Antioxidant and antiproliferative activities of heterofucans from the seaweed Sargassum filipendula
Open accessAbstract
Fucan is a term used to denominate a type of polysaccharide which contains substantial percentages of l-fucose and sulfate ester groups. We obtained five heterofucans from Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. These heterofucans are composed mainly of fucose, glucose, glucuronic acid, galactose and sulfate. These fucans did not show anticoagulant activity in PT and aPTT tests. Their antioxidant activity was evaluated using the follow tests; total antioxidant capacity, scavenging hydroxyl and superoxide radicals, reducing power and ferrous ion [Fe(II)] chelating. All heterofucans displayed considerable activity, especially SF-1.0v which showed the most significant antioxidant potential with 90.7 ascorbic acid equivalents in a total antioxidant capacity test and similar activity when compared with vitamin C in a reducing power assay. The fucan antiproliferative activity was performed with HeLa, PC3 and HepG2 cells using MTT test. In all tested conditions the heterofucans exhibited a dose-dependent effect. The strongest inhibition was observed in HeLa cells, where SF-1.0 and SF-1.5 exhibited considerable activity with an IC50 value of 15.69 and 13.83 μM, respectively. These results clearly indicate the beneficial effect of S. filipendula polysaccharides as antiproliferative and antioxidant. Further purification steps and additional studies on structural features as well as in vivo experiments are needed to test the viability of their use as therapeutic agents.
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Fucoidan from Sargassum filipendula showed antiproliferative activity on HeLa cells and induced apoptosis by mitochondrial release of AIF into cytosol, but did not activate caspases.
“The fucoidan from Sargassum filipendula showed antiproliferative activity on HeLa cells [39] and induced apoptosis by mitochondrial release of apoptosis inducing factor (AIF) into cytosol, but was not able to activate caspases [40].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [39]
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References 38 · Cited by 155
- Authors
- Costa, L. S., Fidelis, G. P., Telles, C. B. S., Dantas-Santos, N., Camara, R. B. G., Cordeiro, S. L., Costa, M. S. S. P., Almeida-Lima, J., Melo-Silveira, R. F., Oliveira, R. M., Albuquerque, I. R. L., Andrade, G. P. V., & Rocha, H. A. O.
- Affiliations
- Instituto Federal do Rio Grande do Norte (BR)
- Universidade Federal do Rio Grande do Norte (BR)
- Laboratório de Biotecnologia de Polímeros Naturais (BIOPOL), Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil
- Corresponding author
- Rocha, Hugo Alexandre Oliveira
- ORCID
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2011-06-07
- Volume
- 9
- Issue
- 6
- Pages
- 952-966
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC3131554
- OpenAlex
- W2020587056
- Cited by
- 155
- References
- 38
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 15 · 2021: 11 · 2020: 12 · 2019: 14 · 2018: 6 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 12 · 2012: 9
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- Sargassum filipendula, seaweed polysaccharides, antioxidant activity, antiproliferative activity, fucan, free radical scavenging, reducing power, ferrous ion chelation, anticoagulant activity, HeLa cells, PC-3 cells, HepG2 cells, proteolytic digestion, acetone precipitation
- MeSH terms
- Anticoagulants, Antioxidants, Dose-Response Relationship, Drug, Fucose, Galactose, Glucose, HeLa Cells, Humans, Partial Thromboplastin Time, Polysaccharides, Seaweed, Sulfates, Glucuronic Acid, Sargassum, Cell Line, Tumor, Cell Proliferation, Hep G2 Cells
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