New Metabolites and Bioactive Actinomycins from Marine-Derived Streptomyces sp. ZZ338
Open accessAbstract
An extract prepared from the culture of a marine-derived actinomycete Streptomyces sp. ZZ338 was found to have significant antimicrobial and antiproliferative activities. A chemical investigation of this active extract resulted in the isolation of three known bioactive actinomycins (1–3) and two new metabolites (4 and 5). The structures of the isolated compounds were identified as actinomycins D (1), V (2), X0β (3), 2-acetylamino-3-hydroxyl-4-methyl-benzoic acid methyl ester (4), and N-1S-(4-methylaminophenylmethyl)-2-oxo-propyl acetamide (5) based on their nuclear magnetic resonance (NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS) data as well as their optical rotation. This class of new compound 5 had never before been found from a natural resource. Three known actinomycins showed activities in inhibiting the proliferation of glioma cells and the growth of methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans and are responsible for the activity of the crude extract. Actinomycin D (1) was also found to downregulate several glioma metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis, suggesting that targeting multiple tumor metabolic regulators might be a new anti-glioma mechanism of actinomycin D. This is the first report of such a possible mechanism for the class of actinomycins.
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Dactinomycin downregulates several glioma metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis.
“Clinically useful agents from these families (Figure 3, Figure 8; Table 2) include peptolides, dactinomycin, was found to downregulate several glioma metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis, suggesting that targeting multiple tumor metabolic regulators might be a new anti-glioma mechanism of actinomycin D [195].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [195]
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- Authors
- Zhang, X., Ye, X., Chai, W., Lian, X.-Y., & Zhang, Z.
- Affiliations
- Zhejiang University (CN)
- Corresponding author
- Lian, Xiao-Yuan
- Zhang, Zhizhen
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2016-10-11
- Volume
- 14
- Issue
- 10
- Pages
- 181
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC5082329
- OpenAlex
- W2531699720
- Cited by
- 58
- References
- 33
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 12 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 4
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- actinomycin, marine actinomycetes, actinomycin D, new natural products, antimicrobial activity, antiproliferative activity, glioma, methicillin-resistant Staphylococcus aureus, Candida albicans, Escherichia coli, cancer metabolism, glycolysis, glutaminolysis, lipogenesis, structure elucidation
- MeSH terms
- Animals, Anti-Infective Agents, Antineoplastic Agents, Candida albicans, Dactinomycin, Drug Screening Assays, Antitumor, Escherichia coli, Humans, Oceans and Seas, Staphylococcus aureus, Streptomyces, Structure-Activity Relationship, Tumor Cells, Cultured, Inhibitory Concentration 50, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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