CoChat
Sign Up
Cited by 160Bone fractures and treatmentsBone Tissue Engineering MaterialsMesenchymal stem cell research

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

The role of stem cells in fracture healing and nonunion

Open access
Fayaz, Hangama C., Giannoudis, Peter V., Vrahas, Mark S., Smith, Raymond Malcolm, Moran, Christopher, Pape, Hans Christoph, Krettek, Christian, Jupiter, Jesse B.·2011·International Orthopaedics
DOI 10.1007/s00264-011-1338-zPMC PMC3193959
Open this paper in CoChat — free account

Abstract

Nonunion and large bone defects present a therapeutic challenge to the surgeon and are often associated with significant morbidity. These defects are expensive to both the health care system and society. However, several surgical procedures have been developed to maximise patient satisfaction and minimise health-care-associated and socioeconomic costs. Integrating recent evidence into the diamond concept leads to one simple conclusion that not only provides us with answers to the "open questions" but also simplifies our entire understanding of bone healing. It has been shown that a combination of neo-osteogenesis and neovascularisation will restore tissue deficits, and that the optimal approach includes a biomaterial scaffold, cell biology techniques, a growth factor and optimisation of the mechanical environment. Further prospective, controlled, randomised clinical studies will determine the effectiveness and economic benefits of treatment with mesenchymal stem cells, not in comparison to other conventional surgical approaches but in direct conjunction with them.

Overview

Integrity signals

Registry

Crossref · 10.1007/s00264-011-1338-z

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 51

  1. Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N, Richardson JB (2007) Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J Bone Joint Surg Br 89(10):1382–1386 · DOI
  2. Bosse MJ, MacKenzie EJ, Kellam JF (2001) A prospective evaluation of the clinical utility of the lower-extremity injury-severity scores. J Bone Joint Surg Am 83-A(1):3–14 · DOI
  3. Brandi ML, Collin-Osdoby P (2005) Vascular biology and the skeleton. J Bone Miner Res 21(2):183–192 · DOI
  4. Chamberlain G, Fox J, Ashton B, Middleton J (2007) Mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25(11):2739–2749 · DOI
  5. Cohnheim J (1867) Arch Path Anat Physiol Klin Med 40:1 · DOI
  6. Connolly JF (1998) Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis. Clin Orthop Relat Res 355:S257–S266 · DOI
  7. Connolly JF, Shindell R (1986) Percutaneous marrow injection for an ununited tibia. The Nebraska Medical Journal 71(4):105–107
  8. Cuomo AV, Virk M, Petrigliano F, Morgan EF, Lieberman JR (2009) Mesenchymal stem cell concentration and bone repair: potential pitfalls from bench to bedside. J Bone Joint Surg Am 91(5):1073–1083 · DOI
  9. Eghbali-Fatourechi GZ, Lamsam J, Fraser D, Nagel D, Riggs BL, Khosla S (2005) Circulating Osteoblast lineage cells in humans. N England J Med 12;352(19):1959–1966 · DOI · Paper page
  10. Eriksen EF, Eghbali-Fatourechi GZ, Khosla S (2007) Remodeling and vascular spaces in bone. J Bone Miner Res 22:1–6 · DOI
  11. Fayaz HC, Yaremchuk M, Jupiter J (2010) Reconstruction of a traumatic transmetatarsal amputation with use of a latissimus dorsi free tissue transfer and the Ilizarov technique: a case report. J Bone Joint Surg Am 92(2):459–464 · DOI
  12. Funk JF, Matziolis G, Krocker D, Perka C (2007) Promotion of bone healing through clinical application of autologous periosteum derived stem cells in a case of atrophic non-union. Z Orthop Unfall 145(6):790–794 · DOI
  13. Garg NK, Gaur S, Sharma S (1993) Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture. Acta Orthopaedica Scandinavica 64(6):671–672 · DOI
  14. Giannoudis PV, Tzioupis C, Green J (2009) Surgical techniques: how I do it? The Reamer/Irrigator/Aspirator (RIA) system. Injury 40(11):1231–1236 · DOI
  15. Giannoudis PV, Einhorn TA, Marsh D (2007) Injury, Int J Care Injured 38S4:S3–S6 · DOI
  16. Giotakis N, Narayan B, Nayagam S (2007) Distraction osteogenesis and nonunion of the docking site: is there an ideal treatment option? Injury 38:S100e7 · DOI
  17. Goel A, Sangwan SS, Siwach RC, Ali AM (2005) Percutaneous bone marrow grafting for the treatment of tibial non-union. Injury 36(1):203–206 · DOI
  18. Gugala Z, Gogolewski S (1999) Regeneration of segmental diaphyseal defects in sheep tibiae using resorbable polymeric membranes: a preliminary study. J Orthop Trauma 13:187–195 · DOI
  19. Hauge EM, Qvesel D, Eriksen EF, Mosekilde L, Melsen F (2001) Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers. J Bone Miner Res 16:1575–1582 · DOI · Paper page
  20. Healey JH, Zimmerman PA, McDonnell JM, Lane JM (1990) Percutaneous bone marrow grafting of delayed union and nonunion in cancer patients. Clin Orthop Relat Res 256:280–285 · DOI
  21. Hernigou PH, Poignard A, Beaujean F, Rouard H (2005) Percutaneous autologous bone-marrow grafting for nonunions: influence of the number and concentration of progenitor cells, Journal of Bone and Joint Surgery A 87(7):1430–1437 · DOI
  22. Honczarenko M, Le Y, Swierkowski M et al (2006) Human bone morrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells 24(4):1030–1041 · DOI · Paper page
  23. Horwitz EM, Prockop DJ, Fitzpatrick LA et al (1995) Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 5:309–313 · DOI
  24. Ivkovic A, Marijanovic I, Hudetz D, Porter RM, Pecina M, Evans CH (2011) Regenerative medicine and tissue engineering in orthopaedic surgery. Front Biosci (Elite ed)1;3:923–944 · DOI
  25. Iwakura T, Miwa M, Sakai Y, Niikura T, Lee SY, Oe K, Hasegawa T, Kuroda R, Fujioka H, Doita M, Kurosaka M (2009) Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro. J Orthop Res 27(2):208–215 · DOI
  26. Keating JF, Simpson AH, Robinson CM (2005) The management of fractures with bone loss. J Bone Joint Surg Br 87:142–150 · DOI
  27. Kitoh H, Kawasumi M, Kaneko H, Ishiguro N (2009) Differential Effects of Culture-expanded Bone Marrow Cells on the Regeneration of Bone Between the Femoral and the Tibial Lengthenings. J Pediatr Orthop 29:643–649 · DOI
  28. Lin CH, Wei FC, Chen HC, Chuang DC (1999) Outcome comparison in traumatic lower-extremity reconstruction by using various composite vascularized bone transplantation. Plast Reconstr Surg 104:984–992 · DOI
  29. Lindsey RW, Gugala Z, Milne E, Sun M, Gannon FH, Latta LL (2006) The efficacy of cylindrical titanium mesh cage for the reconstruction of a critical-size canine segmental femoral diaphyseal defect. J Orthop Res 24(7):1438–1453 · DOI
  30. Liu ZJ, Zhuge Y, Velazquez OC (2009) Trafficking and differentiation of mesenchymal stem cells. JCell Bochem 106(6):984–991 · DOI
  31. Maes C, Kobayashi T, Selig MK et al (2010) Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell 19:329–344 · DOI · Paper page
  32. Marcacci M, Kon E, Moukhachev V, Lavroukov A, Kutepov S, Quarto R, Mastrogiacomo M, Cancedda R (2007) Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng 13(5):947–955 · DOI · Paper page
  33. Masquelet AC, Fitoussi F, Begue T, Muller GP (2000) Reconstruction of the long bones by the induced membrane and spongy autograft [in French]. Ann Chir Plast Esthet 45:346–353
  34. Masquelet AC (2003) Muscle reconstruction in reconstructive surgery: soft tissue repair and long bone reconstruction. Langenbecks Arch Surg 388:344–346 · DOI
  35. Megas P (2005) Classification of non-union. Injury 36(SuppI4):S30–S37
  36. Miller MA, Ivkovic A, Porter R, Harris MB, Estok DM, Smith RM, Evans CH, Vrahas MS (2011) Autologous bone grafting on steroids: preliminary clinical results. A novel treatment for nonunions and segmental bone defects. Int Orthop Apr 35(4):599–605 · DOI
  37. Mödder UI, Khosla S (2008) Skeletal stem/osteoprogenitor cells: current concepts, alternate hypotheses, and relationship to the bone remodeling compartment. J Cell Biochem 1 103(2):393–400 · DOI
  38. Novicoff WM, Manaswi A, Hogan MV, Brubaker SM, Mihalko WM, Saleh KJ (2008) Critical analysis of the evidence for current technologies in bone-healing and repair. Journal of Bone and Joint Surgery A 90(1):85–91 · DOI
  39. Pecina M, Vukicevic S (2007) Biological aspects of bone, cartilage and tendon regeneration. Int Orthop 31(6):719–720 · DOI
  40. Pelissier P, Masquelet AC, Bareille R, Pelissier SM, Amedee J (2004) Induced membranes secrete growth factors including vascular and osteoinductive factors and could stimulate bone regeneration. J Orthop Res 22(1):73–79 · DOI
  41. Pountos I, Giannoudis PV (2005) Biology of mesenchymal stem cells. Injury 36(Suppl 3):S8–S12 · DOI
  42. Ripamonti U (1992) Calvarial reconstruction in baboons with porous hydroxyapatite. J Craniofac Surg 3(3):149–159 · DOI
  43. Ripamonti U (1993) Delivery systems for bone morphogenetic proteins. A summary of experimental studies in primate models. Ann Chir Gynaecol Suppl 207:13–24
  44. Russell AT, Taylor CJ, Lavelle DG (1991) Fractures of tibia and fibula. In: Bucholz RW, Heckman JD, Court-Brown CM (eds) Fractures in Adults, Rockwood and Green, vol 3. pp 1915–1982
  45. Sambrook PN, Chen CJS, March LM et al (2006) High bone turnover is an independent predictor of mortality in the frail elderly. J Bone Miner Res 21:549–555 · DOI
  46. Schmitz JP, Hollinger JO (1986) The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop Rel Res 205:299–308 · DOI
  47. Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, Kon E, Marcacci M (2001) Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 1; 344(5):385–386 · DOI
  48. Taylor CJ (1992) Delayed union and nonunion of fractures. In: Crenshaw AH (ed) Campbell’s Operative Orthopaedics, vol 28. Mosby, pp 1287—1345
  49. Towler DA (2008) The osteogenic-angiogenic interface: novel insights into the biology of bone formation and fracture repair. Curr Osteoporos Rep 6(2):67–71 · DOI
  50. Vacanti CA, Bonassar LJ, Vacanti MP, Shufflebarger (2001) Replacement of an avulsed phalanx with tissue engineered bone. N England J Med 344(20) · DOI
  51. Yefang Z, Hutmacher DW, Varawan SL, Meng LT (2007) Comparison of human alveolar osteoblasts cultured on polymer-ceramic composite scaffolds and tissue culture plates. Int J Oral Maxillofac Surg 36:137–145 · DOI

Cited by

Sorted by citations

Metadata

Authors
Fayaz, H. C., Giannoudis, P. V., Vrahas, M. S., Smith, R. M., Moran, C., Pape, H. C., Krettek, C., & Jupiter, J. B.
Affiliations
  • Harvard University (US)
  • University of Leeds (GB)
  • Queen's Medical Centre (GB)
  • Universitätsklinikum Aachen (DE)
  • Medizinische Hochschule Hannover (DE)
Corresponding author
Giannoudis, Peter V.
ORCID
Venue
International Orthopaedics
Publisher
Springer Science and Business Media LLC
Published
2011-08-24
Volume
35
Issue
11
Pages
1587-1597
ISSN
  • 0341-2695 (ISSN-L)
  • 1432-5195
DOI
10.1007/s00264-011-1338-z
PMC
PMC3193959
OpenAlex
W2109937981
Cited by
160
References
2
Citations by year
2026: 2 · 2025: 11 · 2024: 5 · 2023: 16 · 2022: 8 · 2021: 15 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 17 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 5
FWCI
1.01
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • International Orthopaedics (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone fractures and treatments
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
stem cells, fracture healing, nonunion, bone defects, mesenchymal stem cells, neovascularization, biomaterial scaffolds, growth factors, mechanical environment, bone regeneration, economic costs
MeSH terms
Bone Marrow Cells, Bone Regeneration, Fractures, Ununited, Humans, Osteogenesis, Fracture Healing, Cell Transplantation, Neovascularization, Physiologic, Tissue Engineering, Tissue Scaffolds, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review