The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in Pathogenic Fusarium
Open accessPublished version of a preprint
Abstract
Fusarium species are among the filamentous fungi with the most pronounced impact on agricultural production and human health. The mycotoxins produced by pathogenic Fusarium not only attack various plants including crops, causing various plant diseases that lead to reduced yields and even death, but also penetrate into the food chain of humans and animals to cause food poisoning and consequent health hazards. Although sporadic studies have revealed some of the biosynthetic pathways of Fusarium toxins, they are insufficient to satisfy the need for a comprehensive understanding of Fusarium toxin production. In this study, we focused on 35 serious pathogenic Fusarium species with available genomes and systematically analyzed the ubiquity of the distribution of identified Fusarium- and non-Fusarium-derived fungal toxin biosynthesis gene clusters (BGCs) in these species through the mining of core genes and the comparative analysis of corresponding BGCs. Additionally, novel sesterterpene synthases and PKS_NRPS clusters were discovered and analyzed. This work is the first to systematically analyze the distribution of related mycotoxin biosynthesis in pathogenic Fusarium species. These findings enhance the knowledge of mycotoxin production and provide a theoretical grounding for the prevention of fungal toxin production using biotechnological approaches.
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Metadata
- Authors
- Lin, C., Feng, X.-L., Liu, Y., Li, Z.-C., Li, X.-Z., & Qi, J.
- Affiliations
- Northwest A&F University (CN)
- Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Xianyang 712100, China
- State Key Laboratory of Plateau Ecology and Agriculture, Qinghai Academy of Animal and Veterinary Sciences, Qinghai University, Xining 810016, China
- Corresponding author
- Qi, Jianzhao
- Venue
- Journal of Fungi
- Publisher
- MDPI AG
- Published
- 2023-08-15
- Volume
- 9
- Issue
- 8
- Pages
- 850
- ISSN
- 2309-608X (ISSN-L)
- PMC
- PMC10455296
- OpenAlex
- W4385840277
- Cited by
- 32
- References
- 110
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 6 · 2023: 2
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Fungi (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Key R&D Projects in Shaanxi Province of China (2023-YBSF-164)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogens and Fungal Diseases
- Keywords
- Fusarium, mycotoxin biosynthesis, biosynthetic gene clusters, secondary metabolites, fungal toxin production, comparative genomics, plant pathogens, food poisoning
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- CoChat. (2026). Citation check: Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in Pathogenic Fusarium. https://app.cochat.ai/papers/10.3390/jof9080850
- The paper
- Lin, C., Feng, X.-L., Liu, Y., Li, Z.-C., Li, X.-Z., & Qi, J. (2023). Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in Pathogenic Fusarium. Journal of Fungi. https://doi.org/10.3390/jof9080850
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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