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The Role of Low-Level Laser Therapy in Bone Healing: Systematic Review
Open accessAbstract
Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process. A better understanding of the cellular mechanisms activated by LLLT can improve its clinical application.
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These effects of low-level lasers seem to occur in the early but not in the later stages of fracture healing.
“These effects seem to occur in the early but not in the later stages of fracture healing (125).”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [125]
Low-level lasers do not produce heat but seem to have effects on pain, inflammation, tissue repair and regeneration by stimulating cellular and enzymatic processes, including those involving stem cells.
“The latter are usually applied at wavelengths of 600 to 1000 nm and do not produce heat but still seem to have effects on pain, inflammation, tissue repair and regeneration by stimulating cellular and enzymatic processes, including those involving stem cells (125).”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [125]
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Cites
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · BMJ · doi:10.1136/bmj.n71 · Cited by 108,283
Bone regeneration: current concepts and future directions
Dimitriou, R. I., Jones, E., McGonagle, D., & Giannoudis, P. V. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-66 · Cited by 2,024
Dickkopf-1 is a master regulator of joint remodeling
Diarra, D., Stolina, M., Polzer, K., Zwerina, J., Ominsky, M. S., Dwyer, D., Korb, A., Smolen, J. S., Hoffmann, M. H., Scheinecker, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1538 · Cited by 1,308
Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.
Avci, P., Gupta, A., Sadasivam, M., Vecchio, D., Pam, Z., Pam, N., & Hamblin, M. R. (2013) · PubMed · Cited by 742
Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration
Yun, Y., Won, J., Jeon, E., Lee, S., Kang, W., Jo, H., Jang, J., Shin, U. S., & Kim, H. (2010) · Journal of Tissue Engineering · doi:10.4061/2010/218142 · Cited by 714
Exact Action Spectra for Cellular Responses Relevant to Phototherapy
Кару, Т. Й., & Kolyakov, S. F. (2005) · Photomedicine and Laser Surgery · doi:10.1089/pho.2005.23.355 · Cited by 617
The roles of signaling pathways in bone repair and regeneration
Majidinia, M., Sadeghpour, A., & Yousefi, B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26042 · Cited by 526
Modulation of the Inflammatory Response for Enhanced Bone Tissue Regeneration
Mountziaris, P. M., & Mikos, A. G. (2008) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2008.0038 · Cited by 499
Irradiation with HeNe laser increases ATP level in cells cultivated in vitro
Кару, Т. Й., Pyatibrat, L. V., & Kalendo, G. S. (1995) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(94)07078-3 · Cited by 433
Role of mesenchymal stem cells in bone regeneration and fracture repair: a review
Wang, X., Wang, Y., Gou, W., Lu, Q., Peng, J., & Lu, S. (2013) · International Orthopaedics · doi:10.1007/s00264-013-2059-2 · Cited by 357
Effects of inflammatory and anti‐inflammatory cytokines on the bone
Schett, G. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02545.x · Cited by 292
Hou, J., Zhang, H., Yuan, X., Li, J., Wei, Y., & Hu, S. (2008) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20709 · Cited by 205
Soleimani, M., Abbasnia, E., Fathi, M., et al. (2011) · Lasers in Medical Science · doi:10.1007/s10103-011-0930-1 · Cited by 165
The role of stem cells in fracture healing and nonunion
Fayaz, H. C., Giannoudis, P. V., Vrahas, M. S., Smith, R. M., Moran, C., Pape, H. C., Krettek, C., & Jupiter, J. B. (2011) · International Orthopaedics · doi:10.1007/s00264-011-1338-z · Cited by 160
Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis
Bai, J., Li, L., Kou, N., Bai, Y., Zhang, Y., Lu, Y., Gao, L., & Wang, F. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02493-5 · Cited by 130
Gavish, L., Perez, L. S., & Gertz, S. D. (2006) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20383 · Cited by 118
Tani, A., Chellini, F., Giannelli, M., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071946 · Cited by 117
Wu, J.-Y., Chen, C., Wang, C., Ho, M., Yeh, M., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054067 · Cited by 97
Low-Level Laser Effect on Proliferation, Migration, and Antiapoptosis of Mesenchymal Stem Cells
Yin, K., Zhu, R., Wang, S., & Zhao, R. C. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0332 · Cited by 92
It is time to test low level laser therapy in Great Britain
Moshkovska, T., & Mayberry, J. F. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.027755 · Cited by 91
Usumez, A., Cengiz, B., Öztuzcu, S., et al. (2013) · Lasers in Medical Science · doi:10.1007/s10103-013-1336-z · Cited by 84
Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications
Caliogna, L., Medetti, M., Bina, V., Brancato, A. M., Castelli, A., Jannelli, E., Ivone, A., Gastaldi, G., Annunziata, S., Mosconi, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147403 · Cited by 82
Self-citationPyo, S.-J., Song, W.-W., Kim, I., et al. (2012) · Lasers in Medical Science · doi:10.1007/s10103-012-1109-0 · Cited by 78
Tim, C. R., Bossini, P. S., Kido, H. W., Malavazi, I., von Zeska Kress, M. R., Carazzolle, M. F., Parizotto, N. A., & Rennó, A. C. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.10.028 · Cited by 76
Li, Y., Xu, Q., Shi, M.-L., et al. (2019) · Microvascular Research · doi:10.1016/j.mvr.2019.103959 · Cited by 74
Hanna, R., Agas, D., Benedicenti, S., Ferrando, S., Laus, F., Cuteri, V., Lacava, G., Sabbieti, M. G., & Amaroli, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00092 · Cited by 73
High-intensity laser application in Orthodontics
Sant’Anna, E. F., Araújo, M. T. D. S., Nojima, L. I., et al. (2017) · Dental Press Journal of Orthodontics · doi:10.1590/2177-6709.22.6.099-109.sar · Cited by 72
AboElsaad, N. S., Soory, M., Gadalla, L. M. A., et al. (2008) · Lasers in Medical Science · doi:10.1007/s10103-008-0576-9 · Cited by 69
Low intensity lasers differently induce primary human osteoblast proliferation and differentiation
de Oliveira, F. A., Matos, A. A., Santesso, M. R., et al. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2016.08.006 · Cited by 66
Fekrazad, R., Ghuchani, M. S., Eslaminejad, M. B., Taghiyar, L., Kalhori, K. A., Pedram, M., Shayan, A. M., Aghdami, N., & Abrahamse, H. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.08.002 · Cited by 63
A Review of Recent Developments in the Molecular Mechanisms of Bone Healing
Rodriguez-Merchan, E. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020767 · Cited by 56
Park, I., Chung, P., & Ahn, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122776 · Cited by 56
Prados‐Frutos, J. C., Rodríguez-Molinero, J., Prados‐Privado, M., et al. (2016) · Lasers in Medical Science · doi:10.1007/s10103-015-1860-0 · Cited by 52
Marques, L., Holgado, L. A., Francischone, L. A., et al. (2014) · Lasers in Medical Science · doi:10.1007/s10103-014-1580-x · Cited by 49
Editorial Comment Biomolecular Mechanisms of Laser Biostimulation
Harris, D. M. (1991) · Journal of Clinical Laser Medicine & Surgery · doi:10.1089/clm.1991.9.277 · Cited by 38
Kunimatsu, R., Gunji, H., Tsuka, Y., Yoshimi, Y., Awada, T., Sumi, K., Nakajima, K., Kimura, A., Hiraki, T., Abe, T., et al. (2018) · Lasers in Medical Science · doi:10.1007/s10103-017-2426-0 · Cited by 36
Nampo, F. K., Cavalheri, V., Ramos, S. D. P., et al. (2015) · Lasers in Medical Science · doi:10.1007/s10103-015-1832-4 · Cited by 33
Manzano‐Moreno, F. J., Medina-Huertas, R., Ramos‐Torrecillas, J., et al. (2015) · Journal of Cranio-Maxillofacial Surgery · doi:10.1016/j.jcms.2015.08.026 · Cited by 29
de Oliveira, G. J. P. L., ARONI, M. A. T., Pinotti, F. E., et al. (2020) · Lasers in Medical Science · doi:10.1007/s10103-019-02943-w · Cited by 28
Rf, Z., Wang, Q., Aa, Z., et al. (2018) · PubMed · doi:10.26355/eurrev_201805_14988 · Cited by 24
Cardoso, M. V., Placa, R. D. V., Sant’Ana, A. C. P., Greghi, S. L. A., Zangrando, M. S. R., de Rezende, M. L. R., de Oliveira, R. C., & Damante, C. A. (2020) · Lasers in Medical Science · doi:10.1007/s10103-020-03056-5 · Cited by 20
Sakata, S., Kunimatsu, R., Tsuka, Y., et al. (2021) · Lasers in Medical Science · doi:10.1007/s10103-021-03371-5 · Cited by 18
Hanna, R., Pawelczyk-Madalińska, M., Sălăgean, T., et al. (2022) · Sensors · doi:10.3390/s22062263 · Cited by 9
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Research works printed but not linked: 1
- Bussadori, 2019, Evaluation of Photobiomodulation Effects on Pain, Edema, Paresthesia, and Bone Regeneration after Surgically Assisted Rapid Maxillary Expansion: Study Protocol for a Randomized, Controlled, and Double Blind Clinical Trial, Medicine, 98, e17756, 10.1097/MD.0000000000017756 · DOI
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Methods to accelerate fracture healing – a narrative review from a clinical perspective
Ganse, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1384783 · Cited by 33
Metadata
- Authors
- Berni, M., Brancato, A. M., Torriani, C., Bina, V., Annunziata, S., Cornella, E., Trucchi, M., Jannelli, E., Mosconi, M., Gastaldi, G., Caliogna, L., Grassi, F. A., & Pasta, G.
- Affiliations
- Policlinico San Matteo Fondazione (IT)
- University of Pavia (IT)
- Corresponding author
- Brancato, Alice Maria
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-04-12
- Volume
- 24
- Issue
- 8
- Pages
- 7094
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC10139216
- OpenAlex
- W4365142097
- Cited by
- 106
- References
- 43
- Citations by year
- 2026: 30 · 2025: 45 · 2024: 24 · 2023: 7
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Trattamenti innovativi per le patologie muscolo scheletriche: dal planning virtuale preoperatorio alla medicina rigenerativa TI-RAMS (RCR-2021-23671217)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
- Health Sciences › Medicine › Complementary and alternative medicine › Biofield Effects and Biophysics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- low-level laser therapy, bone regeneration, fracture healing, angiogenesis, osteogenic differentiation, stem cells, molecular pathways, laser wavelength, energy density, cellular mechanisms
- MeSH terms
- Cell Differentiation, Osteogenesis, Stem Cells, Fracture Healing, Low-Level Light Therapy
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