive and tame adult male rats were treated once with vehicle or 10 or 20 mg/kg of TC-2153. mRNA was quantified in the cortex, hippocampus, hypothalamus, and midbrain with real-time PCR. Selective breeding for high aggression or its absence affected the serotonin receptors’ and Bdnf exons’ transcripts differentially, depending on the genotype (strain) and brain region. TC-2153 had comprehensive effects on the Bdnf exons’ expressions. The main trend was downregulation in the hypothalamus and midbrain. TC-2153 increased 5-HT1B receptor hypothalamusc mRNA expression. For the first time, an influence of TC-2153 on the expressions of Bdnf regulatory exons and the 5-HT1B receptor was shown, as was an association between Bdnf regulatory exons and fear-induced aggression involving genetic predisposition.
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In Novosibirsk, Russia, a research group has bred 90 generations of gray Norway rats selectively for either tameness or high aggression towards a human experimenter's hand.
“In Novosibirsk, Russia, a research group has bred 90 generations of gray Norway rats selectively for either tameness or high aggression towards a human experimenter’s hand (Moskaliuk et al. 2023).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Moskaliuk et al. 2023
The Introduction and Materials and Methods §4.1 state that wild Norway rats were selectively bred for 90 generations in Novosibirsk for absence or enhancement of aggression toward humans. Our copy does not specify that selection was based on responses to an experimenter’s hand. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThese selectively bred lines display distinct behavioral phenotypes and differences in relevant neurobiology like monoamine systems.
“These lines not only display distinct behavioral phenotypes, but also differences in relevant neurobiology like monoamine systems (Zhukov et al. 2022; Moskaliuk et al. 2023; Pravikova et al. 2024).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Moskaliuk et al. 2023
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Pozzetti, L., & Asquith, C. R. M. (2024) · Archiv der Pharmazie · doi:10.1002/ardp.202400646 · Cited by 6 · see citing works
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Neuropharmacology in the Molecular Epoch
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- Authors
- Moskaliuk, V. S., Kozhemyakina, R. V., Khomenko, T. M., Volcho, K. P., Salakhutdinov, N. F., Kulikov, A. V., Naumenko, V. S., & Kulikova, E. A.
- Affiliations
- Russian Academy of Sciences (RU)
- Novosibirsk Institute of Organic Chemistry (RU)
- Corresponding author
- Kulikova, Elizabeth A.
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-01-04
- Volume
- 24
- Issue
- 2
- Pages
- 983
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9867021
- OpenAlex
- W4313559446
- Cited by
- 11
- References
- 84
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Russian Science Foundation (21-15-00051, FWNR-2022-0010)
- Basic Research Project for a Young Researcher (21-15-00051, FWNR-2022-0010)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- brain-derived neurotrophic factor, serotonin receptors, 5-HT1B receptor, selective breeding, hypothalamus, midbrain, hippocampus, cortex, gene expression
- MeSH terms
- Aggression, Animals, Benzothiepins, Brain, Fear, Hippocampus, Humans, Male, RNA, Messenger, Brain-Derived Neurotrophic Factor, Receptor, Serotonin, 5-HT1B, Rats
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