Cited by 131Pharmacogenetics and Drug MetabolismGenomics and Rare DiseasesGenetics, Bioinformatics, and Biomedical Research

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Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey

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Owusu Obeng, Aniwaa, Fei, Kezhen, Levy, Kenneth D., Elsey, Amanda R., Pollin, Toni I., Ramirez, Andrea H., Weitzel, Kristin W., Horowitz, Carol R.·2018·Journal of Personalized Medicine

DOI 10.3390/jpm8030024PMC PMC6163471

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Abstract

Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.

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Authors: Owusu Obeng, A., Fei, K., Levy, K. D., Elsey, A. R., Pollin, T. I., Ramirez, A. H., Weitzel, K. W., & Horowitz, C. R.
Affiliations: The Charles Bronfman Institute for Personalized Medicine and Department of Genetics and Genomic Sciences, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Icahn School of Medicine at Mount Sinai (US)
Indiana University Indianapolis (US)
University of Florida Health (US)
University of Maryland, Baltimore (US)
Vanderbilt University (US)
ORCID: Fei, Kezhen
Levy, Kenneth D.
Pollin, Toni I.
Ramirez, Andrea H.
Horowitz, Carol R.
Venue: Journal of Personalized Medicine
Publisher: MDPI AG
Published: 2018-07-24
Volume: 8
Issue: 3
Pages: 24
ISSN: 2075-4426 (ISSN-L)
DOI: 10.3390/jpm8030024
PMC: PMC6163471
OpenAlex: W2884510764
Cited by: 131
References: 51
Citations by year: 2026: 2 · 2025: 11 · 2024: 21 · 2023: 12 · 2022: 14 · 2021: 28 · 2020: 28 · 2019: 14 · 2018: 1
FWCI: 19.53
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Personalized Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
IUScholarWorks (Indiana University) (submittedVersion, cc-by-nc-nd)
Purdue University Indianapolis (Indiana University) (submittedVersion, cc-by-nc-nd)
Funders: NIH/NHGRI (5U01HG007278; U01HG006380; 5U01HG007762; U01HG007775; U01HG007269; U01HG07253)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genetics, Bioinformatics, and Biomedical Research
Keywords: genomic medicine, clinical implementation, physician attitudes, implementation barriers, genetic testing, pharmacogenetics, disease genetics, physician preparedness, personalized medicine

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Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey

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