Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms
Open accessAbstract
Hindered penetration of antibiotics through biofilms is one of the reasons for the alarming increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser-induced vapour nanobubbles (VNBs) formed around plasmonic nanoparticles to locally disturb biofilm integrity and improve antibiotics diffusion. Our results show that biofilms of both Gram-negative (Burkholderia multivorans, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria can be loaded with cationic 70-nm gold nanoparticles and that subsequent laser illumination results in VNB formation inside the biofilms. In all types of biofilms tested, VNB formation leads to substantial local biofilm disruption, increasing tobramycin efficacy up to 1-3 orders of magnitude depending on the organism and treatment conditions. Altogether, our results support the potential of laser-induced VNBs as a new approach to disrupt biofilms of a broad range of organisms, resulting in improved antibiotic diffusion and more effective biofilm eradication.
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Local disruption of the biofilms increased the permeability and therefore susceptibility to the antibiotic tobramycin.
“Local disruption of the biofilms increased the permeability and therefore susceptibility to the antibiotic tobramycin.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [81]
Laser irradiation of gold nanoparticles resulted in the formation of nanobubbles that disrupted the diffusional barrier of biofilms.
“Teirlinck et al. showed that laser irradiation of gold nanoparticles resulted in the formation of nanobubbles that disrupted this diffusional barrier 81 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [81]
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Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
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- Authors
- Teirlinck, E., Xiong, R., Brans, T., Forier, K., Fraire, J., Van Acker, H., Matthijs, N., De Rycke, R., De Smedt, S. C., Coenye, T., & Braeckmans, K.
- Affiliations
- Ghent University (BE)
- Ghent University Hospital (BE)
- Université de Lille (FR)
- Corresponding author
- Braeckmans, Kevin
- ORCID
- Venue
- Nature Communications
- Published
- 2018-10-30
- Volume
- 9
- Issue
- 1
- Pages
- 4518-4518
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6207769
- OpenAlex
- W2898384787
- Cited by
- 154
- References
- 76
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 22 · 2023: 19 · 2022: 22 · 2021: 29 · 2020: 25 · 2019: 14 · 2018: 1
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek (1500418N)
- Agentschap voor Innovatie door Wetenschap en Technologie (01G02215)
- EC | European Research Council (648124)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- bacterial biofilms, biofilm eradication, antibiotic penetration, tobramycin, plasmonic gold nanoparticles, photothermal therapy, Burkholderia multivorans, Pseudomonas aeruginosa, Staphylococcus aureus, antibiotic resistance
- MeSH terms
- Anti-Bacterial Agents, Diffusion, Gold, Lasers, Pseudomonas aeruginosa, Staphylococcus aureus, Tobramycin, Biofilms, Burkholderia, Metal Nanoparticles
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