Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

Bin Sayeed, Muhammad; Karim, Selim; Sharmin, Tasnuva; Morshed, Mohammed

doi:10.3390/medicines3040029

Cited by 156Phytochemical Studies and BioactivitiesNatural product bioactivities and synthesisMedicinal Plant Research

Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

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Bin Sayeed, Muhammad, Karim, Selim, Sharmin, Tasnuva, Morshed, Mohammed·2016·Medicines

DOI 10.3390/medicines3040029PMC PMC5456237

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Abstract

Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokinetics, therapeutic potentials, toxicity, drug delivery and finally, to suggest future research with BS, classical as well as on-line literature were studied. Classical literature includes classical books on ethnomedicine and phytochemistry, and the electronic search included Pubmed, SciFinder, Scopus, the Web of Science, Google Scholar, and others. BS could be obtained from different plants, but the total biosynthetic pathway, as well as its exact physiological and structural function in plants, have not been fully understood. Different pharmacological effects have been studied, but most of the mechanisms of action have not been studied in detail. Clinical trials with BS have shown beneficial effects in different diseases, but long-term study results are not available. These have contributed to its current status as an “orphan phytosterol”. Therefore, extensive research regarding its effect at cellular and molecular level in humans as well as addressing the claims made by commercial manufacturers such as the cholesterol lowering ability, immunological activity etc. are highly recommended.

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β-sitosterol shows numerous health benefits including antimicrobial, anti-pulmonary tuberculosis, antidiabetic, anticancer, immune modulation, anti-HIV, anti-arthritic, antipyretic, antihyperlipidemic, anti-atherosclerosis, and angiogenic influences.
“In addition, β-sitosterol shows numerous health benefits such as antimicrobial, anti-pulmonary tuberculosis, antidiabetic, anticancer, immune modulation and anti-HIV, anti-arthritic, antipyretic, antihyperlipidemic, anti-atherosclerosis, and angiogenic influences.”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [98]
β-sitosterol lowers inflammatory activity by inhibiting the STAT1 pathway, and activation of NF-kB translocation is mediated by tyrosine phosphatase SHP-1.
“β-sitosterol lowers inflammatory activity by inhibiting the STAT1 pathway, and the activation of NF-kB translocation is mediated by tyrosine phosphatase SHP-1.”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [98]
β-sitosterol is beneficial as a dietary supplement to reduce plasma cholesterol and exhibits antioxidant activities or stimulates antioxidant enzymes.
“It is beneficial as a dietary supplement to reduce plasma cholesterol and exhibits antioxidant activities or stimulates antioxidant enzymes [98].”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [98]

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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Medicinal Natural Products
Dewick, P. M. (2009) · Wiley eBooks · doi:10.1002/9780470742761 · Cited by 1,364 · see citing works
Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and health-promoting uses
Moreau, R. A., Whitaker, B. D., & Hicks, K. B. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00006-1 · Cited by 1,162 · see citing works
Medicinal Natural Products: A Biosynthetic Approach
Kite, G. C., & Dewick, P. M. (1998) · Kew Bulletin · doi:10.2307/4114524 · Cited by 738 · see citing works
Plant-based foods and prevention of cardiovascular disease: an overview
Hu, F. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.544s · Cited by 700 · see citing works
Phytosterols as Anticancer Dietary Components: Evidence and Mechanism of Action
Awad, A. B., & Fink, C. S. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2127 · Cited by 647 · see citing works
Medicinal Natural Products
Dewick, P. M. (2001) · Wiley eBooks · doi:10.1002/0470846275 · Cited by 544 · see citing works
EFFECTS OF CORTISONE ACETATE AND PITUITARY ACTH ON RHEUMATOID ARTHRITIS, RHEUMATIC FEVER AND CERTAIN OTHER CONDITIONS: A Study in Clinical Physiology
HENCH, P. S. (1950) · Archives of Internal Medicine · doi:10.1001/archinte.1950.00230100002001 · Cited by 501 · see citing works
Metabolism of β-sitosterol in man
Salen, G., AHRENS, E. H., & Grundy, S. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106315 · Cited by 499 · see citing works
Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia
Gupta, R., Sharma, A. K., DOBHAL, M. P., SHARMA, M. C., & GUPTA, R. S. (2010) · Journal of Diabetes · doi:10.1111/j.1753-0407.2010.00107.x · Cited by 329 · see citing works
Plant Stanol and Sterol Esters in the Control of Blood Cholesterol Levels: Mechanism and Safety Aspects
Plat, J., & Mensink, R. P. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.015 · Cited by 307 · see citing works
New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
Calpe‐Berdiel, L., Escolá‐Gil, J. C., & Blanco‐Vaca, F. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.06.026 · Cited by 293 · see citing works
Randomised, placebo-controlled, double-blind clinical trial of β-sitosterol in patients with benign prostatic hyperplasia
Berges, R. R., Windeler, J., Trampisch, H. J., Senge, T., & BCAMS GROUP (1995) · The Lancet · doi:10.1016/s0140-6736(95)91085-9 · Cited by 290 · see citing works
Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts
Ryan, E., Galvin, K., O'Connor, T. P., Maguire, A. R., & O’Brien, N. M. (2006) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480600768077 · Cited by 279 · see citing works
β-Sitosterol modulates antioxidant enzyme response in RAW 264.7 macrophages
Vivancos, M., & Moreno, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.025 · Cited by 276 · see citing works
The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years
Bouic, P. J. (2001) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200111000-00001 · Cited by 275 · see citing works
β‐Sitosterol exhibits anti‐inflammatory activity in human aortic endothelial cells
Loizou, S., Lekakis, I., Chrousos, G. P., & Moutsatsou, P. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900012 · Cited by 270 · see citing works
Isolation of Stigmasterol and ?-Sitosterol from the dichloromethane extract of Rubus suavissimus
Chaturvedula, V. S. P., & Prakash, I. (2012) · International Current Pharmaceutical Journal · doi:10.3329/icpj.v1i9.11613 · Cited by 264 · see citing works
Beta-sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: Implications for their use as an immunomodulatory vitamin combination
Bouic, P. J., ETSEBETH, S. M., Liebenberg, R. W., Albrecht, C., Pegel, K. H., & Jaarsveld, P. P. V. (1996) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(97)85551-8 · Cited by 261 · see citing works
Dietary β-sitosterol as an internal standard to correct for cholesterol losses in sterol balance studies
Grundy, S. M., AHRENS, E. H., & Salen, G. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43108-6 · Cited by 261 · see citing works
Phytosterols: physiologic and metabolic aspects related to cholesterol-lowering properties
Brufau, G., Canela, M. Á., & Rafecas, M. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.02.003 · Cited by 258 · see citing works
Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: Results of a nested case-control analysis of the Prospective Cardiovascular Münster (PROCAM) study
Assmann, G., Cullen, P., Erbey, J. R., Ramey, D. R., Kannenberg, F., & Schulte, H. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.04.001 · Cited by 254 · see citing works
Identification of a Receptor Mediating Absorption of Dietary Cholesterol in the Intestine
Hauser, H., Dyer, J. H., Nandy, A., Vega, M. A., Werder, M., Bieliauskaite, E., Weber, F. E., Compassi, S., Gemperli, A. C., Boffelli, D., et al. (1998) · Biochemistry · doi:10.1021/bi982404y · Cited by 249 · see citing works
Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7
Moreno, J. J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00465-9 · Cited by 234 · see citing works
Anti-Inflammatory and Antipyretic Activities of β-Sitosterol
Gupta, M., Nath, R., Srivastava, N., Shanker, K., Kishor, K., & Kp, B. (1980) · Planta Medica · doi:10.1055/s-2008-1074919 · Cited by 232 · see citing works
Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study
Baskar, A. A., Savarimuthu Ignacimuthu, S. J., Paulraj, G., & Numair, K. S. A. (2010) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-10-24 · Cited by 227 · see citing works
Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview
Mishra, G., Singh, P. N. D., Verma, R. K., et al. (2011) · Der pharmacia lettre · Cited by 224 · see citing works
Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation
Plat, J., Nichols, J. A., & Mensink, R. P. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500272-jlr200 · Cited by 220 · see citing works
β‐sitosterol activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells
von Holtz, R. L., Fink, C. S., & Awad, A. B. (1998) · Nutrition and Cancer · doi:10.1080/01635589809514709 · Cited by 216 · see citing works
Isolation and identification of mosquito larvicidal compound from Abutilon indicum (Linn.) Sweet
Rahuman, A. A., Gopalakrishnan, G., Venkatesan, P., et al. (2008) · Parasitology Research · doi:10.1007/s00436-007-0864-5 · Cited by 214 · see citing works
β-Sitosterol activates Fas signaling in human breast cancer cells
Awad, A. B., Chinnam, M., Fink, C. S., & Bradford, P. G. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.01.003 · Cited by 211 · see citing works
The degree of unsaturation of dietary fatty acids and the development of atherosclerosis (review)
Moreno, J. J., & Mitjavila, M. T. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00294-2 · Cited by 207 · see citing works
Beta-Sitosterol: A Promising but Orphan Nutraceutical to Fight Against Cancer
Sayeed, M. S. B., & Ameen, S. S. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1087042 · Cited by 195 · see citing works
Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis.
Salen, G., Shore, V. G., Tint, G. S., et al. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38259-6 · Cited by 193 · see citing works
A multicentric, placebo‐controlled, double‐blind clinical trial of β‐sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia
Klippel, K. F., Hiltl, D.-M., Schipp, B., & for the German BPH‐Phyto study group‡ (1997) · British Journal of Urology · doi:10.1046/j.1464-410x.1997.t01-1-00362.x · Cited by 182 · see citing works
No Association Between Plasma Levels of Plant Sterols and Atherosclerosis in Mice and Men
Wilund, K. R., Yu, L., Xu, F., Vega, G. L., Grundy, S. M., Cohen, J. C., & Hobbs, H. H. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149140.00499.92 · Cited by 182 · see citing works
Dietary -sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes
Miettinen, T. A., & Vanhanen, H. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90052-3 · Cited by 181 · see citing works
beta-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids.
Awad, A. B., Chen, Y. C., Fink, C. S., & Hennessey, T. M. (1996) · PubMed · Cited by 173 · see citing works
A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5- α -Reductase in the Treatment of Androgenetic Alopecia
Prager, N. A., Bickett, K., French, N., & Marcovici, G. (2002) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2002.8.143 · Cited by 172 · see citing works
Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer
Normén, A. L., Brants, H. A. M., VOORRIPS, L. E., et al. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.1.141 · Cited by 171 · see citing works
Bioactivity studies on β‐sitosterol and its glucoside
Villaseñor, I. M., Angelada, J. S., Canlas, A. P., & Echegoyen, D. E. (2002) · Phytotherapy Research · doi:10.1002/ptr.910 · Cited by 165 · see citing works
A ncovel angiogenic factor derived from Aloe vera gel: β-sitosterol, a plant sterol
Moon, E.-J., Lee, Y. M., Lee, O.-H., Lee, M.-J., Lee, S.-K., Chung, M.-H., Park, Y.-I., Sung, C.-K., Choi, J.-S., & Kim, K. (1999) · Angiogenesis · doi:10.1023/a:1009058232389 · Cited by 163 · see citing works
Anti-Inflammatory and Immunomodulating Properties of a Sterol Fraction from Sideritis foetens Clem.
NAVARRO, A., Heras, B. D. L., & Villar, Á. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.470 · Cited by 155 · see citing works
A Comparison of Hypocholesterolemic Activity of β-Sitosterol and β-Sitostanol in Rats
Sugano, M., Morioka, H., & Ikeda, I. (1977) · Journal of Nutrition · doi:10.1093/jn/107.11.2011 · Cited by 155 · see citing works
.BETA.-Sitosterol Induces Anti-proliferation and Apoptosis in Human Leukemic U937 Cells through Activation of Caspase-3 and Induction of Bax/Bcl-2 Ratio
Park, C., Moon, D., Rhu, C.-H., Choi, B. T., Lee, W. H., Kim, G., & Choi, Y. H. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1317 · Cited by 152 · see citing works
Plant sterols and sterolins: a review of their immune-modulating properties.
Bouic, P. J., & Lamprecht, J. H. (1999) · PubMed · Cited by 149 · see citing works
Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf.
Jayaprakasha, G. K., Mandadi, K. K., Poulose, S. M., et al. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.04.044 · Cited by 139 · see citing works
Phytosterols Reduce In Vitro Metastatic Ability of MDA-MB-231 Human Breast Cancer Cells
Awad, A. B., Williams, H., & Fink, C. S. (2001) · Nutrition and Cancer · doi:10.1207/s15327914nc402_12 · Cited by 138 · see citing works
Biosynthesis of β-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units
De‐Eknamkul, W., & Potduang, B. (2003) · Phytochemistry · doi:10.1016/s0031-9422(02)00555-1 · Cited by 136 · see citing works
Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles
Armstrong, M., & Carey, M. C. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38604-1 · Cited by 131 · see citing works
Some aspects of mechanism of inhibition of cholesterol absorption by β-sitosterol
Ikeda, I., & Sugano, M. (1983) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(83)90243-2 · Cited by 129 · see citing works
Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells.
Choi, Y. H., Kong, K. R., Kim, Y. A., Jung, K., Kil, J.-H., Rhee, S., & Park, K.-Y. (2003) · PubMed · Cited by 127 · see citing works
Niemann-Pick C1-Like 1 Overexpression Facilitates Ezetimibe-Sensitive Cholesterol and β-Sitosterol Uptake in CaCo-2 Cells
Yamanashi, Y., Takada, T., & Suzuki, H. I. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.114181 · Cited by 127 · see citing works
Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture.
Awad, A. B., Downie, A., & Fink, C. S. (2000) · International Journal of Molecular Medicine · doi:10.3892/ijmm.5.5.541 · Cited by 125 · see citing works
β-Sitosterol down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in J774A.1 murine macrophages
Valerio, M. S., & Awad, A. B. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.02.018 · Cited by 125 · see citing works
Controversial role of plant sterol esters in the management of hypercholesterolaemia
Weingärtner, O., Böhm, M., & Laufs, U. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn580 · Cited by 125 · see citing works
β-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells
Awad, A. B., Roy, R., & Fink, C. S. (2003) · Oncology Reports · doi:10.3892/or.10.2.497 · Cited by 124 · see citing works
The Effects of B-Sitosterol (BSS) and B-Sitosterol Glucoside (BSSG) Mixture on Selected Immune Parameters of Marathon Runners: Inhibition of Post Marathon Immune Suppression and Inflammation
Bouic, P. J., Clark, A. M., Lamprecht, J., Freestone, M., Pool, E. J., Liebenberg, R. W., Kotze, D., & van Jaarsveld, P. (1999) · International Journal of Sports Medicine · doi:10.1055/s-2007-971127 · Cited by 124 · see citing works
Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves
Nirmal, S. A., Pal, S. C., Mandal, S. C., et al. (2011) · Inflammopharmacology · doi:10.1007/s10787-011-0110-8 · Cited by 123 · see citing works
Dietary cholesterol, β-sitosterol, and stigmasterol
Nair, P. P., Turjman, N. A., Kessie, G., et al. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.4.927 · Cited by 123 · see citing works
beta-Sitosterol inhibits growth of HT-29 human colon cancer cells by activating the sphingomyelin cycle.
Awad, A. B., von Holtz, R. L., Cone, J. P., Fink, C. S., & Chen, Y. C. (1998) · PubMed · Cited by 121 · see citing works
Dietary intake of plant sterols stably increases plant sterol levels in the murine brain
Vanmierlo, T., Weingärtner, O., van der Pol, S. M. A., Husche, C., Kerksiek, A., Friedrichs, S., Sijbrands, E. J. G., Steinbusch, H. W. M., Grimm, M. O. W., Hartmann, T., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m017244 · Cited by 119 · see citing works
beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification
Field, F. J., & Mathur, S. N. (1983) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37981-5 · Cited by 119 · see citing works
Discrimination between cholesterol and sitosterol for absorption in rats.
Ikeda, I., Tanaka, K., Sugano, M., et al. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38409-1 · Cited by 117 · see citing works
The safety evaluation of phytosterol esters. Part 6. The comparative absorption and tissue distribution of phytosterols in the rat
Sanders, D. J., Minter, H., Howes, D., et al. (2000) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00021-1 · Cited by 116 · see citing works
Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol
Aringer, L., & Eneroth, P. H. E. (1974) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36787-0 · Cited by 116 · see citing works
Binding of permixon, a new treatment for prostatic benign hyperplasia, to the cytosolic androgen receptor in the rat prostate
Carilla, E., Briley, M., Fauran, F., et al. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90265-6 · Cited by 104 · see citing works
Liquid chromatography–UV determination and liquid chromatography–atmospheric pressure chemical ionization mass spectrometric characterization of sitosterol and stigmasterol in soybean oil
Careri, M., Elviri, L., & Mangia, A. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01079-2 · Cited by 103 · see citing works
Dietary plant sterols accumulate in the brain
Jansen, P. J., Lütjohann, D., Abildayeva, K., Vanmierlo, T., Plösch, T., Plat, J., von Bergmann, K., Groen, A. K., Ramaekers, F. C. S., Kuipers, F., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.03.015 · Cited by 103 · see citing works
Biological activity of Anthraquinones and Triterpenoids from Prismatomeris fragrans
Kanokmedhakul, K., Kanokmedhakul, S., & Phatchana, R. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.03.018 · Cited by 102 · see citing works
Viper and cobra venom neutralization by β-sitosterol and stigmasterol isolated from the root extract of Pluchea indica Less. (Asteraceae)
Gomes, A., Saha, A., Chatterjee, I., et al. (2007) · Phytomedicine · doi:10.1016/j.phymed.2006.12.020 · Cited by 100 · see citing works
Inhibition of sortase-mediated Staphylococcus aureus adhesion to fibronectin via fibronectin-binding protein by sortase inhibitors
Oh, K., Oh, M., Kim, J.-G., Shin, D., & Shin, J. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0040-8 · Cited by 98 · see citing works
Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography–mass spectrometry (GC–MS) with selective ion monitoring (SIM)
Ahmida, H. S. M. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.05.024 · Cited by 97 · see citing works
Comparison of the cytotoxic effects of β-sitosterol oxides and a cholesterol oxide, 7β-hydroxycholesterol, in cultured mammalian cells
Maguire, L., Анатольевич, К. М., Ford, A., Maguire, A. R., & O’Brien, N. M. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003956 · Cited by 97 · see citing works
Silymarin loaded liposomes for hepatic targeting: In vitro evaluation and HepG2 drug uptake
Elmowafy, M., Viitala, T., Ibrahim, H. M., et al. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.06.012 · Cited by 96 · see citing works
Punica granatum (Pomegranate) Juice Provides an HIV‐1 Entry Inhibitor and Candidate Topical Microbicide
NEURATH, A. R., Strick, N., Li, Y., & Debnath, A. K. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1352.015 · Cited by 96 · see citing works
β-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways
Moon, D., Kim, M.-O., Choi, Y. H., & Kim, G. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.01.032 · Cited by 96 · see citing works
Effect of resveratrol and β-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells
Awad, A. B., Burr, A. T., & Fink, C. S. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.11.005 · Cited by 95 · see citing works
Gram-scale chromatographic purification of β-sitosterolSynthesis and characterization of β-sitosterol oxides
ZHANG, X., Geoffroy, P. A., Miesch, M., et al. (2005) · Steroids · doi:10.1016/j.steroids.2005.06.003 · Cited by 93 · see citing works
Phytotherapy for benign prostatic hyperplasia
Wilt, T. J., Ishani, A., Rutks, I. R., & MacDonald, R. H. (2000) · Public Health Nutrition · doi:10.1017/s1368980000000549 · Cited by 93 · see citing works
Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion
Sudhop, T., Sahin, Y., Lindenthal, B., Hahn, C., Lüers, C., Berthold, H. K., & von Bergmann, K. (2002) · Gut · doi:10.1136/gut.51.6.860 · Cited by 92 · see citing works
Suppression of ovalbumin-induced Th2-driven airway inflammation by β-sitosterol in a guinea pig model of asthma
Mahajan, S. G., & Mehta, A. A. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.075 · Cited by 92 · see citing works
The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels
Mooradian, A. D., Haas, M. J., & Wong, N. C. W. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0013 · Cited by 91 · see citing works
Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis
Scheel‐Toellner, D., Wang, K., Assi, L. K., Webb, P. R., Craddock, R. M., Salmon, M., & Lord, J. M. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320679 · Cited by 91 · see citing works
Immunomodulatory properties of Beta-sitosterol in pig immune responses
Fraile, L. J., Crisci, E., Córdoba, L., Navarro, M. Á., Osada, J., & Montoya, M. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.04.017 · Cited by 91 · see citing works
Novel ultra-deformable vesicles entrapped with bleomycin and enhanced to penetrate rat skin
Hiruta, Y., Hattori, Y., Kawano, K., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.016 · Cited by 88 · see citing works
Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles
Zhou, Z., Li, L., Yang, Y., Xu, X., & Huang, Y. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.059 · Cited by 86 · see citing works
Antinociceptive Properties of Steroids Isolated from Phyllanthus corcovadensis in Mice
Santos, A. R. S., Niero, R., Filho, V. C., et al. (1995) · Planta Medica · doi:10.1055/s-2006-958093 · Cited by 86 · see citing works
Competitive inhibition of bile acid synthesis by endogenous cholestanol and sitosterol in sitosterolemia with xanthomatosis. Effect on cholesterol 7 alpha-hydroxylase.
Shefer, S., Salen, G., Nguyen, L. B., et al. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113799 · Cited by 85 · see citing works
Antihyperglycemic and insulin-releasing effects of beta-sitosterol 3-beta-D-glucoside and its aglycone, beta-sitosterol.
Ivorra, M. D., D’Ocón, P., Payá, M., & Villar, A. (1988) · PubMed · Cited by 84 · see citing works
β-Sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells
Moon, D., Lee, K., Choi, Y. H., et al. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.03.010 · Cited by 84 · see citing works
Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol
Brimson, J. M., Brimson, S. J., Brimson, C. A., Rakkhitawatthana, V., & Tencomnao, T. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13045074 · Cited by 83 · see citing works
Tribulosin and β-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris
Deepak, M., Dipankar, G., Prashanth, D., et al. (2002) · Phytomedicine · doi:10.1078/094471102321621395 · Cited by 82 · see citing works
Antimicrobial and cytotoxicity evaluation of Buchholzia coriacea stem bark
Ajaiyeoba, E. O., Onocha, P. A., Nwozo, S. O., et al. (2003) · Fitoterapia · doi:10.1016/s0367-326x(03)00142-4 · Cited by 82 · see citing works
Genotoxic and Cytotoxic Studies of Beta‐Sitosterol and Pteropodine in Mouse
Paniagua‐Pérez, R., Madrigal‐Bujaidar, E., Reyes‐Cadena, S., et al. (2005) · BioMed Research International · doi:10.1155/jbb.2005.242 · Cited by 80 · see citing works
Drug treatment of hyperlipidemia
Yeshurun, D., & Gotto, A. M. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90755-5 · Cited by 79 · see citing works
Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involvement of the GABA/benzodiazepine receptor complex
López‐Rubalcava, C., Piña-Medina, B., Estrada‐Reyes, R., et al. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.078 · Cited by 78 · see citing works
A novel method of producing a microcrystalline β-sitosterol suspension in oil
Christiansen, L., Rantanen, J., von Bonsdorff, A. K., et al. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(01)00223-8 · Cited by 77 · see citing works
Methodological considerations for the harmonization of non-cholesterol sterol bio-analysis
MacKay, D., Jones, P. J. H., Myrie, S. B., Plat, J., & Lütjohann, D. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.02.052 · Cited by 76 · see citing works
Effects of a phytosterol mixture on male fish plasma lipoprotein fractions and testis P450scc activity
Gilman, C. I., Leusch, F. D. L., Breckenridge, W. C., & MacLatchy, D. L. (2003) · General and Comparative Endocrinology · doi:10.1016/s0016-6480(02)00590-7 · Cited by 76 · see citing works
Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing compounds (EVNCs)
Kotwal, G. J. (2008) · Vaccine · doi:10.1016/j.vaccine.2007.12.008 · Cited by 75 · see citing works
Study of the Topical Anti-Inflammatory Activity of Achillea ageratum on Chronic and Acute Inflammation Models
Gómez, M. A., Sáenz, M. T., García, M. D., & Fernández, Á. (1999) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1999-1113 · Cited by 73 · see citing works
A Method for the Preparation of Submicron Particles of Sparingly Water-Soluble Drugs by Precipitation in Oil-in-Water Emulsions. II: Influence of the Emulsifier, the Solvent, and the Drug Substance
Sjöström, B., Bergenståhl, B., & Kronberg, B. (1993) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600820608 · Cited by 72 · see citing works
The in vitro Anti-Fungal and Anti-Bacterial Activities of β-Sitosterol from Senecio lyratus (Asteraceae)
Kiprono, P. C., Kaberia, F., Keriko, J. M., & Karanja, J. N. (2000) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2000-5-629 · Cited by 71 · see citing works
Nutrition Protocols for the Prevention of Cardiovascular Disease
Retelny, V. S., Neuendorf, A., & Roth, J. L. (2008) · Nutrition in Clinical Practice · doi:10.1177/0884533608323425 · Cited by 70 · see citing works
FLOW CYTOMETRIC ANALYSIS OF THE TH1–TH2 BALANCE IN HEALTHY INDIVIDUALS AND PATIENTS INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS (HIV) RECEIVING A PLANT STEROL/STEROLIN MIXTURE
Breytenbach, U., Clark, A., Lamprecht, J. H., et al. (2001) · Cell Biology International · doi:10.1006/cbir.2000.0676 · Cited by 69 · see citing works
Plant sterols: Friend or foe in CNS disorders?
Vanmierlo, T., Bogie, J., Mailleux, J., Vanmol, J., Lütjohann, D., Mulder, M., & Hendriks, J. J. A. (2015) · Progress in lipid research · doi:10.1016/j.plipres.2015.01.003 · Cited by 69 · see citing works
Comparison of various methods for the extraction of total lipids, fatty acids, cholesterol, and other sterols from food products
Hubbard, W. D., Sheppard, A. J., Newkirk, D. R., Prosser, A. R., & Osgood, T. (1977) · Journal of the American Oil Chemists Society · doi:10.1007/bf02912395 · Cited by 68 · see citing works
Identification and quantitative analysis of β-sitosterol oxides in vegetable oils by capillary gas chromatography–mass spectrometry
ZHANG, X., Julien-David, D., Miesch, M., GEOFFROY, P., Raul, F., Roussi, S., Werner, D., & Marchioni, E. (2005) · Steroids · doi:10.1016/j.steroids.2005.06.004 · Cited by 66 · see citing works
Determination of stigmasterol, β-sitosterol and stigmastanol in oral dosage forms using high performance liquid chromatography with evaporative light scattering detection
Nair, V. D. P., Kanfer, I., & Hoogmartens, J. (2006) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2005.12.030 · Cited by 66 · see citing works
Comparison of absorption and metabolism of β-sitosterol and β-sitostanol in rats
Ikeda, I., & Sugano, M. (1978) · Atherosclerosis · doi:10.1016/0021-9150(78)90049-7 · Cited by 66 · see citing works
Efficacy and Acceptability of Tadenan®(Pygeum africanum Extract) in the Treatment of Benign Prostatic Hyperplasia (BPH): A Multicentre Trial in Central Europe
Breza, J., Jr., Dzurný, O., Borówka, A., et al. (1998) · Current Medical Research and Opinion · doi:10.1185/03007999809113352 · Cited by 65 · see citing works
Rat toxicity studies with β-sitosterol
Malini, T., & Vanithakumari, G. (1990) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(90)90032-o · Cited by 65 · see citing works
Benign prostatic hyperplasia
Barry, M. J., & Roehrborn, C. (2001) · BMJ · doi:10.1136/bmj.323.7320.1042 · Cited by 65 · see citing works
Bioactivity-Guided isolation of β-Sitosterol and Some Fatty Acids as Active Compounds in the Anxiolytic and Sedative Effects of Tilia americana var. mexicana
Aguirre-Hernández, E., Rosas-Acevedo, H., Soto‐Hernández, M., et al. (2007) · Planta Medica · doi:10.1055/s-2007-981593 · Cited by 62 · see citing works
Plant sterols from foods in inflammation and risk of cardiovascular disease: A real threat?
Alemany, L., Barberá, R., Alegrı́a, A., & Laparra, J. M. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.03.038 · Cited by 61 · see citing works
In-vitro effects of polyphenols from cocoa and β-sitosterol on the growth of human prostate cancer and normal cells
Jourdain, C., Tenca, G., Deguercy, A., et al. (2006) · European Journal of Cancer Prevention · doi:10.1097/00008469-200608000-00009 · Cited by 60 · see citing works
Oxidation of Cholesterol and β-Sitosterol and Prevention by Natural Antioxidants
Xu, G., Guan, L., Sun, J., & Chen, Z. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902552s · Cited by 60 · see citing works
Incorporation of β-sitosterol into mitochondrial membrane enhances mitochondrial function by promoting inner mitochondrial membrane fluidity
Shi, C., Wu, F., & Xu, J. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9495-3 · Cited by 60 · see citing works
Pomegranate phytosterol (β-sitosterol) and polyphenolic antioxidant (punicalagin) addition to statin, significantly protected against macrophage foam cells formation
Rosenblat, M., Volkova, N., & Aviram, M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.10.054 · Cited by 60 · see citing works
Exposure to β-sitosterol alters the endocrine status of goldfish differently than 17β-estradiol
MacLatchy, D. L., Peters, L., Nickle, J., et al. (1997) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620160919 · Cited by 60 · see citing works
A randomised placebo-controlled trial of the efficacy of beta-sitosterol and its glucoside as adjuvants in the treatment of pulmonary tuberculosis.
Donald, P. R., Lamprecht, J. H., Freestone, M., et al. (1997) · PubMed · Cited by 60 · see citing works
Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol
Lacatusu, I., Badea, N. M., Stan, R., & Meghea, A. (2012) · Nanotechnology · doi:10.1088/0957-4484/23/45/455702 · Cited by 59 · see citing works
Side chain hydroxylation of cholesterol, campesterol and β-sitosterol in rat liver mitochondria
Aringer, L., Eneroth, P. H. E., & Nordström, L. (1976) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36983-2 · Cited by 59 · see citing works
Sitosterol reduces micellar cholesterol solubility in model bile
Jesch, E. D., & Carr, T. P. (2006) · Nutrition Research · doi:10.1016/j.nutres.2006.08.006 · Cited by 57 · see citing works
Synthesis, isolation and characterisation of β-sitosterol and β-sitosterol oxide derivatives
McCarthy, F. O., Chopra, J., Ford, A., Hogan, S. A., Kerry, J. P., O’Brien, N. M., Ryan, E., & Maguire, A. R. (2005) · Organic & Biomolecular Chemistry · doi:10.1039/b505069c · Cited by 56 · see citing works
Chemoprevention of Tumor Metastasis by Liposomal .BETA.-Sitosterol Intake
Imanaka, H., Koide, H., Shimizu, K., et al. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.400 · Cited by 56 · see citing works
The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP
Han, N., Kim, H., & Jeong, H. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213520111 · Cited by 56 · see citing works
7 α -Hydroxy- β -Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular Bax/Bcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK1/2 Activation
Tasyriq, M., Najmuldeen, I. A., In, L. L. A., Mohamad, K., Awang, K., & Hasima, N. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/765316 · Cited by 55 · see citing works
In vivo implants of β-sitosterol cause reductions of reactive cholesterol pools in mitochondria isolated from gonads of male goldfish (Carassius auratus)
Leusch, F. D. L., & MacLatchy, D. L. (2003) · General and Comparative Endocrinology · doi:10.1016/s0016-6480(03)00265-x · Cited by 54 · see citing works
Dietary Plant Sterols and Cholesterol Metabolism
Ellegård, L., Andersson, S. W., Normén, A. L., et al. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00266.x · Cited by 51 · see citing works
Clinical and molecular genetic analysis of a family with sitosterolemia and co-existing erythrocyte and platelet abnormalities.
Su, Y., Wang, Z., Yang, H., et al. (2006) · PubMed · Cited by 50 · see citing works
[Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism].
Breu, W., Hagenlocher, M., Redl, K., et al. (1992) · PubMed · Cited by 49 · see citing works
Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocystis carinii
Joffrion, T. M., & Cushion, M. T. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02007.x · Cited by 48 · see citing works
Induction of Bax and activation of caspases during β-sitosterol-mediated apoptosis in human colon cancer cells
Choi, Y. H., Kong, K. R., Kim, Y., Jung, K., Kil, J.-H., Rhee, S., & Park, K.-Y. (2003) · International Journal of Oncology · doi:10.3892/ijo.23.6.1657 · Cited by 46 · see citing works
Mechanisms of co-modified liver-targeting liposomes as gene delivery carriers based on cellular uptake and antigens inhibition effect
Zhang, Y., Qi, X., Gao, Y., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.11.006 · Cited by 44 · see citing works
Role of membrane microdomain rafts in TNFR-mediated signal transduction
Hueber, A. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401155 · Cited by 44 · see citing works
Antipyretic Activity of Peperomia pellucida Leaves in Rabbit
Khan, A., Rahman, M., & Islam, S. (2008) · DergiPark (Istanbul University) · Cited by 43 · see citing works
β-sitosterol inhibits high cholesterol-induced platelet β-amyloid release
Shi, C., Liu, J., Wu, F., et al. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9383-2 · Cited by 42 · see citing works
Absolute Oral Bioavailability and Metabolic Turnover of β-Sitosterol in Healthy Subjects
Duchateau, G. S. M. J. E., Cochrane, B. C., Windebank, S., et al. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.046623 · Cited by 42 · see citing works
The Effects of Pomegranate Seed Extract and β-Sitosterol on Rat Uterine Contractions
Promprom, W., Kupittayanant, P., Indrapichate, K., et al. (2009) · Reproductive Sciences · doi:10.1177/1933719109352687 · Cited by 42 · see citing works
Role of hydrophilic bile acids and of sterols on cholelithiasis in the hamster.
Singhal, A. K., Cohen, B. I., Finver‐Sadowsky, J., et al. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37769-5 · Cited by 41 · see citing works
Synthesis and Characterization of Stigmasterol Oxidation Products
Foley, D. A., O’Callaghan, Y. C., O’Brien, N. M., et al. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9024745 · Cited by 41 · see citing works
β-Sitosterol- d -glucopyranoside isolated from Desmostachya bipinnata mediates photoinduced rapid green synthesis of silver nanoparticles
Ahmed, K. B. A., Subramaniam, S., Veerappan, G., et al. (2014) · RSC Advances · doi:10.1039/c4ra10626a · Cited by 41 · see citing works
Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients
Thongtang, N., Lin, J., Schaefer, E. J., Lowe, R. S., Tomassini, J. E., Shah, A. K., & Tershakovec, A. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.09.001 · Cited by 41 · see citing works
Isolation of β-sitosterol and evaluation of antidiabetic activity of Aristolochia indica in alloxan-induced diabetic mice with a reference to in-vitro antioxidant activity
Karan, S. K. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr11.973 · Cited by 41 · see citing works
Serum plant sterols and lathosterol related to cholesterol absorption in coeliac disease
Vuoristo, M., Tilvis, R. S., & Miettinen, T. A. (1988) · Clinica Chimica Acta · doi:10.1016/0009-8981(88)90388-9 · Cited by 40 · see citing works
A potent sperm motility-inhibiting activity of bioflavonoids from an ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC, leaf extract
Chattopadhyay, D., Dungdung, S. R., Mandal, A. B., et al. (2005) · Contraception · doi:10.1016/j.contraception.2004.11.006 · Cited by 40 · see citing works
Effects of a New Soy/β-Sitosterol Supplement on Plasma Lipids in Moderately Hypercholesterolemic Subjects
Cicero, A. F. G., Fiorito, A., Panourgia, M. P., Sangiorgi, Z., & Gaddi, A. V. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90388-3 · Cited by 39 · see citing works
Gene regulation in β-sitosterol-mediated stimulation of adipogenesis, glucose uptake, and lipid mobilization in rat primary adipocytes
Chai, J.-W., Lim, S.-L., Kanthimathi, M. S., et al. (2010) · Genes & Nutrition · doi:10.1007/s12263-010-0196-4 · Cited by 39 · see citing works
Identification of metabolites of phytosterols in rat feces using GC/MS
Song, Y. S., Jin, C., & Park, E. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02975248 · Cited by 38 · see citing works
Beta‐sitosterolaemia: a new nonsense mutation in the ABCG5 gene
Mannucci, L., Guardamagna, O., Bertucci, P., et al. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01880.x · Cited by 37 · see citing works
Analysis of sterols by high‐performance liquid chromatography/mass spectrometry combined with chemometrics
Nagy, K., Jakab, A., Pollreisz, F., et al. (2006) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2606 · Cited by 37 · see citing works
Identification and characterization of β-sitosterol target proteins
Lomenick, B., Shi, H., Huang, J., & Chen, C. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.03.007 · Cited by 37 · see citing works
Unique Technology for Solubilization and Delivery of Highly Lipophilic Bioactive Molecules
Borowy‐Borowski, H., Sodja, C., Docherty, J. C., et al. (2004) · Journal of drug targeting · doi:10.1080/10611860412331285233 · Cited by 37 · see citing works
Drug Treatment of Hyperlipidemia
Wysenbeek, A. J., & Yeshurun, D. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-6-527_2 · Cited by 37 · see citing works
Fate of intravenously administered squalene and plant sterols in human subjects
Relas, H., Gylling, H., & Miettinen, T. A. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31623-0 · Cited by 36 · see citing works
Corn oil and its minor constituents as inhibitors of DMBA-induced chromosomal breaks in vivo
Raj, A. S., & Katz, M. (1984) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(84)90058-2 · Cited by 35 · see citing works
Acute effect of β-sitosterol on calcium uptake mediates anti-inflammatory effect in murine activated neutrophils
de Liz, R., Zanatta, L. C. B., dos Reis, G. O., et al. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01568.x · Cited by 35 · see citing works
Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J × CASA/Rk intercross
Sehayek, E., Duncan, E. M., Lütjohann, D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212640599 · Cited by 33 · see citing works
Alyssum homolocarpum seeds: phytochemical analysis and effects of the seed oil on neural stem cell proliferation and differentiation
Hamedi, A., Ghanbari, A., Razavipour, R., et al. (2015) · Journal of Natural Medicines · doi:10.1007/s11418-015-0905-9 · Cited by 32 · see citing works
Biosynthesis of β-sitosterol and stigmasterol proceeds exclusively via the mevalonate pathway in cell suspension cultures of Croton stellatopilosus
Kongduang, D., Wungsintaweekul, J., & De‐Eknamkul, W. (2008) · Tetrahedron Letters · doi:10.1016/j.tetlet.2008.04.049 · Cited by 32 · see citing works
Biocompatibility of chitosan/Mimosa tenuiflora scaffolds for tissue engineering
Martel-Estrada, S.-A., Rodríguez-Espinoza, B., Santos-Rodríguez, E., et al. (2015) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2015.01.034 · Cited by 32 · see citing works
Fecal β-Sitosterol in Patients with Diverticular Disease of the Colon and in Vegetarians
Miettinen, T. A., & Tarpila, S. (1978) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365527809181766 · Cited by 31 · see citing works
Understanding the side effects of glucocorticoid therapy: shining a light on a drug everyone thinks they know
Dixon, W. G., & Bansback, N. J. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202021 · Cited by 31 · see citing works
Antineoplastic activity of selected constituents of Duguetia glabriuscula
Matos, M. F. C., Leite, L., Brustolim, D., et al. (2006) · Fitoterapia · doi:10.1016/j.fitote.2006.01.013 · Cited by 30 · see citing works
Preparation of (25)- and (25)-26-functionalized steroids as tools for biosynthetic studies of cholic acids
Khripach, V. A., Zhabinskii, V. N., Konstantinova, O. V., et al. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.014 · Cited by 29 · see citing works
A concise synthesis of β-sitosterol and other phytosterols
Hang, J., & Dussault, P. H. (2010) · Steroids · doi:10.1016/j.steroids.2010.05.016 · Cited by 28 · see citing works
The Origin of Plant Sterols in the Skin Surface Lipids in Humans: From Diet to Plasma to Skin
Bhattacharyya, A. K., Connor, W. E., & Lin, D. S. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12534670 · Cited by 27 · see citing works
Liposome Vector Containing Biosurfactant-Complexed DNA as Herpes Simplex Virus Thymidine Kinase Gene Delivery System
Maitani, Y., Yano, S., Hattori, Y., et al. (2006) · Journal of Liposome Research · doi:10.1080/08982100600992443 · Cited by 27 · see citing works
Effects of β-sitosterol oral administration on the proliferation and differentiation of neural stem cells
Hamedi, A., Ghanbari, A., Saeidi, V., et al. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.03.021 · Cited by 26 · see citing works
Development and characterization of phyto-vesicles of β-sitosterol for the treatment of androgenetic alopecia
Upadhyay, K., Gupta, N. K., & Dixit, V. K. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1199-8 · Cited by 26 · see citing works
An Evidence-Based Systematic Review of Beta-Sitosterol, Sitosterol (22,23- dihydrostigmasterol, 24-ethylcholesterol) by the Natural Standard Research Collaboration
Ulbricht, C. E. (2015) · Journal of Dietary Supplements · doi:10.3109/19390211.2015.1008812 · Cited by 24 · see citing works
Further studies on membrane stabilizing, anti-inflammatory and FCA induced arthritic activity of various fractions of bark of Machilus macrantha in rats
Tatiya, A. U., & Saluja, A. K. (2011) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2011005000152 · Cited by 23 · see citing works
Oral Absorption Efficiency of Acid-Labile Antibiotics from Lipid-Drug Delivery Systems
Patel, S. P., & Jarowski, C. I. (1975) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600640535 · Cited by 22 · see citing works
Mechanisms of Lipid-Lowering Agents
Sirtori, C. R., Manzoni, C., & Lovati, M. R. (2008) · Cardiology · doi:10.1159/000174789 · Cited by 21 · see citing works
Multigenerational exposure to phytosterols in the mouse
Ryökkynen, A., KAYHKO, U., Mustonen, A.-M., et al. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2004.09.003 · Cited by 19 · see citing works
Treatment of severe hypercholesterolemia with a combination of beta-sitosterol and lovastatin
Richter, W. O., Geiss, H. C., Sönnichsen, A. C., & SCHWANDT, P. (1996) · Current Therapeutic Research · doi:10.1016/s0011-393x(96)80059-2 · Cited by 19 · see citing works
β-Sitosterol modulation of monocyte–endothelial cell interaction: A comparison to female hormones
Bustos, P., Duffau, C., Pacheco, C., & Natalia Ulloa, M. (2008) · Maturitas · doi:10.1016/j.maturitas.2008.06.002 · Cited by 19 · see citing works
[Beta-sitosterol in the treatment of hypercholesterolemia].
Žák, A., Zeman, M., Vítková, D., et al. (1990) · PubMed · Cited by 19 · see citing works
Antipyretic Activity of Azima tetracantha in Experimental Animals
Begum, T., Anand, A. V., & Senthil, R. D. (2010) · Research Journal of Pharmacognosy and Phytochemistry · Cited by 18 · see citing works
Sustained-Release Hormonal Preparations XV: Release of Progesterone from Cholesterol Pellets In Vivo
Joseph, A. A., Hill, J., Hill, J. L., et al. (1977) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600660408 · Cited by 18 · see citing works
In vitro anti-trypanosomal activity of Morinda lucida leaves
Nweze, N. E. (2012) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb11.862 · Cited by 18 · see citing works
The enhancing effect of soybean-derived sterylglucoside and β-sitosterol β-d-glucoside on nasal absorption in rabbits
Maitani, Y., Nakamura, K., Suenaga, H., et al. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00470-6 · Cited by 17 · see citing works
Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy
Hedman, M., Miettinen, T. A., Gylling, H., Ketomäki, A., & Antikainen, M. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.08.068 · Cited by 17 · see citing works
Increased reproductive success in the white American mink (Neovison vison) with chronic dietary β-sitosterol supplement
Nieminen, P., Pölönen, I., & Mustonen, A. (2010) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2010.01.008 · Cited by 16 · see citing works
[Chemical constituents from flos Sesamum indicum L].
Hu, Y., Ye, W., Yin, Z., et al. (2007) · PubMed · Cited by 15 · see citing works
Pharmacokinetics and bioavailability of beta-sitosterol in the beagle dog.
Ritschel, W. A., Kastner, U., Hussain, A. S., et al. (1990) · PubMed · Cited by 15 · see citing works
Blockage of hydroxyl group partially abolishes the cholesterol-lowering activity of β-sitosterol
Wang, X., Huang, W., Lei, L., et al. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.11.019 · Cited by 15 · see citing works
Regional Intestinal Absorption of FITC–Dextran 4,400 with Nanoparticles Based on β-Sitosterol β-D-Glucoside in Rats
Nakamura, K., Takayama, K., Nagai, T., & Maitani, Y. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10292 · Cited by 14 · see citing works
Evaluation of reproductive safety of β-sitosterol on the American mink (Neovison vison)
Nieminen, P., Pölönen, I., Ikonen, K., et al. (2007) · Chemosphere · doi:10.1016/j.chemosphere.2007.10.011 · Cited by 13 · see citing works
Synthesis of highly pure oxyphytosterols and (oxy)phytosterol estersPart I. Regioselective hydrogenation of stigmasterol: An easy access to oxyphytosterols
Geoffroy, P., Julien-David, D., Marchioni, E., et al. (2008) · Steroids · doi:10.1016/j.steroids.2008.02.004 · Cited by 12 · see citing works
Effect of Beta-sitosterol on cholesterol-cholic acid-induced gallstone formation in mice.
Sk, G., & Cf, F. (1976) · PubMed · Cited by 12 · see citing works
Quantitative determination of steroids in the fruiting bodies and submerged-cultured mycelia of Inonotus obliquus.
Gao, Y., Xu, H., Lu, Z., et al. (2009) · PubMed · Cited by 11 · see citing works
[Effects of beta-sitosterol on microtubular systems in cervical cancer cells].
Wang, L., Yang, Y., Chen, S.-H., et al. (2006) · PubMed · Cited by 11 · see citing works
Rapid purification of gram quantities of β-sitosterol from a commercial phytosterol mixture
Srividya, N., Heidorn, D. B., & Lange, B. M. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-182 · Cited by 9 · see citing works
Efeitos terapêuticos dos fitosteróis e fitostanóis na colesterolemia
Martins, S. L. C., Silva, H. F., Novaes, M. R. C. G., et al. (2004) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 8 · see citing works
CNS Active Principles fromAlangium plantanifolium
Zhu, M. (1998) · Planta Medica · doi:10.1055/s-2006-957356 · Cited by 8 · see citing works
Cholesterol metabolism in distance runners
Sutherland, W. H. F., Nye, E. R., Macfarlane, D. J., et al. (1992) · Clinical Physiology · doi:10.1111/j.1475-097x.1992.tb00291.x · Cited by 8 · see citing works
Effect of β-sitosterol concentration and high pressure homogenization on the chlorhexidine release from vesicular gels
FARKAS, E., Schubert, R., & Zelkó, R. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.09.018 · Cited by 8 · see citing works

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[106]Pollak O.J. Kritchevsky D. Sitosterol Karger Basel, Switzerland 1981

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Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds
Agarwal, A., Rizwana, Tripathi, A. D., Kumar, T., Sharma, K. P., & Patel, S. K. S. (2023) · Antioxidants · doi:10.3390/antiox12071413 · Cited by 135 · see citing works

Authors: Bin Sayeed, M., Karim, S., Sharmin, T., & Morshed, M.
Affiliations: Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh
Daffodil International University (BD)
University of Dhaka (BD)
ORCID: Bin Sayeed, Muhammad
Sharmin, Tasnuva
Morshed, Mohammed
Venue: Medicines
Publisher: MDPI AG
Published: 2016-11-15
Volume: 3
Issue: 4
Pages: 29
ISSN: 2305-6320 (ISSN-L)
DOI: 10.3390/medicines3040029
PMC: PMC5456237
OpenAlex: W2552642879
Cited by: 156
References: 205
Citations by year: 2026: 7 · 2025: 17 · 2024: 22 · 2023: 20 · 2022: 24 · 2021: 21 · 2020: 23 · 2019: 17 · 2018: 3 · 2017: 2
FWCI: 0.66
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Medicines (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Uppsala Universitet
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: β-sitosterol, phytosterols, sterol biosynthesis, pharmacokinetics, cholesterol lowering, immunological activity, toxicity, drug delivery, cell membrane stabilization, clinical trials, ethnomedicine

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Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

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