Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

Songca, Sandile Phinda; Adjei, Yaw

doi:10.3390/ijms23063209

Cited by 177Photodynamic Therapy Research StudiesBacterial biofilms and quorum sensingAntimicrobial agents and applications

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

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Songca, Sandile Phinda, Adjei, Yaw·2022·International Journal of Molecular Sciences

DOI 10.3390/ijms23063209PMC PMC8953781

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Abstract

Antimicrobial photodynamic therapy and allied photodynamic antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic and biofilm forms. There has been little or no resistance development against antimicrobial photodynamic therapy. Furthermore, recent developments in therapies that involve antimicrobial photodynamic therapy in combination with photothermal hyperthermia therapy, magnetic hyperthermia therapy, antibiotic chemotherapy and cold atmospheric pressure plasma therapy have shown additive and synergistic enhancement of its efficacy. This paper reviews applications of antimicrobial photodynamic therapy and non-invasive combination therapies often used with it, including sonodynamic therapy and nanozyme enhanced photodynamic therapy. The antimicrobial and antibiofilm mechanisms are discussed. This review proposes that these technologies have a great potential to overcome the bacterial resistance associated with bacterial biofilm formation.

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PDT produces ROS that cause oxidative damage to targeted cells, including bacteria, fungi, parasites, viruses, and cancer cells, without significantly harming healthy tissues.
“This combination produces ROS, which can cause oxidative damage to targeted cells, including bacteria, fungi, parasites, viruses, and cancer cells, without significantly harming healthy tissues [134,135].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [135]
The Introduction lists PDT applications against viruses, bacteria, fungi, parasites, and cancer, while Section 3 explains that PDT-generated reactive oxygen species attack biomolecules and cause oxidative stress. The cited passages do not establish that these effects occur without significantly harming healthy tissues; the safety qualifier is unsupported. (LLM, conf=0.88)
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Antimicrobial Photodynamic Therapy with Chlorin e6 Is Bactericidal against Biofilms of the Primary Human Otopathogens
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Rapid and effective photodynamic treatment of biofilm infections using low doses of amoxicillin-coated gold nanoparticles
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In vitro antimicrobial photodynamic inactivation of multidrug-resistant Acinetobacter baumannii biofilm using Protoporphyrin IX and Methylene blue
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Influence of High Intensity Focused Ultrasound on the Microstructure and c-di-GMP Signaling of Pseudomonas aeruginosa Biofilms
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Combination of photodynamic therapy + immunotherapy + chemotherapy in murine leukiemia
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Novel phthalocyanines activated by dim light for mosquito larva- and cell-inactivation with inference for their potential as broad-spectrum photodynamic insecticides
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Comparison of the bactericidal effect of cold atmospheric pressure plasma (CAPP), antimicrobial photodynamic therapy (aPDT), and polihexanide (PHX) in a novel wet surface model to mimic oral cavity application
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Sae regulator factor impairs the response to photodynamic inactivation mediated by Toluidine blue in Staphylococcus aureus
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Effects of plasma jet, dielectric barrier discharge, photodynamic therapy and sodium hypochlorite on infected curved root canals
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Enhancement of cancerous cells treatment by applying cold atmospheric plasma and photo dynamic therapy simultaneously
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Treatment and Control of Leishmaniasis Using Photodynamic Therapy
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Two dimensional BP@AuNP nanocomposites for photothermal/photodynamic therapy mediated wound disinfection and infected wound healing under a single light source
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Influence of Photodynamic Therapy on Bacterial Attachment to Titanium Surface
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The ineffectiveness of antimicrobial photodynamic therapy in the absence of preincubation of the microorganisms in the photosensitizer
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[75]Aly F. Synergistic Antimicrobial Effects of Cold Atmospheric Pressure Plasma and Photodynamic Therapy against Common Skin and Wound Pathogens In-Vitro Ph.D. Thesis Universität Greifswald Greifswald, Germany 2021 Available online: https://epub.ub.uni-greifswald.de/frontdoor/index/index/docId/5680 (accessed on 16 January 2022)

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Authors: Songca, S. P., & Adjei, Y.
Affiliations: University of KwaZulu-Natal (ZA)
Council for Scientific and Industrial Research (GH)
Corresponding author: Songca, Sandile Phinda
ORCID: Songca, Sandile Phinda
Adjei, Yaw
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2022-03-16
Volume: 23
Issue: 6
Pages: 3209
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms23063209
PMC: PMC8953781
OpenAlex: W4220797560
Cited by: 175
References: 167
Citations by year: 2026: 39 · 2025: 50 · 2024: 48 · 2023: 29 · 2022: 9
FWCI: 5.93
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Research Foundation (118774 and 129391)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
Keywords: antimicrobial photodynamic therapy, bacterial biofilms, sonodynamic therapy, photothermal hyperthermia, magnetic hyperthermia, cold atmospheric plasma, combination antibiotic therapy, antimicrobial resistance
MeSH terms: Anti-Infective Agents, Anti-Bacterial Agents, Bacteria, Photochemotherapy, Photosensitizing Agents, Biofilms

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