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Oral Immunotherapy (OIT): A Personalized Medicine

Mori, Francesca, Barni, Simona, Liccioli, Giulia, Novembre, Elio·2019·Medicina
DOI 10.3390/medicina55100684PMC PMC6843277
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Abstract

Oral Immunotherapy (OIT), a promising allergen-specific approach in the management of Food Allergies (FA), is based on the administration of increasing doses of the culprit food until reaching a maintenance dose. Each step should be adapted to the patient, and OIT should be considered an individualized treatment. Recent studies focused on the standardization and identification of novel biomarkers in order to correlate endotypes with phenotypes in the field of FA.

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Research works printed but not linked: 95

  1. Gamazo, 2018, New pharmaceutical approaches for the treatment of food allergies, Expert Opin. Drug Deliv., 15, 675, 10.1080/17425247.2016.1247805 · DOI
  2. Cipriani, 2015, Food Allergy in childhood: Phenotypes, prevention and treatment, Pediatr. Allergy Immunol., 26, 711, 10.1111/pai.12514 · DOI
  3. Wood, 2016, Food allergen immunotherapy: Current status and prospects for the future, J. Allergy Clin. Immunol., 137, 973, 10.1016/j.jaci.2016.01.001 · DOI
  4. PALISADE Group of Clinical Investigators, Vickery, B.P., Vereda, A., Casale, T.B., Beyer, K., du Toit, G., Hourihane, J.O., Jones, S.M., Shreffler, W.G., and Marcantonio, A. (2018). AR101 Oral Immunotherapy for Peanut Allergy. N. Engl. J. Med., 379, 1991–2001. · DOI
  5. Burbank, 2016, Allergen Immunotherapy for food allergy, Immunol. Allergy Clin. N. Am., 36, 55, 10.1016/j.iac.2015.08.007 · DOI
  6. Narisety, 2015, A randomized, double blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy, J. Allergy Clin. Immunol., 135, 1275, 10.1016/j.jaci.2014.11.005 · DOI
  7. Wasserman, 2014, Oral immunotherapy for peanut allergy: Multipractice experience with epinephrine-treated reactions, J. Allergy Clin. Immunol. Pract., 2, 91, 10.1016/j.jaip.2013.10.001 · DOI
  8. Barni, 2019, Low-Dose Oral Food Challenge with Hazelnut: Efficacy and Tolerability in Children, Int. Arch. Allergy Immunol., 178, 97, 10.1159/000493019 · DOI
  9. Martorell, 2017, Expert panel selected from members of the Spanish Society of Pediatric Allergology, Asthma and Clinical Immunology (SEICAP) and the Spanish Society of Allergology and Clinical Immunology (SEAIC). Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase, J. Investig. Allergol. Clin. Immunol., 27, 225, 10.18176/jiaci.0177 · DOI
  10. Vickery, 2014, Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy, J. Allergy Clin. Immunol., 133, 468, 10.1016/j.jaci.2013.11.007 · DOI
  11. Skripak, 2008, A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow’s milk allergy, J. Allergy Clin. Immunol., 122, 1154, 10.1016/j.jaci.2008.09.030 · DOI
  12. Keet, 2013, Long-term follow-up of oral immunotherapy for cow’s milk allergy, J. Allergy Clin. Immunol., 132, 737, 10.1016/j.jaci.2013.05.006 · DOI
  13. Burks, 2015, Consortium of Food Allergy Research. Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial, J. Allergy Clin. Immunol., 135, 1240, 10.1016/j.jaci.2014.12.1917 · DOI
  14. Jones, 2016, Consortium of Food Allergy Research (CoFAR). Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy, J. Allergy Clin. Immunol., 137, 1117, 10.1016/j.jaci.2015.12.1316 · DOI
  15. Mikkelsen, 2015, Monitoring the impact of cow’s milk allergy on children and their families with the FLIP questionnaire—A six-month follow-up study, Pediatr. Allergy Immunol., 26, 409, 10.1111/pai.12406 · DOI
  16. Terracciano, 2012, Oral immunotherapy for IgE-mediated cow’s milk allergy: A systematic review and meta-analysis, Clin. Exp. Allergy, 42, 363, 10.1111/j.1365-2222.2011.03948.x · DOI
  17. Romantsik, 2014, Oral and sublingual immunotherapy for egg allergy, Cochrane Database Syst. Rev., 11, CD010638
  18. Nurmatov, 2014, Effectiveness and safety of orally administered immunotherapy for food allergies: A systematic review and meta-analysis, Br. J. Nutr., 111, 12, 10.1017/S0007114513002353 · DOI
  19. Alvaro, 2014, Life-threatening anaphylaxis to egg and milk oral immunotherapy in asthmatic teenagers, Ann. Allergy Asthma Immunol., 113, 482, 10.1016/j.anai.2014.07.010 · DOI
  20. Nieto, 2010, Life-threatening asthma reaction caused by desensitization to milk, Allergy, 65, 1342, 10.1111/j.1398-9995.2010.02348.x · DOI
  21. Alsina, 2013, Safety and predictors of adverse events during oral immunotherapy for milk allergy: Severity of reaction at oral challenge, specific IgE and prick test, Clin. Exp. Allergy, 43, 92, 10.1111/cea.12012 · DOI
  22. Hofmann, 2009, Safety of a peanut oral immunotherapy protocol in children with peanut allergy, J. Allergy Clin. Immunol., 124, 286, 10.1016/j.jaci.2009.03.045 · DOI
  23. Trendelenburg, 2014, Efficacy and safety balance of oral and sublingual immunotherapy in food allergy, Curr. Treat. Options Allergy, 1, 117, 10.1007/s40521-014-0018-9 · DOI
  24. Jones, 2009, Clinical efficacy and immune regulation with peanut oral immunotherapy, J. Allergy Clin. Immunol., 124, 292, 10.1016/j.jaci.2009.05.022 · DOI
  25. Varshney, 2011, A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response, J. Allergy Clin. Immunol., 127, 654, 10.1016/j.jaci.2010.12.1111 · DOI
  26. Rigbi, 2017, Changes in patient quality of life during oral immunotherapy for food allergy, Allergy., 72, 1883, 10.1111/all.13211 · DOI
  27. Alvaro, 2015, Impact of oral immunotherapy on quality of life in egg allergic children, Pediatr. Allergy Immunol., 26, 291, 10.1111/pai.12355 · DOI
  28. Burks, 2012, Consortium of Food Allergy Research (CoFAR). Oral immunotherapy for treatment of egg allergy in children, N. Engl. J. Med., 367, 233, 10.1056/NEJMoa1200435 · DOI
  29. Thyagarajan, 2012, Evidence of pathway-specific basophil anergy induced by peanut oral immunotherapy in peanut-allergic children, Clin. Exp. Allergy, 42, 1197, 10.1111/j.1365-2222.2012.04028.x · DOI
  30. Vickery, 2013, Peanut oral immuotherapy modifies IgE and IgG4 response to major peanut allergens, J. Allergy Clin. Immunol., 131, 128, 10.1016/j.jaci.2012.10.048 · DOI
  31. Begin, 2015, Changes in peanut-specific T-cell clonotype with oral immunotherapy, J. Allergy Clin. Immunol., 135, 1636, 10.1016/j.jaci.2015.03.010 · DOI
  32. Syed, 2014, Peanut oral immunotherapy results in increased antigen-induced regulator T-cell function and hypomethylation of forkhead box pro-tein 3 (FOXP3), J. Allergy Clin. Immunol., 133, 500, 10.1016/j.jaci.2013.12.1037 · DOI
  33. Gorelik, 2015, Suppression of the immunologic response to peanut during oral immunotherapy is often transient, J. Allergy Clin. Immunol., 135, 1283, 10.1016/j.jaci.2014.11.010 · DOI
  34. 2014, Evolución y grado de satisfacción tras inducción de tolerancia oral con huevo, Allergol. Immunopathol. Proc., 1, 281
  35. Martorell, 2013, Persistencia de la tolerancia adquirida tras tratamiento de mantenimiento de un protocolo de inducción de tolerancia oral con dosis máxima de 17 mL de clara pasteurizada, Allergol. Immunopathol. Proc., 1, 240
  36. Fuentes, 2014, Inmunoterapia oral con huevo (ITOH) en niños con alergia persistente. Valoración de diferentes pautas de mantenimiento, J. Investig. Allergol. Clin. Immunol., 24, 73
  37. Urra, 2011, Oral rush desensitization to egg: Efficacy and safety, Clin. Exp. Allergy, 41, 1289, 10.1111/j.1365-2222.2011.03722.x · DOI
  38. Muraro, 2007, EAACI Task Force on Anaphylaxis in Children. The management of anaphylaxis in childhood: Position paper of the European Academy of Allergology and Clinical Immunology, Allergy, 62, 857, 10.1111/j.1398-9995.2007.01421.x · DOI
  39. 2007, Oral rush desensitization to cow milk. Following of desensitized patients during three years, Allergol. Immunopathol. (Madr.), 35, 174, 10.1157/13110311 · DOI
  40. Meglio, 2013, Oral food desensitization in children with IgE-mediated hen’s egg-allergy: A new protocol with raw hen’s egg, Pediatr. Allergy Immunol., 24, 75, 10.1111/j.1399-3038.2012.01341.x · DOI
  41. 2014, Long term follow up of patients that have received immunotherapy with cow’s milk, Allergy, 69, 282
  42. Meglio, 2004, A protocol for oral desensitization in children with IgE-mediated cow’s milk allergy, Allergy, 59, 980, 10.1111/j.1398-9995.2004.00542.x · DOI
  43. Longo, 2008, Specific oral tolerance induction in children with very severe cow’s milk-induced reactions, J. Allergy Clin. Immunol., 121, 343, 10.1016/j.jaci.2007.10.029 · DOI
  44. Narisety, 2009, Open-label maintenance after milk oral immunotherapy for IgE-mediated cow’s milk allergy, J. Allergy Clin. Immunol., 124, 610, 10.1016/j.jaci.2009.06.025 · DOI
  45. Pajno, 2010, Oral immunotherapy for cow’s milk allergy with a weekly up-dosing regimen: A randomized single-blind controlled study, Ann. Allergy Asthma Immunol., 105, 376, 10.1016/j.anai.2010.03.015 · DOI
  46. Martorell, 2011, Oral desensitization as a useful treatment in 2-year-old children with cow’s milk allergy, Clin. Exp. Allergy, 41, 1297, 10.1111/j.1365-2222.2011.03749.x · DOI
  47. Keet, 2012, The safety and efficacy of sublingual and oral immunotherapy for milk allergy, J. Allergy Clin. Immunol., 129, 448, 10.1016/j.jaci.2011.10.023 · DOI
  48. Goldberg, 2015, Efficacy of baked milk oral immunotherapy in baked milk–reactive allergic patients, J. Allergy Clin. Immunol., 136, 1601, 10.1016/j.jaci.2015.05.040 · DOI
  49. Takahashi, 2016, Two-weeks-sustained unresponsiveness by oral immunotherapy using microwave heated cow’s milk for children with cow’s milk allergy, Allergy Asthma Clin. Immunol., 12, 44, 10.1186/s13223-016-0150-0 · DOI
  50. Ebrahimi, 2017, The Efficacy of Oral Immunotherapy in Patients with Cow’s Milk Allergy, Iran. J. Allergy Asthma Immunol., 16, 183
  51. Amat, 2017, Is a slow-progression baked-milk protocol of oral immunotherapy always a safe option for children with cow’s milk allergy? A randomized controlled trial, Clin. Exp. Allergy, 47, 1491, 10.1111/cea.13022 · DOI
  52. Efron, 2018, A Structured Gradual Exposure Protocol to Baked and Heated Milk in the Treatment of Milk Allergy, J. Pediatr., 203, 204, 10.1016/j.jpeds.2018.07.091 · DOI
  53. Inuo, 2018, Oral Immunotherapy Using Partially Hydrolyzed Formula for Cow’s Milk Protein Allergy: A Randomized, Controlled Trial, Int. Arch. Allergy Immunol., 177, 259, 10.1159/000490804 · DOI
  54. Mota, 2018, Cow’s milk oral immunotherapy in real life: 8-year long-term follow-up study, Asia Pac. Allergy, 8, e28, 10.5415/apallergy.2018.8.e28 · DOI
  55. Kauppila, 2019, Outcome of oral immunotherapy for persistent cow’s milk allergy from 11 years of experience in Finland, Pediatr. Allergy Immunol., 30, 356, 10.1111/pai.13025 · DOI
  56. Mazer, 2019, Adverse Events in Oral Immunotherapy for the Desensitization of Cow’s Milk Allergy in Children: A Randomized Controlled Trial, J. Allergy Clin. Immunol. Pract., 7, 1912, 10.1016/j.jaip.2019.02.007 · DOI
  57. Berti, 2019, Early oral immunotherapy in infants with cow’s milk protein allergy, Pediatr. Allergy Immunol., 30, 572, 10.1111/pai.13057 · DOI
  58. Blumchen, 2010, Oral peanut immunotherapy in children with peanut anaphylaxis, J. Allergy Clin. Immunol., 126, 83, 10.1016/j.jaci.2010.04.030 · DOI
  59. Anagnostou, 2011, Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome, Clin. Exp. Allergy, 41, 1273, 10.1111/j.1365-2222.2011.03699.x · DOI
  60. Anagnostou, 2014, Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): A phase 2 randomised controlled trial, Lancet, 383, 1297, 10.1016/S0140-6736(13)62301-6 · DOI
  61. Kukkonen, 2017, Double-blind placebo-controlled challenge showed that peanut oral immunotherapy was effective for severe allergy without negative effects on airway inflammation, Acta Paediatr., 106, 274, 10.1111/apa.13668 · DOI
  62. Vickery, 2017, Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective, J. Allergy Clin. Immunol., 139, 173, 10.1016/j.jaci.2016.05.027 · DOI
  63. Bird, 2018, Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial, J. Allergy Clin. Immunol. Pract., 6, 476, 10.1016/j.jaip.2017.09.016 · DOI
  64. Nachshon, 2018, Long-Term outcome of Peanut Oral Immunotherapy—Real Life Experience, Pediatr. Allergy Immunol., 29, 519, 10.1111/pai.12914 · DOI
  65. Nagakura, 2018, Low-dose oral immunotherapy for children with anaphylactic peanut allergy in Japan, Pediatr. Allergy Immunol., 29, 512, 10.1111/pai.12898 · DOI
  66. Nagakura, 2018, Oral Immunotherapy in Japanese Children with Anaphylactic Peanut Allergy, Int. Arch. Allergy Immunol., 175, 181, 10.1159/000486310 · DOI
  67. Anvari, 2018, Peanut oral immunotherapy dose variations do not result in allergic reactions, Pediatr. Allergy Immunol., 29, 218, 10.1111/pai.12837 · DOI
  68. Zhong, 2018, Efficacy and safety of oral immunotherapy for peanut allergy: A pilot study in Singaporean children, Asia Pac. Allergy, 9, e1, 10.5415/apallergy.2019.9.e1 · DOI
  69. Fauquert, 2018, Peanut Gastro-Intestinal Delivery Oral Immunotherapy in Adolescents: Results of the build-up phase of a randomized, double-blind, placebo-controlled trial (PITA study), Clin. Exp. Allergy, 48, 862, 10.1111/cea.13148 · DOI
  70. Blumchen, 2019, Efficacy, Safety, and Quality of Life in a Multicenter, Randomized, Placebo-Controlled Trial of Low-Dose Peanut Oral Immunotherapy in Children with Peanut Allergy, J. Allergy Clin. Immunol. Pract., 7, 479, 10.1016/j.jaip.2018.10.048 · DOI
  71. Wasserman, 2019, Real-World Experience with Peanut Oral Immunotherapy: Lessons Learned From 270 Patients, J. Allergy Clin. Immunol. Pract., 7, 418, 10.1016/j.jaip.2018.05.023 · DOI
  72. Buchanan, 2007, Egg oral immunotherapy in nonanaphylactic children with egg allergy, J. Allergy Clin. Immunol., 119, 199, 10.1016/j.jaci.2006.09.016 · DOI
  73. Vickery, 2010, Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance, Ann. Allergy Asthma Immunol., 105, 444, 10.1016/j.anai.2010.09.030 · DOI
  74. Escudero, 2015, Early sustained unresponsiveness after short-course egg oral immunotherapy: A randomized controlled study in egg allergic children, Clin. Exp. Allergy, 45, 1833, 10.1111/cea.12604 · DOI
  75. Giavi, 2016, Oral immunotherapy with low allergenic hydrolyzed egg in egg allergic children, Allergy, 71, 1575, 10.1111/all.12905 · DOI
  76. Yanagida, 2016, Safety and Efficacy of Low-Dose Oral Immunotherapy for Hen’s Egg Allergy in Children, Int. Arch. Allergy Immunol., 171, 265, 10.1159/000454807 · DOI
  77. Escudero, 2017, Efficacy and safety of high-dose rush oral immunotherapy in persistent egg allergic children. A randomized clinical trial, Ann. Allergy Asthma Immunol., 118, 356, 10.1016/j.anai.2016.11.023 · DOI
  78. Akashi, 2017, Randomized controlled trial of oral immunotherapy for egg allergy in Japanese patients, Pediatr. Int., 59, 534, 10.1111/ped.13210 · DOI
  79. Maeta, 2018, Low-Dose Oral Immunotherapy Using Low-Egg-Allergen Cookies for Severe Egg-Allergic Children Reduces Allergy Severity and Affects Allergen-Specific Antibodies in Serum, Int. Arch. Allergy Immunol., 175, 70, 10.1159/000485891 · DOI
  80. Inoue, 2018, Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study, Allergol. Int., 67, 209, 10.1016/j.alit.2017.07.007 · DOI
  81. Bird, 2019, Baked egg oral immunotherapy desensitizes baked egg allergic children to lightly cooked egg, J. Allergy Clin. Immunol. Pract., 7, 667, 10.1016/j.jaip.2018.07.013 · DOI
  82. Zapatero, 2019, Egg OIT in clinical practice (SEICAP II): Maintenance patterns and desensitization state after normalizing the diet, Pediatr. Allergy Immunol., 30, 214, 10.1111/pai.13002 · DOI
  83. Elizur, 2019, Walnut oral immunotherapy for desensitisation of walnut and additional tree nut allergies (Nut CRACKER): A single-centre, prospective cohort study, Lancet Child Adolesc. Health., 3, 312, 10.1016/S2352-4642(19)30029-X · DOI
  84. Escudero, 2014, Oral immunotherapy in children with IgE-mediated wheat allergy: Outcome and molecular changes, J. Investig. Allergol. Clin. Immunol., 24, 240
  85. Sato, 2015, Wheat oral immunotherapy for wheat-induced anaphylaxis, J. Allergy Clin. Immunol., 136, 1131, 10.1016/j.jaci.2015.07.019 · DOI
  86. Okada, 2016, Better management of wheat allergy using a very low-dose food challenge: A retrospective study, Allergol. Int., 65, 82, 10.1016/j.alit.2015.07.011 · DOI
  87. Khayatzadeh, 2016, A Safe and Effective Method for Wheat Oral Immunotherapy, Iran. J. Allergy Asthma Immunol., 15, 525
  88. Rekabi, 2017, Evaluation of a new protocol for wheat desensitization in patients with wheat-induced anaphylaxis, Immunother., 9, 637, 10.2217/imt-2017-0011 · DOI
  89. Winterroth, 2014, Safety and feasibility of oral immunotherapy to multiple allergens for food allergy, Allergy Asthma Clin. Immunol., 10, 1, 10.1186/1710-1492-10-1 · DOI
  90. Nurmatov, 2017, Allergen immunotherapy for IgE-mediated food allergy: A systematic review and meta-analysis, Allergy, 72, 1133, 10.1111/all.13124 · DOI
  91. Alvaro, 2014, Baseline specific IgE levels are useful to predict safety of oral immunotherapy in egg-allergic children, Clin. Exp. Allergy, 44, 130, 10.1111/cea.12233 · DOI
  92. Tripodi, 2013, Specific oral tolerance induction with raw HE in children with very severe egg allergy: A randomized controlled trial, Pediatr. Allergy Immunol., 24, 66, 10.1111/j.1399-3038.2012.01349.x · DOI
  93. Leonard, 2015, Baked milk-and egg-containing diet in the management of milk and egg allergy, J. Allergy Clin. Immunol. Pract., 3, 13, 10.1016/j.jaip.2014.10.001 · DOI
  94. Kim, 2011, Dietary baked milk accelerates the resolution of cow’s milk allergy in children, J. Allergy Clin. Immunol., 128, 125, 10.1016/j.jaci.2011.04.036 · DOI
  95. Leonard, 2012, Dietary baked egg accelerates resolution of egg allergy in children, J. Allergy Clin. Immunol., 130, 473, 10.1016/j.jaci.2012.06.006 · DOI

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Metadata

Authors
Mori, F., Barni, S., Liccioli, G., & Novembre, E.
Venue
Medicina
Publisher
MDPI AG
Published
2019-10-13
Volume
55
Issue
10
Pages
684
ISSN
1648-9144
DOI
10.3390/medicina55100684
PMC
PMC6843277
Cited by
25
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: Oral Immunotherapy (OIT): A Personalized Medicine. https://app.cochat.ai/papers/10.3390/medicina55100684
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Mori, F., Barni, S., Liccioli, G., & Novembre, E. (2019). Oral Immunotherapy (OIT): A Personalized Medicine. Medicina. https://doi.org/10.3390/medicina55100684