Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
Open accessAbstract
Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-α and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-α and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-κB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IκBα and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-κB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation.
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Scytonemin (44) has anti-photoaging and anti-inflammatory activities.
“Recently, the promising anti-photoaging and anti-inflammatory activities of scytonemin (44) were described [122].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [122]
The Discussion (page unavailable) says the study demonstrated anti-inflammatory activity in vitro and in vivo and describes scytonemin as a UV sunscreen agent. It does not report an anti-photoaging effect; UV protection and a general mention of anti-wrinkle properties do not establish that part of the claim. (LLM, conf=0.88)
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- Authors
- Kang, M. R., Jo, S. A., Lee, H., Yoon, Y. D., Kwon, J.-H., Yang, J.-W., Choi, B. J., Park, K. H., Lee, M. Y., Lee, C. W., Lee, K.-R., & Kang, J. S.
- Affiliations
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Corresponding author
- Kang, Jong Soon
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2020-06-04
- Volume
- 18
- Issue
- 6
- Pages
- 300
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC7344946
- OpenAlex
- W3033882348
- Cited by
- 35
- References
- 27
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 3 · 2023: 2 · 2022: 10 · 2021: 4 · 2020: 1
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Korea Research Institute of Bioscience and Biotechnology (KGS9982022)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- scytonemin, anti-inflammatory activity, skin inflammation, NF-κB signaling, TNF-α, inducible nitric oxide synthase, nitric oxide, lipopolysaccharide, macrophages, IκBα degradation, p65 nuclear translocation, cyanobacteria, skin care ingredients
- MeSH terms
- RAW 264.7 Cells, NF-KappaB Inhibitor alpha, Animals, Anti-Inflammatory Agents, Indoles, Lipopolysaccharides, Mice, Inbred BALB C, Nitric Oxide, Phenols, Sunscreening Agents, Tetradecanoylphorbol Acetate, Tumor Necrosis Factor-alpha, NF-kappa B, Mice, Nitric Oxide Synthase Type II
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