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Therapeutic targeting of senescent cells in the CNS
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Senolytic therapy has progressed from a conceptual framework to a sophisticated field at the intersection of geroscience, immunotherapy, and chemical biology.
“Senolytic therapy has progressed from a conceptual framework to a sophisticated field at the intersection of geroscience, immunotherapy, and chemical biology139,140.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [139]
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Roy, A. L., Sierra, F., Howcroft, K., Singer, D. S., Sharpless, N., Hodes, R. J., Wilder, E. L., & Anderson, J. M. (2020) · Cell · doi:10.1016/j.cell.2020.10.032 · Cited by 81
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aguado, J., Amarilla, A. A., Taherian Fard, A., Albornoz, E. A., Tyshkovskiy, A., Schwabenland, M., Chaggar, H. K., Modhiran, N., Gómez-Inclán, C., Javed, I., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00519-6 · Cited by 80
Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
Bryant, A. G., Hu, M., Carlyle, B. C., Arnold, S. E., Frosch, M. P., Das, S., Hyman, B. T., & Bennett, R. E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.575953 · Cited by 79
Invariant natural killer T cells coordinate removal of senescent cells
Arora, S., Thompson, P. J., Wang, Y., Bhattacharyya, A., Apostolopoulou, H., Hatano, R., Naikawadi, R. P., Shah, A., Wolters, P. J., Koliwad, S., et al. (2021) · Med · doi:10.1016/j.medj.2021.04.014 · Cited by 77
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, D., Martins, I., Cristóvão, A. M., Dias, A. F., Neves-Silva, D., Pereira, T., Chapela, D., Farinho, A., Jacinto, A., & Saúde, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109334 · Cited by 74
Tominaga, T., Shimada, R., Okada, Y., Kawamata, T., & Kibayashi, K. (2019) · PLOS ONE · doi:10.1371/journal.pone.0213673 · Cited by 66
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Evolutionarily conserved regulators of tau identify targets for new therapies
Kim, J., de Haro, M., Al-Ramahi, I., Garaicoechea, L. L., Jeong, H.-H., Sonn, J. Y., Tadros, B., Liu, Z., Botas, J., & Zoghbi, H. Y. (2023) · Neuron · doi:10.1016/j.neuron.2022.12.012 · Cited by 50
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47
NIA workshop on senescence in brain aging and Alzheimer's disease and its related dementias
DiBattista, A. M., Sierra, F., & Masliah, E. (2020) · GeroScience · doi:10.1007/s11357-020-00153-9 · Cited by 16
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Garbarino, V. R., Palavicini, J. P., Melendez, J., Barthelemy, N. R., He, Y., Kautz, T. F., Lopez-Cruzan, M., Mathews, J. J., Xu, P., Zhang, B., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00591 · Cited by 26
“Reliable methodologies to identify senescent cells, assess their clearance, and evaluate related clinical ef fi cacy are essential for successfully translating senolytics from promising pre-clinical therapeutics to clinical applications [7][114].”
Self-citationNeural Stem Cell‐Derived Extracellular Vesicles for Advanced Neural Repair
Moretti, E. H., Lin, A. L. Y., Peruzzotti‐Jametti, L., Pluchino, S., & Mozafari, S. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70170 · Cited by 16
Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming
Zhang, W., Song, S., Zhang, Y., Pan, Y., Hu, D., & Wang, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00355-z · Cited by 6
Metadata
- Authors
- Riessland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2024-09-30
- Volume
- 23
- Issue
- 11
- Pages
- 817-837
- ISSN
- 1474-1776
- 1474-1784
- PMC
- PMC11927922
- Cited by
- 77
- References
- 97
- Language
- en
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