Nanotechnology Formulations for Antibacterial Free Fatty Acids and Monoglycerides
Open accessAbstract
Free fatty acids and monoglycerides have long been known to possess broad-spectrum antibacterial activity that is based on lytic behavior against bacterial cell membranes. Considering the growing challenges of drug-resistant bacteria and the need for new classes of antibiotics, the wide prevalence, affordable cost, and broad spectrum of fatty acids and monoglycerides make them attractive agents to develop for healthcare and biotechnology applications. The aim of this review is to provide a brief introduction to the history of antimicrobial lipids and their current status and challenges, and to present a detailed discussion of ongoing research efforts to develop nanotechnology formulations of fatty acids and monoglycerides that enable superior in vitro and in vivo performance. Examples of nano-emulsions, liposomes, solid lipid nanoparticles, and controlled release hydrogels are presented in order to highlight the potential that lies ahead for fatty acids and monoglycerides as next-generation antibacterial solutions. Possible application routes and future directions in research and development are also discussed.
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Lipids affect the gut microbiota both as substrates for bacterial metabolic processes and by inhibiting bacterial growth by toxic influence.
“Lipids affect the gut microbiota both as substrates for bacterial metabolic processes, and by inhibiting bacterial growth by toxic influence.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [14]
Fatty acids have a broad spectrum of antibacterial activity including lysis and solubilization of bacterial cell membranes and inhibition of ATP production.
“Fatty acids have a broad spectrum of antibacterial activity including lysis and solubilization of bacterial cell membranes [14, 15] and inhibition of ATP production [16].”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [14]
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References 91 · Cited by 109
Research works printed but not linked: 3
- [21]Thormar H. Antibacterial Effects of Lipids: Historical Review (1881 to 1960) Lipids and Essential Oils as Antimicrobial Agents John Wiley & Sons, Ltd Hoboken, NJ, USA 2011 25 45
- [35]Hammer K.A. Carson C.F. Antibacterial and Antifungal Activities of Essential Oils Lipids and Essential Oils as Antimicrobial Agents John Wiley & Sons, Ltd Hoboken, NJ, USA 2011 255 306
- [75]Kristmundsdóttir T. Árnadóttir S.G. Bergsson G. Thormar H. Development and evaluation of microbicidal hydrogels containing monoglyceride as the active ingredient J. Pharm. Sci. 1999 88 1011 1015 10.1021/js980378j 10514348 · DOI
- Authors
- Jackman, J., Yoon, B., Li, D., & Cho, N.-J.
- Affiliations
- Nanyang Technological University (SG)
- Corresponding author
- Cho, Nam-Joon
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2016-03-03
- Volume
- 21
- Issue
- 3
- Pages
- 305
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6273827
- OpenAlex
- W2289009712
- Cited by
- 109
- References
- 91
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 13 · 2023: 15 · 2022: 11 · 2021: 9 · 2020: 15 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 3
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by)
- Funders
- National Research Foundation (NRF-NRFF2011-01)
- A*STAR-NTU-NHG Skin Research Grant (SRG/14028)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- free fatty acids, monoglycerides, nanoemulsions, liposomes, solid lipid nanoparticles, bacterial membrane disruption, antibiotic resistance, drug delivery
- MeSH terms
- Anti-Bacterial Agents, Chemistry, Pharmaceutical, Drug Compounding, Emulsions, Fatty Acids, Nonesterified, Humans, Liposomes, Hydrogels, Nanotechnology, Nanostructures, Monoglycerides
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