Assessment of the Antimicrobial Activity of Algae Extracts on Bacteria Responsible of External Otitis
Open accessAbstract
External otitis is a diffuse inflammation around the external auditory canal and auricle, which is often occurred by microbial infection. This disease is generally treated using antibiotics, but the frequent occurrence of antibiotic resistance requires the development of new antibiotic agents. In this context, unexplored bioactive natural candidates could be a chance for the production of targeted drugs provided with antimicrobial activity. In this paper, microbial pathogens were isolated from patients with external otitis using ear swabs for over one year, and the antimicrobial activity of the two methanol extracts from selected marine (Dunaliella salina) and freshwater (Pseudokirchneriella subcapitata) microalgae was tested on the isolated pathogens. Totally, 114 bacterial and 11 fungal strains were isolated, of which Staphylococcus spp. (28.8%) and Pseudomonas aeruginosa (P. aeruginosa) (24.8%) were the major pathogens. Only three Staphylococcus aureus (S. aureus) strains and 11 coagulase-negative Staphylococci showed resistance to methicillin. The two algal extracts showed interesting antimicrobial properties, which mostly inhibited the growth of isolated S. aureus, P. aeruginosa, Escherichia coli, and Klebsiella spp. with MICs range of 1.4 × 109 to 2.2 × 1010 cells/mL. These results suggest that the two algae have potential as resources for the development of antimicrobial agents.
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Substances synthesized by Dunaliella primolecta show antibacterial activity against S. aureus and other bacterial strains.
“Substances synthesized by Dunaliella primolecta also showed antibacterial activity against S. aureus and against other bacterial strains [260].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [260]
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References 45 · Cited by 56
Research works printed but not linked: 3
- [37]Amaro H.M. Guedes A.C. Malcata F.X. Antimicrobial activities of microalgae: An invited review Science Against Microbial Pathogens: Communicating Current Research and Technological Advances Méndez-Vilas A. Formatex Research Center Badajoz, Spain 2011 1272 1280
- [42]Clinical and Laboratory Standards Institute (CLSI) Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard—Eleventh Edition. Document M02-A11 Clinical and Laboratory Standards Institute (CLSI) Wayne, PA, USA 2012
- [43]Clinical and Laboratory Standards Institute (CLSI) Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard—Ninth Edition. Document M07-A9 Clinical and Laboratory Standards Institute (CLSI) Wayne, PA, USA 2012
- Authors
- Pane, G., Cacciola, G., Giacco, E., Mariottini, G., & Coppo, E.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Mariottini, Gian
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2015-10-20
- Volume
- 13
- Issue
- 10
- Pages
- 6440-6452
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC4626699
- OpenAlex
- W1753471581
- Cited by
- 56
- References
- 45
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 4 · 2016: 4
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- otitis externa, antimicrobial activity, algal extracts, Dunaliella salina, Pseudokirchneriella subcapitata, Staphylococcus aureus, Pseudomonas aeruginosa, methicillin resistance, coagulase-negative staphylococci, Escherichia coli, Klebsiella, marine microalgae, freshwater microalgae, methanol extract, antibiotic resistance, natural antimicrobials
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anti-Infective Agents, Bacteria, Female, Fungi, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Otitis Externa, Plant Extracts, Drug Resistance, Bacterial, Young Adult, Microalgae
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