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Cited by 14Osteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchPeriodontal Regeneration and Treatments

Effects of a Combination of Polynucleotide and Hyaluronic Acid for Treating Osteoarthritis

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Choi, Seung Hee, Kim, Hyun Chul, Jang, Seul Gi, Lee, Yeon Jae, Heo, Jun Young, Kweon, Gi Ryang, Ryu, Min Jeong·2024·International Journal of Molecular Sciences
DOI 10.3390/ijms25031714PMC PMC10855695
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Abstract

Knee osteoarthritis (OA), an age-related degenerative disease characterized by severe pain and disability, is treated using polynucleotides (PNs) and hyaluronic acid (HA). The intra-articular (IA) injection of HA has been studied extensively in both animal models and in humans; however, the efficacy and mechanisms of action remain unclear. In addition, there has been a paucity of research regarding the use of PN alone or in combination with HA in OA. To investigate the effect of the combined injection of PN and HA in vivo, pathological and behavioral changes were assessed in an OA model. Anterior cruciate ligament transection and medial meniscectomy were performed in Sprague-Dawley rats to create the OA animal model. The locomotor activity improved following PNHA injection, while the OARSI grade improved in the medial tibia and femur. In mild OA, TNFα levels decreased histologically in the PN, HA, and PNHA groups but only the PNHA group showed behavioral improvement in terms of distance. In conclusion, PNHA exhibited anti-inflammatory effects during OA progression and improved locomotor activity regardless of the OARSI grade.

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  • PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes.

    “PNs are often combined with other biocompatible polymers, such as HA, poly-L-lactic acid, or various bioactive compounds, to achieve synergistic effects on skin texture and rejuvenation outcomes [21,24,31,32,33,34,35,40,41,42,150].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [34]

    The Materials and Methods section confirms that the authors mixed PN with HA, but the study concerns osteoarthritis, not skin texture or rejuvenation. The Discussion states that the combination did not show a synergistic or additive effect on behavioral outcomes in the animal OA model. The paper does not substantiate the claim about poly-L-lactic acid or other bioactive compounds. (LLM, conf=0.88)

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Authors
Choi, S. H., Kim, H. C., Jang, S. G., Lee, Y. J., Heo, J. Y., Kweon, G. R., & Ryu, M. J.
Affiliations
  • Joonghun Pharmaceutical Co., Ltd., 15 Gukhoe-daero 62-gil, Yeongdeungpo-gu, Seoul 07236, Republic of Korea
  • Chungnam National University (KR)
Corresponding author
Ryu, Min Jeong
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2024-01-30
Volume
25
Issue
3
Pages
1714
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms25031714
PMC
PMC10855695
OpenAlex
W4391362583
Cited by
14
References
66
Citations by year
2026: 3 · 2025: 7 · 2024: 4
FWCI
4.51
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (cc-by)
Funders
Ministry of SMEs and Startups (MSS, Republic of Korea) (S3034590)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
knee osteoarthritis, polynucleotides, hyaluronic acid, combination therapy, intra-articular injection, anterior cruciate ligament transection, medial meniscectomy, rat osteoarthritis model, locomotor activity, anti-inflammatory activity, TNF-α
MeSH terms
Animals, Humans, Hyaluronic Acid, Injections, Intra-Articular, Polynucleotides, Anterior Cruciate Ligament, Rats, Sprague-Dawley, Osteoarthritis, Knee, Rats

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