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The Prodrug Approach: A Successful Tool for Improving Drug Solubility
Open accessAbstract
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.
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Cites
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Estrela, J. M., Ortega, A., & Obrador, E. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500523878 · Cited by 1,041
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A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems
Shahdadi Sardo, H., Saremnejad, F., Bagheri, S., Akhgari, A., Afrasiabi Garekani, H., & Sadeghi, F. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.01.022 · Cited by 126
Therapeutic targeting of senescent cells in the CNS
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Kim, A., Morato, N. M., Saha, P., Eyimegwu, P. N., Niyaz, A. A., Huang, R., Cooks, R. G., Phelan, R. M., & Lewis, J. C. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202503538 · Cited by 7
Metadata
- Authors
- Jornada, D., Dos Santos Fernandes, G., Chiba, D., De Melo, T., Dos Santos, J., & Chung, M.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2015-12-29
- Volume
- 21
- Issue
- 1
- Pages
- 42
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2213042592
- Cited by
- 294
- References
- 1
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jornada, D., Dos Santos Fernandes, G., Chiba, D., De Melo, T., Dos Santos, J., & Chung, M. (2015). The Prodrug Approach: A Successful Tool for Improving Drug Solubility. Molecules. https://doi.org/10.3390/molecules21010042
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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