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Cited by 538

The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.

Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review

Open access
Calixto, Giovana, Bernegossi, Jéssica, De Freitas, Laura, Fontana, Carla, Chorilli, Marlus·2016·Molecules

Abstract

Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer.

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Metadata

Authors
Calixto, G., Bernegossi, J., De Freitas, L., Fontana, C., & Chorilli, M.
Venue
Molecules
Publisher
MDPI AG
Published
2016-03-11
Volume
21
Issue
3
Pages
342
ISSN
1420-3049 (ISSN-L)
OpenAlex
W2293461885
Cited by
538
References
92
FWCI
34.43
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review. https://app.cochat.ai/papers/10.3390/molecules21030342
The paper
Calixto, G., Bernegossi, J., De Freitas, L., Fontana, C., & Chorilli, M. (2016). Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review. Molecules. https://doi.org/10.3390/molecules21030342

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.