The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Approaches to Dispersing Medical Biofilms
Open accessAbstract
Biofilm-associated infections pose a complex problem to the medical community, in that residence within the protection of a biofilm affords pathogens greatly increased tolerances to antibiotics and antimicrobials, as well as protection from the host immune response. This results in highly recalcitrant, chronic infections and high rates of morbidity and mortality. Since as much as 80% of human bacterial infections are biofilm-associated, many researchers have begun investigating therapies that specifically target the biofilm architecture, thereby dispersing the microbial cells into their more vulnerable, planktonic mode of life. This review addresses the current state of research into medical biofilm dispersal. We focus on three major classes of dispersal agents: enzymes (including proteases, deoxyribonucleases, and glycoside hydrolases), antibiofilm peptides, and dispersal molecules (including dispersal signals, anti-matrix molecules, and sequestration molecules). Throughout our discussion, we provide detailed lists and summaries of some of the most prominent and extensively researched dispersal agents that have shown promise against the biofilms of clinically relevant pathogens, and we catalog which specific microorganisms they have been shown to be effective against. Lastly, we discuss some of the main hurdles to development of biofilm dispersal agents, and contemplate what needs to be done to overcome them.
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Citations
Cites
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
Kaplan, J. B. (2010) · Journal of Dental Research · doi:10.1177/0022034509359403 · Cited by 949
d -Amino Acids Trigger Biofilm Disassembly
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“Exoproteins are crucial for the ability of microbes to maintain and modify the EPS [13,14], and certain proteins, such as DNA-binding proteins (DNABPs), functional amyloids/amyloid-like proteins (FA/ALPs), and other biofilm-associated proteins (Baps), are vital contributors to surface and EPS scaffolding adhesion, and…”
BackgroundEnzymatic Detachment of Staphylococcus epidermidis Biofilms
Kaplan, J. B., Ragunath, C., Velliyagounder, K., Fine, D. H., & Ramasubbu, N. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2633-2636.2004 · Cited by 332
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Persister Cells: Molecular Mechanisms Related to Antibiotic Tolerance
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Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Fleitas Martínez, O., Cardoso, M. H., Ribeiro, S. M., & Franco, O. L. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00074 · Cited by 304
Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms
Saxena, P., Joshi, Y., Rawat, K., & Bisht, R. (2019) · Indian Journal of Microbiology · doi:10.1007/s12088-018-0757-6 · Cited by 216
Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms
Teirlinck, E., Xiong, R., Brans, T., Forier, K., Fraire, J., Van Acker, H., Matthijs, N., De Rycke, R., De Smedt, S. C., Coenye, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06884-w · Cited by 154
Metadata
- Authors
- Fleming, D., & Rumbaugh, K.
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2017-04-01
- Volume
- 5
- Issue
- 2
- Pages
- 15
- ISSN
- 2076-2607 (ISSN-L)
- OpenAlex
- W2604243962
- Cited by
- 329
- References
- 8
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
