Biologic stress, oxidative stress, and resistance to drugs: what is hidden behind
Open accessAbstract
Stress can be defined as the homeostatic, nonspecific defensive response of the organism to challenges. It is expressed by morphological, biochemical, and functional changes. In this review, we present biological and oxidative stress, as well as their interrelation. In addition to the mediation in biologic stress (central nervous, immune, and hormonal systems) and oxidative stress, the effect of these phenomena on xenobiotic metabolism and drug response is also examined. It is concluded that stress decreases drug response, a result which seems to be mainly attributed to the induction of hepatic drug metabolizing enzymes. A number of mechanisms are presented. Structure-activity studies are also discussed. Vitamin E, as well as two synthetic novel compounds, seem to reduce both oxidative and biological stress and, consequently, influence drug response and metabolism.
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Stress impacts host xenobiotic metabolism, particularly via induction of hepatic drug-metabolizing enzymes possibly mediated by glucocorticoids or noradrenaline.
“Stress is known to impact on host xenobiotic metabolism, particularly via induction of hepatic drug-metabolizing enzymes possibly mediated by glucocorticoids or noradrenaline (Konstandi, 2013;Pantelidou et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Pantelidou et al., 2017
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Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319 · see citing works
- Authors
- Pantelidou, M., Tsiakitzis, K., Rekka, E., & Kourounakis, P.
- Affiliations
- Frederick University (CY)
- Aristotle University of Thessaloniki (GR)
- Corresponding author
- Kourounakis, Panos
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2017-02-17
- Volume
- 22
- Issue
- 2
- Pages
- 307
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6155817
- OpenAlex
- W2588598801
- Cited by
- 7
- References
- 54
- Citations by year
- 2026: 1 · 2019: 3 · 2018: 2 · 2017: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- biological stress, oxidative stress, drug resistance, xenobiotic metabolism, hepatic drug-metabolizing enzymes, enzyme induction, structure-activity relationship, vitamin E, central nervous system, immune system, hormonal system, drug response
- MeSH terms
- Animals, Antioxidants, Drug Resistance, Humans, Organ Specificity, Oxidation-Reduction, Steroids, Stress, Physiological, Structure-Activity Relationship, Xenobiotics, Oxidants, Oxidative Stress
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