Abuse of Licit and Illicit Psychoactive Substances in the Workplace: Medical, Toxicological, and Forensic Aspects
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About one-third of adult life is spent in the workplace. The use of psychoactive substances is a major preventable cause of morbidity and mortality. The consumption of psychoactive substances during or outside working hours greatly increases the frequency and severity of labor accidents, as well as the workers’ poor general state of health and productivity, implying higher costs for enterprises. It is the responsibility of organizations to ensure the safety and health of their workers. These cannot be limited to traditional routine clinical exams, as other aspects also have an impact on health. Thus, prevention and intervention in the consumption of psychoactive substances (e.g., ethanol, opioids, central nervous system stimulants or depressants, hallucinogens, Cannabis derivatives, dissociative substances, and inhalants) in labor activity should be considered as an investment of organizations and not as a cost, in view of the professional, personal, and family advantages for workers and employers, with a potential impact on productivity, security, health, and quality of life at work. Despite the extensive literature on the subject, each article generally focuses on one or another aspect of a very specific nature, not tackling the problem in a holistic way by confronting clinical, safety, and legal issues. This article presents a reflection on the legal, laboratorial, clinical, ethical, forensic, and safety concerns related to the consumption of psychoactive substances in the workplace, and can be a cross-cutting contribution to occupational medicine, forensic medicine, and insurance medicine, as well as for entrepreneurs, lawyers, judges, workers, and technicians from the public and private sectors that develop projects in this area. This discussion is based on general principles established internationally and highlights the role of the occupational healthcare system and other decision-making actors in the prevention and supervision of workplace psychoactive consumption.
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The use of psychoactive substances can impair judgment, reduce productivity, compromise job performance, and increase the risk of workplace injuries.
“The use of psychoactive substances can impair judgment, reduce productivity, compromise overall job performance, and significantly increase the risk of workplace injuries [13].”
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Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance
Dinis-Oliveira, R. J. (2017) · Drug Metabolism Reviews · doi:10.1080/03602532.2016.1278228 · Cited by 224 · cited 1× · see citing works
“Hallucinogens, such as the diethylamide of lysergic acid (LSD), mescaline, psilocybin, and psilocin, also have a pronounced effect on workplace performance [52,53].”
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Bebangnidong, J., Norvivor, F. A., Umar, A., Bautsi, D. A., & Gmayinaam, V. U. (2026) · BMC Public Health · doi:10.1186/s12889-026-26972-7
“The use of psychoactive substances can impair judgment, reduce productivity, compromise overall job performance, and significantly increase the risk of workplace injuries [13].”
- Authors
- Dinis-Oliveira, R. J., & Magalhães, T.
- Affiliations
- IINFACTS—Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal
- Universidade do Porto (PT)
- Corresponding author
- Magalhães, Teresa
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2020-03-12
- Volume
- 9
- Issue
- 3
- Pages
- 770
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC7141377
- OpenAlex
- W3011723004
- Cited by
- 23
- References
- 2
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 7 · 2023: 4 · 2021: 2 · 2020: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Health Sciences › Health Professions › Occupational Therapy › Occupational Health and Safety in Workplaces
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- drug use, workplace drug use, occupational health, occupational safety, labor accidents, substance use prevention, forensic toxicology, insurance medicine, occupational health services, cannabis, opioids, inhalants, workplace drug testing, labor law
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