The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review
Open accessAbstract
Dental caries remains the most prevalent and costly oral infectious disease worldwide. Several methods have been employed to prevent this biofilm-dependent disease, including the use of essential oils (EOs). In this systematic review, we discuss the antibacterial activity of EOs and their isolated constituents in view of a potential applicability in novel dental formulations. Seven databases were systematically searched for clinical trials, in situ, in vivo and in vitro studies addressing the topic published up to date. Most of the knowledge in the literature is based on in vitro studies assessing the effects of EOs on caries-related streptococci (mainly Streptococcus mutans) and lactobacilli, and on a limited number of clinical trials. The most promising species with antibacterial potential against cariogenic bacteria are: Achillea ligustica, Baccharis dracunculifolia, Croton cajucara, Cryptomeria japonica, Coriandrum sativum, Eugenia caryophyllata, Lippia sidoides, Ocimum americanum, and Rosmarinus officinalis. In some cases, the major phytochemical compounds determine the biological properties of EOs. Menthol and eugenol were considered outstanding compounds demonstrating an antibacterial potential. Only L. sidoides mouthwash (1%) has shown clinical antimicrobial effects against oral pathogens thus far. This review suggests avenues for further non-clinical and clinical studies with the most promising EOs and their isolated constituents bioprospected worldwide.
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1 retracted
Bilia, A. R., Guccione, C., Isacchi, B., Righeschi, C., Firenzuoli, F., & Bergonzi, M. C. (2014) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2014/651593 · Cited by 514
RetractedLiberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2015) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,533
Biological effects of essential oils—A review
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929
Role of Streptococcus mutans in human dental decay
Loesche, W. J. (1986) · Microbiological Reviews · doi:10.1128/mr.50.4.353-380.1986 · Cited by 6,171
Dong, Y., Hao, L., Shi, Z., Wang, G., Zhang, Z., & Han, C. (2013) · Urologia Internationalis · doi:10.1159/000351405 · Cited by 4,540
Role of Streptococcus mutans in human dental decay.
Loeshe, W. J. (1986) · Medical Entomology and Zoology · Cited by 1,346
Essential Oils in Combination and Their Antimicrobial Properties
Bassolé, I. H. N., & Juliani, H. R. (2012) · Molecules · doi:10.3390/molecules17043989 · Cited by 1,322
Cited by
Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems
Sharifi-Rad, J., Sureda, A., Tenore, G., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M., Ademiluyi, A., et al. (2017) · Molecules · doi:10.3390/molecules22010070 · Cited by 889
Extraction of High-Value Chemicals from Plants for Technical and Medical Applications
Kapadia, P., Newell, A. S., Cunningham, J., Roberts, M. R., & Hardy, J. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810334 · Cited by 111
Farag, M. A., Reda, A., Nabil, M., Elimam, D. M., & Zayed, A. (2023) · Food & Function · doi:10.1039/d3fo01949g · Cited by 28
Metadata
- Authors
- Freires, I., Denny, C., Benso, B., De Alencar, S., & Rosalen, P.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2015-04-22
- Volume
- 20
- Issue
- 4
- Pages
- 7329-7358
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W1997897577
- Cited by
- 301
- References
- 71
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- gold
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- Freires, I., Denny, C., Benso, B., De Alencar, S., & Rosalen, P. (2015). Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review. Molecules. https://doi.org/10.3390/molecules20047329
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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