Targeting Neutrophil Function as Therapy for Hidradenitis Suppurativa
Open accessAbstract
Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterized by painful nodules, abscesses, and epithelialized tunnels, predominantly affecting flexural regions. With a global prevalence of approximately 1%, HS has a significant negative impact on quality of life. Multi-omics and histopathology studies have revealed a complex interplay between innate and adaptive immunity in HS, with neutrophils emerging as important drivers of inflammation. While therapies targeting TNF-α and IL-17 isoforms offer a degree of benefit, significant unmet need remains. Neutrophil signatures in HS lesions and the circulation underscore the rationale for selective modulation of neutrophil function. Strategies advancing through clinical trials include inhibition of chemokine-mediated trafficking, neutrophil serine protease inactivation and suppression of neutrophil extracellular traps (NETs), which amplify inflammatory and autoimmune responses. These emerging therapies mark a significant shift toward targeted neutrophil modulation, offering new opportunities to improve outcomes for patients with HS.
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In advanced hidradenitis suppurativa with tunnel formation and fibrosis, surgical management remains essential, often combined with medical therapy to control inflammation and prevent recurrence.
“In advanced diseases with tunnel formation and fibrosis, surgical management remains essential, often combined with medical therapy to control inflammation and prevent recurrence [40,44,45,46,47].”
From The Cutaneous Immune Microenvironment in Selected Inflammatory Skin Diseases: Linking Histopathology, Mechanisms, and Targeted Therapy (2026) · cites this paper as [45]
The Introduction says moderate-to-severe HS can progress to skin tunnels associated with a more aggressive course. Section 1.6 notes past reliance on surgery and antibiotics, but does not say surgery remains essential for tunnels or fibrosis, or that combining it with medical therapy prevents recurrence. (LLM, conf=0.84)
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Sorted by citations
Tinca, A. C., Cozac-Szoke, A. R., & Cotoi, O. S. (2026) · Dermatopathology · doi:10.3390/dermatopathology13020022 · Cited by 1 · see citing works
- Authors
- Meldrum, E., & Ingram, J. R.
- Affiliations
- BOS (Germany) (DE)
- Cardiff University (GB)
- Corresponding author
- Meldrum, Eric
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2026-02-23
- Volume
- 27
- Issue
- 4
- Pages
- 2076
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC12940336
- OpenAlex
- W7131115539
- Cited by
- 3
- References
- 65
- Citations by year
- 2026: 3
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Hidradenitis Suppurativa and Treatments
- Health Sciences › Medicine › Epidemiology › Autoimmune and Inflammatory Disorders
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- hidradenitis suppurativa, neutrophils, neutrophil serine proteases, neutrophil extracellular traps, innate and adaptive immunity, inflammation, TNF-alpha inhibitors, IL-17 inhibitors, targeted therapy
- MeSH terms
- Host-Directed Therapy, Animals, Humans, Neutrophils, Hidradenitis Suppurativa, Extracellular Traps
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