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CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics
Open accessAbstract
Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.
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Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Cited by
Keefe, A. D., Pai, S., & Ellington, A. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3141 · Cited by 2,289
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,730
Aptamer to ErbB-2/HER2 enhances degradation of the target and inhibits tumorigenic growth
Mahlknecht, G., Maron, R., Mancini, M., Schechter, B., Sela, M., & Yarden, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302594110 · Cited by 169
Metadata
- Authors
- Guo, K.-T., Ziemer, G., Paul, A., & Wendel, H. P.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2008-04-24
- Volume
- 9
- Issue
- 4
- Pages
- 668-678
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W1963659626
- Cited by
- 169
- References
- 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guo, K.-T., Ziemer, G., Paul, A., & Wendel, H. P. (2008). CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms9040668
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.