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Cited by 14Traumatic Brain Injury and Neurovascular DisturbancesNeurological Disease Mechanisms and TreatmentsCerebrovascular and genetic disorders

Age-Related Alterations of Cerebral Autoregulation

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Ungvari, Anna, Kállai, Attila, Stankovics, Levente, Lendvai-Emmert, Dominika, Gulej, Rafal, Pal, Eva, Patai, Roland, Csik, Boglarka +6 more·2025·Life
DOI 10.3390/life15111669PMC PMC12653112
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Abstract

Intact regulation of cerebral blood flow (CBF) is essential for preserving cognitive function and reducing the risk of cerebrovascular events, particularly in the aging population. Autoregulation of CBF is one of the fundamental mechanisms that ensure constant supply for brain tissue by maintaining relatively stable perfusion despite fluctuations in systemic blood pressure. It also acts as a critical protective mechanism, shielding the fragile cerebral microcirculation from potentially harmful pressure fluctuations and hence excessive pulsatility. The loss or attenuation of this protective mechanism with aging or disease increases the vulnerability of the microvasculature to structural damage, blood–brain barrier (BBB) disruption, and the development of cerebral small vessel disease. This mini-review summarizes current understanding of how aging affects cerebral autoregulation, highlighting underlying mechanisms, clinical consequences, and potential strategies to preserve cerebrovascular health in older adults.

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  • In the cerebral circulation, CHIP-associated processes manifest as increased risk of ischemic stroke, white matter hyperintensities, lacunar infarcts, and microvascular injury, which are hallmarks of cerebral small vessel disease strongly associated with cognitive decline and executive dysfunction.

    “In the cerebral circulation, these processes manifest as increased risk of ischemic stroke, white matter hyperintensities, lacunar infarcts, and microvascular injury, which are hallmarks of cerebral small vessel disease strongly associated with cognitive decline and executive dysfunction [16,17].”

    From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [17]

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Authors
Ungvari, A., Kállai, A., Stankovics, L., Lendvai-Emmert, D., Gulej, R., Pal, E., Patai, R., Csik, B., Fekete, M., Lipecz, Á., Csípő, T., Benyó, Z., Csiszar, A., & Toth, P.
Affiliations
  • Semmelweis University (HU)
  • University of Pecs (HU)
  • Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104-3609, USA
  • Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary
  • University of Oklahoma Health Sciences Center (US)
  • Institute of Preventive Medicine and Public Health, Semmelweis University, 1089 Budapest, Hungary
Corresponding author
Toth, Peter
ORCID
Venue
Life
Publisher
MDPI AG
Published
2025-10-27
Volume
15
Issue
11
Pages
1669
ISSN
2075-1729 (ISSN-L)
DOI
10.3390/life15111669
PMC
PMC12653112
OpenAlex
W4415569086
Cited by
14
References
165
Citations by year
2026: 14
FWCI
2.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Life (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • American Heart Association (AHA CDA941290)
  • Oklahoma Center for the Advancement of Science and Technology, the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295, R01AG070915, K01AG073614, K01AG073613, R03AG070479)
  • National Institute of Neurological Disorders and Stroke (R01NS100782)
  • National Cancer Institute (R01CA255840)
  • Presbyterian Health Foundation, the Oklahoma Nathan Shock Center (P30AG050911)
  • Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund (TKP2021-NKTA-47)
  • National Cardiovascular Laboratory Program (RRF-2.3.1-21-2022-00003)
  • National Research, Development and Innovation Fund of Hungary (135784)
  • National Research, Development and Innovation Office (OTKA K-134555, OTKA FK-146334)
  • National Clinical Neuroscience Laboratory (RRF-2.3.1-21-2022-00011)
  • Thematic Excellence Program 2021 Health sub-program of the Ministry for Innovation and Technology in Hungary (EGA-16)
  • National Research, Development and Innovation Fund (ADVANCED_24)
  • National Research, Development, and Innovation Fund (EKÖP-2024-9)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
Keywords
cerebral autoregulation, cerebral blood flow, aging, cerebrovascular health, cerebral small vessel disease, blood-brain barrier, cerebral microcirculation, pulsatility, systemic blood pressure, older adults

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