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Cited by 50Plant Stress Responses and TolerancePlant Molecular Biology ResearchEpigenetics and DNA Methylation

Epigenetic Modifications of Hormonal Signaling Pathways in Plant Drought Response and Tolerance for Sustainable Food Security

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Kaya, Cengiz, Uğurlar, Ferhat, Adamakis, Ioannis-Dimosthenis S.·2024·International Journal of Molecular Sciences
DOI 10.3390/ijms25158229PMC PMC11311266
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Abstract

Drought significantly challenges global food security, necessitating a comprehensive understanding of plant molecular responses for effective mitigation strategies. Epigenetic modifications, such as DNA methylation and histone modifications, are key in regulating genes and hormones essential for drought response. While microRNAs (miRNAs) primarily regulate gene expression post-transcriptionally, they can also interact with epigenetic pathways as potential effectors that influence chromatin remodeling. Although the role of miRNAs in epigenetic memory is still being explored, understanding their contribution to drought response requires examining these indirect effects on epigenetic modifications. A key aspect of this exploration is epigenetic memory in drought-adapted plants, offering insights into the transgenerational inheritance of adaptive traits. Understanding the mechanisms that govern the maintenance and erasure of these epigenetic imprints provides nuanced insights into how plants balance stability and flexibility in their epigenomes. A major focus is on the dynamic interaction between hormonal pathways—such as those for abscisic acid (ABA), ethylene, jasmonates, and salicylic acid (SA)—and epigenetic mechanisms. This interplay is crucial for fine-tuning gene expression during drought stress, leading to physiological and morphological adaptations that enhance plant drought resilience. This review also highlights the transformative potential of advanced technologies, such as bisulfite sequencing and CRISPR-Cas9, in providing comprehensive insights into plant responses to water deficit conditions. These technologies pave the way for developing drought-tolerant crops, which is vital for sustainable agriculture.

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  • Hormonal imbalances caused by frequent use of high concentrations of auxins and cytokinins can destabilize the plant's hormonal equilibrium and trigger genetic instability.

    “Likewise, hormonal imbalances caused by the frequent use of high concentrations of auxins and cytokinins, though vital for shoot initiation and proliferation, can destabilize the plant's hormonal equilibrium and trigger genetic instability [73,74].”

    From Somaclonal Variation and Clonal Fidelity in Commercial Micropropagation: Challenges and Perspectives (2025) · cites this paper as [74]

    Section 3 (page not provided) discusses epigenetic regulation of hormone signaling under drought stress, including auxin and cytokinin-related pathways. It does not address frequent use of high-concentration auxins and cytokinins for shoot proliferation or link that use to hormonal imbalance or genetic instability. Searches for those terms and for tissue-culture variation found no supporting passage. (LLM, conf=0.74)

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Authors
Kaya, C., Uğurlar, F., & Adamakis, I.-D. S.
Affiliations
  • Harran University (TR)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
Adamakis, Ioannis-Dimosthenis S.
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2024-07-28
Volume
25
Issue
15
Pages
8229
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms25158229
PMC
PMC11311266
OpenAlex
W4401118095
Cited by
50
References
109
Citations by year
2026: 23 · 2025: 26 · 2024: 1
FWCI
1.90
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Harran Üniversitesi
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
plant responses to drought, drought tolerance, epigenetic modifications, DNA methylation, histone modifications, microRNA, epigenetic memory, transgenerational inheritance, abscisic acid, ethylene, jasmonates, salicylic acid, hormonal signaling pathways, chromatin remodeling, bisulfite sequencing, CRISPR/Cas9, drought-resistant crops, food security
MeSH terms
Food Security, Adaptation, Physiological, Plant Growth Regulators, Plants, Stress, Physiological, Signal Transduction, Gene Expression Regulation, Plant, DNA Methylation, MicroRNAs, Epigenesis, Genetic, Droughts

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