CoChat
Sign Up
Cited by 126Advanced Drug Delivery SystemsNanocomposite Films for Food PackagingHydrogels: synthesis, properties, applications

Design of chitosan and its water soluble derivatives-based drug carriers with polyelectrolyte complexes

Open access
Wu, Qing-Xi, Lin, Dong-Qiang, Yao, Shan-Jing·2014·Marine Drugs
DOI 10.3390/md12126236PMC PMC4278227
Open this paper in CoChat — free accountOpen PDF

Abstract

Chitosan, the cationic polysaccharide derived from the natural polysaccharide chitin, has been studied as a biomaterial for more than two decades. As a polycationic polymer with favorable properties, it has been widely used to form polyelectrolyte complexes with polyanions for various applications in drug delivery fields. In recent years, a growing number of studies have been focused on the preparation of polyelectrolyte complexes based on chitosan and its water soluble derivatives. They have been considered well-suited as biomaterials for a number of vital drug carriers with targeted/controlled release profiles, e.g., films, capsules, microcapsules. In this work, an overview highlights not only the favorable properties of chitosan and its water soluble derivatives but also the good performance of the polyelectrolyte complexes produced based on chitosan. Their various types of applications as drug carriers are reviewed in detail.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/md12126236

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Chitosan is poorly soluble in water under physiological conditions, which limits its widespread use in tissue engineering.

    “However, chitosan is poorly soluble in water under physiological conditions, which limits its widespread use in TE [44].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [44]

    Section 2.2 (Solubility; page unavailable) states that chitosan is insoluble at neutral pH and usually requires acidic solvents to prepare a solution. The paper does not say that this limits its widespread use in tissue engineering; its Introduction instead describes potential bioengineering applications. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

No references could be resolved yet.

Research works printed but not linked: 86

  1. [1]Onishi H. Machida Y. Biodegradation and distribution of water-soluble chitosan in mice Biomaterials 1999 20 175 182 10.1016/S0142-9612(98)00159-8 10022787 · DOI
  2. [2]Xia W.S. Liu P. Liu J. Advance in chitosan hydrolysis by non-specific cellulases Bioresour. Technol. 2008 99 6751 6762 10.1016/j.biortech.2008.01.011 18328693 · DOI
  3. [3]Zhang H. Alsarra I.A. Neau S.H. An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon Int. J. Pharm. 2002 239 197 205 10.1016/S0378-5173(02)00112-6 12052705 · DOI
  4. [4]Zhang Y.Q. Niu Y.G. Luo Y.C. Ge M. Yang T. Yu L.L. Wang Q. Fabrication, characterization and antimicrobial activities of thymol-loaded zein nanoparticles stabilized by sodium caseinate-chitosan hydrochloride double layers Food Chem. 2014 142 269 275 10.1016/j.foodchem.2013.07.058 24001841 · DOI
  5. [5]Dang Q.F. Yan J.Q. Li Y. Cheng X.J. Liu C.S. Chen X.G. Chitosan acetate as an active coating material and its effects on the storing of Prunus avium L. J. Food Sci. 2010 75 S125 S131 10.1111/j.1750-3841.2009.01483.x 20492258 · DOI
  6. [6]Parodi B. Russo E. Caviglioli G. Baldassari S. Gaglianone N. Schito A.M. Cafaggi S. A chitosan lactate/poloxamer 407-based matrix containing Eudragit RS microparticles for vaginal delivery of econazole: Design and in vitro evaluation Drug Dev. Ind. Pharm. 2013 39 1911 1920 10.3109/03639045.2012.694589 22681543 · DOI
  7. [7]Xu P.S. Bajaj G. Shugg T. van Alstine W.G. Yeo Y. Zwitterionic chitosan derivatives for pH-sensitive stealth coating Biomacromolecules 2010 11 2352 2358 10.1021/bm100481r 20695636 PMC2941802 · DOI
  8. [8]Bajaj G. van Alstine W.G. Yeo Y. Zwitterionic chitosan derivative, a new biocompatible pharmaceutical excipient, prevents endotoxin-mediated cytokine release PLoS One 2012 7 1 10 PMC3265529 22292072
  9. [9]Shu S.J. Zhang X.G. Teng D.Y. Wang Z. Li C.X. Polyelectrolyte nanoparticles based on water-soluble chitosan-poly(l-aspartic acid)-polyethylene glycol for controlled protein release Carbohyd. Res. 2009 344 1197 1204 10.1016/j.carres.2009.04.018 19508912 · DOI
  10. [10]Čalija B. Cekić N. Savić S. Daniels R. Marković B. Milić J. pH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit® L100–55 “sandwich” polyelectrolyte complex Colloid. Surf. B 2013 110 395 402 10.1016/j.colsurfb.2013.05.016 23751419 · DOI
  11. [11]Franco R.A. Nguyen T.H. Lee B.T. Preparation and characterization of electrospun PCL/PLGA membranes and chitosan/gelatin hydrogels for skin bioengineering applications J. Mater. Sci. Mater. M. 2011 22 2207 2218 10.1007/s10856-011-4402-8 21805330 · DOI
  12. [12]Mahmoudzadeh M. Fassihi A. Emami J. Davies N.M. Dorkoosh F. Physicochemical, pharmaceutical and biological approaches toward designing optimized and efficient hydrophobically modified chitosan-based polymeric micelles as a nanocarrier system for targeted delivery of anticancer drugs J. Drug Target. 2013 21 693 709 10.3109/1061186X.2013.824455 23915108 · DOI
  13. [13]Supper S. Anton N. Seidel N. Riemenschnitter M. Curdy C. Vandamme T. Thermosensitive chitosan/glycerophosphate-based hydrogel and its derivatives in pharmaceutical and biomedical applications Expert Opin. Drug Deliv. 2014 11 249 267 10.1517/17425247.2014.867326 24304097 · DOI
  14. [14]Zakhem E. Raghavan S. Bitar K.N. Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold Biomaterials 2014 35 1882 1889 10.1016/j.biomaterials.2013.11.049 24315576 · DOI
  15. [15]Lacerda L. Parize A.L. Fávere V. Laranjeira M.C.M. Stulzer H.K. Development and evaluation of pH-sensitive sodium alginate/chitosan microparticles containing the antituberculosis drug rifampicin Mat. Sci. Eng. C 2014 39 161 167 10.1016/j.msec.2014.01.054 24863212 · DOI
  16. [16]Xiong Y. Yan K. Bentley W.E. Deng H.B. Du Y.M. Payne G.F. Shi X.W. Compartmentalized Multilayer Hydrogel Formation Using a Stimulus-Responsive Self-Assembling Polysaccharide ACS Appl. Mater. Inter. 2014 6 2948 2957 10.1021/am405544r 24471467 · DOI
  17. [17]Oyarzun-Ampuero F.A. Brea J. Loza M.I. Torres D. Alonso M.J. Chitosan-hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma Int. J. Pharm. 2009 381 122 129 10.1016/j.ijpharm.2009.04.009 19467809 · DOI
  18. [18]Wang M.J. Xie Y.L. Zheng Q.D. Yao S.J. A novel, potential microflora-activated carrier for a colon-specific drug delivery system and its characteristics Ind. Eng. Chem. Res. 2009 48 5276 5284 10.1021/ie801295y · DOI
  19. [19]Dima C. Cotarlet M. Alexe P. Dima S. Microencapsulation of essential oil of pimento [Pimenta dioica (L) Merr.] by chitosan/k-carrageenan complex coacervation method Innov. Food Sci. Emerg. 2014 22 203 211 10.1016/j.ifset.2013.12.020 · DOI
  20. [20]Kaihara S. Suzuki Y. Fujimoto K. In situ synthesis of polysaccharide nanoparticles via polyion complex of carboxymethyl cellulose and chitosan Colloid. Surf. B. 2011 85 343 348 10.1016/j.colsurfb.2011.03.008 21458962 · DOI
  21. [21]Pandey S. Mishra A. Raval P. Patel H. Gupta A. Shah D. Chitosan-pectin polyelectrolyte complex as a carrier for colon targeted drug delivery J. Young Pharm. 2013 5 160 166 10.1016/j.jyp.2013.11.002 24563596 PMC3930120 · DOI
  22. [22]Fukuda M. Peppas N.A. McGinity J.W. Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum Int. J. Pharm. 2006 310 90 100 10.1016/j.ijpharm.2005.11.042 16413153 · DOI
  23. [23]Ganguly K. Aminabhavi T.M. Kulkarni A.R. Colon targeting of 5-fluorouracil using polyethylene glycol cross-linked chitosan microspheres enteric coated with cellulose acetate phthalate Ind. Eng. Chem. Res. 2011 50 11797 11807 10.1021/ie201623d · DOI
  24. [24]Wu Q.X. Zhang Q.L. Lin D.Q. Yao S.J. Characterization of novel lactoferrin loaded capsules prepared with polyelectrolyte complexes Int. J. Pharm. 2013 455 124 131 10.1016/j.ijpharm.2013.07.048 23891653 · DOI
  25. [25]Hamman J.H. Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems Mar. Drugs 2010 8 1305 1322 10.3390/md8041305 20479980 PMC2866488 · DOI
  26. [26]Luo Y.C. Wang Q. Recent development of chitosan-based polyelectrolyte complexes with natural polysaccharides for drug delivery Int. J. Biol. Macromol. 2014 64 353 367 10.1016/j.ijbiomac.2013.12.017 24360899 · DOI
  27. [27]Yan S.F. Zhang K.X. Liu Z.W. Zhang X. Gan L. Cao B. Chen X.S. Cui L. Yin J.B. Fabrication of poly(l-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering J. Mater. Chem. B 2013 1 1541 1551 10.1039/c2tb00440b 32260717 · DOI
  28. [28]Ma G.P. Wang Z.L. Chen J. Yin R.X. Chen B.L. Nie J. Freeze-dried chitosan-sodium hyaluronate polyelectrolyte complex fibers as tissue engineering scaffolds New J. Chem. 2014 38 1211 1217 10.1039/c3nj00701d · DOI
  29. [29]Busilacchi A. Gigante A. Mattioli-Belmonte M. Manzotti S. Muzzarelli R. Chitosan stabilizes platelet growth factors and modulates stem cell differentiation toward tissue regeneration Carbohyd. Polym. 2013 98 665 676 10.1016/j.carbpol.2013.06.044 23987397 · DOI
  30. [31]Wedmore I. McManus J.G. Pusateri A.E. Holcomb J.B. A special report on the chitosan-based hemostatic dressing: Experience in current combat operations J. Trauma 2006 60 655 658 10.1097/01.ta.0000199392.91772.44 16531872 · DOI
  31. [32]Illum L. Chitosan and its use as a pharmaceutical excipient Pharm. Res. 1998 15 1326 1331 10.1023/A:1011929016601 9755881 · DOI
  32. [34]Costa E.M. Silva S. Costa M.R. Pereira M. Campos D.A. Odila J. Madureira A.R. Cardelle-Cobas A. Tavaria F.K. Rodrigues A.S. Chitosan mouthwash: Toxicity and in vivo validation Carbohyd. Polym. 2014 111 385 392 10.1016/j.carbpol.2014.04.046 25037365 · DOI
  33. [35]Chen C.Y. Chung Y.C. Antibacterial effect of water-soluble chitosan on representative dental pathogens Streptococcus Mutans and Lactobacilli Brevis J. Appl. Oral Sci. 2012 20 620 627 10.1590/S1678-77572012000600006 23329243 PMC3881855 · DOI
  34. [36]Kean T. Thanou M. Biodegradation, biodistribution and toxicity of chitosan Adv. Drug Deliver. Rev. 2010 62 3 11 10.1016/j.addr.2009.09.004 19800377 · DOI · Paper page
  35. [37]Hawary D.L. Motaleb M.A. Farag H. Guirguis O.W. Elsabee M.Z. Water-soluble derivatives of chitosan as a target delivery system of Tc-99m to some organs in vivo for nuclear imaging and biodistribution J. Radioanal. Nucl. Chem. 2011 290 557 567 10.1007/s10967-011-1310-9 · DOI
  36. [38]Hejazi R. Amiji M. Chitosan-based gastrointestinal delivery systems J. Control. Release 2003 89 151 165 10.1016/S0168-3659(03)00126-3 12711440 · DOI
  37. [39]Nunthanid J. Huanbutta K. Luangtana-anan M. Sriamornsak P. Limmatvapirat S. Puttipipatkhachorn S. Development of time-, pH-, and enzyme-controlled colonic drug delivery using spray-dried chitosan acetate and hydroxypropyl methylcellulose Eur. J. Pharm. Biopharm. 2008 68 253 259 10.1016/j.ejpb.2007.05.017 17616377 · DOI
  38. [40]Shu X.Z. Zhu K.J. Controlled drug release properties of ionically cross-linked chitosan beads: The influence of anion structure Int. J. Pharm. 2002 233 217 225 10.1016/S0378-5173(01)00943-7 11897426 · DOI
  39. [41]Rai G. Jain S.K. Agrawal S. Bhadra S. Pancholi S.S. Agrawal G.P. Chitosan hydrochloride based microspheres of albendazole for colonic drug delivery Pharmazie 2005 60 131 134 15739902
  40. [42]Sobol M. Bartkowiak A. de Haan B. de Vos P. Cytotoxicity study of novel water-soluble chitosan derivatives applied as membrane material of alginate microcapsules J. Biomed. Mater. Res. A 2013 101 1907 1914 10.1002/jbm.a.34500 23203606 · DOI
  41. [43]Xiao C.M. Sun F. Fabrication of distilled water-soluble chitosan/alginate functional multilayer composite microspheres Carbohyd. Polym. 2013 98 1366 1370 10.1016/j.carbpol.2013.07.068 24053815 · DOI
  42. [44]Sheng Y. He H.J. Zou H. Poly(lactic acid) nanoparticles coated with combined WGA and water-soluble chitosan for mucosal delivery of beta-galactosidase Drug Deliv. 2014 21 370 378 10.3109/10717544.2014.905653 24797098 · DOI
  43. [45]Keong L.C. Halim A.S. In vitro models in biocompatibility assessment for biomedical-grade chitosan derivatives in wound management Int. J. Mol. Sci. 2009 10 1300 1313 10.3390/ijms10031300 19399250 PMC2672031 · DOI
  44. [46]Muzzarelli R. Baldassarre V. Conti F. Ferrara P. Biagini G. Gazzanelli G. Vasi V. Biological activity of chitosan: Ultrastructural study Biomaterials 1988 9 247 252 10.1016/0142-9612(88)90092-0 3408796 · DOI
  45. [47]Henricus M.M. Fath K.R. Menzenski M.Z. Banerjee I.A. Morphology controlled growth of chitosan-bound microtubes and a study of their biocompatibility and antibacterial activity Macromol. Biosci. 2009 9 317 325 10.1002/mabi.200800220 19127599 · DOI
  46. [48]Bravo-Osuna I. Vauthier C. Farabollini A. Palmieri G.F. Ponchel G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles Biomaterials 2007 28 2233 2243 10.1016/j.biomaterials.2007.01.005 17261330 · DOI
  47. [49]Meng-Lund E. Muff-Westergaard C. Sander C. Madelung P. Jacobsen J. A mechanistic based approach for enhancing buccal mucoadhesion of chitosan Int. J. Pharm. 2014 461 280 285 10.1016/j.ijpharm.2013.10.047 24291123 · DOI
  48. [50]Gulbake A. Jain S.K. Chitosan: A potential polymer for colon-specific drug delivery system Expert Opin. Drug Deliv. 2012 9 713 729 10.1517/17425247.2012.682148 22530707 · DOI
  49. [51]Wittaya-areekul S. Kruenate J. Prahsarn C. Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone Int. J. Pharm. 2006 312 113 118 10.1016/j.ijpharm.2006.01.003 16490331 · DOI
  50. [52]Fernandes M. Gonçalves I.C. Nardecchia S. Amaral I.F. Barbosa M.A. Martins M.C.L. Modulation of stability and mucoadhesive properties of chitosan microspheres for therapeutic gastric application Int. J. Pharm. 2013 454 116 124 10.1016/j.ijpharm.2013.06.068 23850814 · DOI
  51. [53]Muzzarelli R. Human enzymatic activities related to the therapeutic administration of chitin derivatives Cell. Mol. Life Sci. 1997 53 131 140 10.1007/PL00000584 9118001 PMC11147374 · DOI
  52. [54]Sinha V.R. Kumria R. Polysaccharides in colon-specific drug delivery Int. J. Pharm. 2001 224 19 38 10.1016/S0378-5173(01)00720-7 11472812 · DOI · Paper page
  53. [55]Tozaki H. Komoike J. Tada C. Maruyama T. Terabe A. Suzuki T. Yamamoto A. Muranishi S. Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon J. Pharm. Sci. 1997 86 1016 1021 10.1021/js970018g 9294815 · DOI
  54. [56]Orienti I. Cerchiara T. Luppi B. Bigucci F. Zuccari G. Zecchi V. Influence of different chitosan salts on the release of sodium diclofenac in colon-specific delivery Int. J. Pharm. 2002 238 51 59 10.1016/S0378-5173(02)00060-1 11996810 · DOI
  55. [57]Yang Y.M. Hu W. Wang X.D. Gu X.S. The controlling biodegradation of chitosan fibers by N-acetylation in vitro and in vivo J. Mater. Sci.-Mater. M. 2007 18 2117 2121 10.1007/s10856-007-3013-x 17619982 · DOI
  56. [58]Xu J. McCarthy S.P. Gross R.A. Kaplan D.L. Chitosan film acylation and effects on biodegradability Macromolecules 1996 29 3436 3440 10.1021/ma951638b · DOI
  57. [59]Zhu L.Y. Lin D.Q. Yao S.J. Biodegradation of polyelectrolyte complex films composed of chitosan and sodium cellulose sulfate as the controllable release carrier Carbohyd. Polym. 2010 82 323 328 10.1016/j.carbpol.2010.04.062 · DOI
  58. [61]Ramaraj B. Radhakrishnan G. Hydrogel capsules for sustained drug-release J. Appl. Polym. Sci. 1994 51 979 988 10.1002/app.1994.070510602 · DOI
  59. [62]II’Ina A.V. Varlamov V.P. Chitosan-based polyelectrolyte complexes: A review Appl. Biochem. Microbiol. 2005 41 5 11 10.1007/s10438-005-0002-z 15810726 · DOI
  60. [63]Silva C.L. Pereira J.C. Ramalho A. Pais A.A.C.C. Sousa J.J.S. Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization J. Membrane Sci. 2008 320 268 279 10.1016/j.memsci.2008.04.011 · DOI
  61. [65]Yoshizawa T. Shin-ya Y. Hong K. Kajiuchi T. pH- and temperature-sensitive release behaviors from polyelectrolyte complex films composed of chitosan and PAOMA copolymer Eur. J. Pharm. Biopharm. 2005 59 307 313 10.1016/j.ejpb.2004.08.002 15661503 · DOI
  62. [66]Feng Q. Zeng G. Yang P. Wang C. Cai J. Self-assembly and characterization of polyelectrolyte complex films of hyaluronic acid/chitosan Colloid. Surf. A 2005 257–258 85 88 10.1016/j.colsurfa.2004.10.099 · DOI
  63. [67]Tozaki H. Odoriba T. Okada N. Fujita T. Terabe A. Suzuki T. Okabe S. Muranishi S. Yamamoto A. Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats J. Control. Release 2002 82 51 61 10.1016/S0168-3659(02)00084-6 12106976 · DOI
  64. [68]Fetih G. Lindberg S. Itoh K. Okada N. Fujita T. Habib F. Artersson P. Attia M. Yamamoto A. Improvement of absorption enhancing effects of n-dodecyl-β-d-maltopyranoside by its colon-specific delivery using chitosan capsules Int. J. Pharm. 2005 293 127 135 10.1016/j.ijpharm.2004.12.017 15778050 · DOI
  65. [69]Huang B.B. Li G.F. Luo J.H. Duan L. Nobuaki K. Akira Y. Permeabilities of rebamipide via rat intestinal membranes and its colon specific delivery using chitosan capsule as a carrier World J. Gastroenterol. 2008 14 4928 4937 10.3748/wjg.14.4928 18756602 PMC2739947 · DOI
  66. [71]Wu Q.X. Yao S.J. Novel NaCS-CS-PPS microcapsules as a potential enzyme-triggered release carrier for highly-loading 5-ASA Colloid. Surf. B 2013 109 147 153 10.1016/j.colsurfb.2013.03.035 23640018 · DOI
  67. [72]Fukui Y. Maruyama T. Iwamatsu Y. Fujii A. Tanaka T. Ohmukai Y. Matsuyama H. Preparation of monodispersed polyelectrolyte microcapsules with high encapsulation efficiency by an electrospray technique Colloid. Surf. A 2010 370 28 34 10.1016/j.colsurfa.2010.08.039 · DOI
  68. [73]Simi S.P. Saraswathi R. Sankar C. Krishnan P.N. Dilip C. Ameena K. Formulation and evaluation of Albendazole microcapsules for colon delivery using chitosan Asian Pac. J. Trop. Med. 2010 3 374 378 10.1016/S1995-7645(10)60091-0 · DOI
  69. [74]Xie Y.L. Wang M.J. Yao S.J. Preparation and characterization of biocompatible microcapsules of sodium cellulose sulfate/chitosan by means of layer-by-layer self-assembly Langmuir 2009 25 8999 9005 10.1021/la9014338 19583223 · DOI
  70. [75]Devi N. Maji T.K. Effect of crosslinking agent on Neem (Azadirachta Indica A. Juss.) Seed Oil (NSO) encapsulated microcapsules kappa-carrageenan and chitosan polyelectrolyte complex J. Macromol. Sci. A 2009 46 1114 1121 10.1080/10601320903245524 · DOI
  71. [76]Wu Q.X. Li M.Z. Yao S.J. Performances of NaCS-WSC protein drug microcapsules with different degree of substitution of NaCS using sodium polyphosphate as cross-linking agent Cellulose 2014 21 1897 1908 10.1007/s10570-014-0209-3 · DOI
  72. [77]Yu W.T. Song H.Y. Zheng G.S. Liu X.D. Zhang Y. Ma X.J. Study on membrane characteristics of alginate-chitosan microcapsule with cell growth J. Membr. Sci. 2011 377 214 220 10.1016/j.memsci.2011.04.053 · DOI
  73. [78]Cook M.T. Tzortzis G. Charalampopoulos D. Khutoryanskiy V.V. Production and evaluation of dry alginate-chitosan microcapsules as an enteric delivery vehicle for probiotic bacteria Biomacromolecules 2011 12 2834 2840 10.1021/bm200576h 21574635 · DOI
  74. [79]Argin S. Kofinas P. Lo Y.M. The cell release kinetics and the swelling behavior of physically crosslinked xanthan-chitosan hydrogels in simulated gastrointestinal conditions Food Hydrocolloid. 2014 40 138 144 10.1016/j.foodhyd.2014.02.018 · DOI
  75. [80]Balabushevich N.G. Pechenkin M.A. Shibanova E.D. Volodkin D.V. Mikhalchik E.V. Multifunctional polyelectrolyte microparticles for oral insulin delivery Macromol. Biosci. 2013 13 1379 1388 10.1002/mabi.201300207 23861285 · DOI
  76. [81]Barakat N.S. Almurshedi A.S. Preparation and characterization of chitosan microparticles for oral sustained delivery of Gliclazide: In Vitro/In Vivo evaluation Drug Dev. Res. 2011 72 235 246 10.1002/ddr.20389 · DOI
  77. [82]Vasiliu S. Popa M. Luca C. Evaluation of retention and release processes of two antibiotics from the biocompatible core-shell microparticles Eur. Polym. J. 2008 44 3894 3898 10.1016/j.eurpolymj.2008.07.040 · DOI
  78. [84]Li J. Huang P. Chang L. Long X. Dong A. Liu J. Chu L. Hu F. Liu J. Deng L. Tumor targeting and pH-responsive polyelectrolyte complex nanoparticles based on hyaluronic acid-paclitaxel conjugates and chitosan for oral delivery of paclitaxel Macromol. Res. 2013 21 1331 1337 10.1007/s13233-013-1171-x · DOI
  79. [85]Kumar A. Ahuja M. Carboxymethyl gum kondagogu-chitosan polyelectrolyte complex nanoparticles: Preparation and characterization Int. J. Biol. Macromol. 2013 62 80 84 10.1016/j.ijbiomac.2013.08.035 23994791 · DOI
  80. [86]Arora S. Gupta S. Narang R.K. Budhiraja R.D. Amoxicillin loaded chitosan-alginate polyelectrolyte complex nanoparticles as mucopenetrating delivery system for H. Pylori Sci. Pharm. 2011 79 673 694 10.3797/scipharm.1011-05 21886911 PMC3163361 · DOI
  81. [87]Paliwal R. Paliwal S.R. Agrawal G.P. Vyas S.P. Chitosan nanoconstructs for improved oral delivery of low molecular weight heparin: In vitro and in vivo evaluation Int. J. Pharm. 2012 422 179 184 10.1016/j.ijpharm.2011.10.048 22079712 · DOI
  82. [88]Li C. Newman R.A. Wu Q.P. Ke S. Chen W. Hutto T. Kan Z. Brannan M.D. Charnsangavej C. Wallace S. Biodistribution of paclitaxel and poly(l-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor Cancer Chemoth. Pharm. 2000 46 416 422 10.1007/s002800000168 11127947 · DOI
  83. [89]Jain A.K. Swarnakar N.K. Godugu C. Singh R.P. Jain S. The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen Biomaterials 2011 32 503 515 10.1016/j.biomaterials.2010.09.037 20934747 · DOI · Paper page
  84. [90]Shelly Ahuja M. Kumar A. Gum ghatti-chitosan polyelectrolyte nanoparticles: Preparation and characterization Int. J. Biol. Macromol. 2013 61 411 415 10.1016/j.ijbiomac.2013.07.022 23924761 · DOI
  85. [91]Guo R. Chen L.L. Cai S.S. Liu Z.H. Zhu Y. Xue W. Zhang Y.M. Novel alginate coated hydrophobically modified chitosan polyelectrolyte complex for the delivery of BSA J. Mater. Sci.-Mater. Med. 2013 24 2093 2100 10.1007/s10856-013-4977-3 23779155 · DOI
  86. [92]Anitha A. Sreeranganathan M. Chennazhi K.P. Lakshmanan V. Jayakumar R. In vitro combinatorial anticancer effects of 5-fluorouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles toward colon cancer and in vivo pharmacokinetic studies Eur. J. Pharm. Biopharm. 2014 88 238 251 10.1016/j.ejpb.2014.04.017 24815764 · DOI

Cited by

Sorted by citations

Authors
Wu, Q.-X., Lin, D.-Q., & Yao, S.-J.
Affiliations
  • Anhui University (CN)
  • Collaborative Innovation Center of Chemical Science and Engineering Tianjin (CN)
Corresponding author
Yao, Shan-Jing
ORCID
Venue
Marine Drugs
Publisher
MDPI AG
Published
2014-12-19
Volume
12
Issue
12
Pages
6236-6253
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md12126236
PMC
PMC4278227
OpenAlex
W2081258761
Cited by
126
References
0
Citations by year
2026: 4 · 2025: 6 · 2024: 10 · 2023: 12 · 2022: 21 · 2021: 18 · 2020: 9 · 2019: 16 · 2018: 16 · 2017: 6 · 2016: 6 · 2015: 2
FWCI
0.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Marine Drugs (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China
  • Ministry of Education of the People's Republic of China
  • Anhui University
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
chitosan, water-soluble chitosan derivatives, polyelectrolyte complexes, drug carriers, drug delivery, controlled release, targeted drug delivery, microcapsules, capsules, cinema, biomaterials
MeSH terms
Animals, Drug Carriers, Humans, Polymers, Water, Chitosan

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review