CoChat
Sign Up
Cited by 33

The DOI matches its Crossref record.

Genus Periploca (Apocynaceae): A Review of Its Classification, Phytochemistry, Biological Activities and Toxicology

Huang, Mingjin, Shen, Shoumao, Luo, Chunli, Ren, Yan·2019·Molecules
DOI 10.3390/molecules24152749PMC PMC6696197
Open this paper in CoChat — free account

Abstract

The genus Periploca belongs to the family Apocynaceae, which is composed of approximately ten species of plants according to incomplete statistics. Most of these plants serve as folk medicines with a long history, especially Periploca sepium and Periploca forrestii. The botanical classifications, chemical constituents, biological activities and toxicities of the genus Periploca were summarized in the literature from 1897 to early 2019. Though the botanical classification of this genus is controversial, these species are well-known to be rich sources of diverse and complex natural products—above all, cardiac steroids and C21 pregnane steroids with special structures and obvious pharmacological activities. The various crude extracts and 314 isolated metabolites from this genus have attracted much attention in intensive biological studies, indicating that they are equipped with cardiotonic, anti-inflammatory, immunosuppressive, antitumor, antimicrobial, antioxidant, insecticidal and other properties. It is noteworthy that some cardiac glycosides showed hepatotoxicity and cardiotoxicity at certain doses. Therefore, in view of the medical and agricultural value of the genus Periploca, in-depth investigations of the pharmacology in vivo, the mechanisms of biological actions, and the pharmacokinetics of the active ingredients should be carried out in the future. Moreover, in order to ensure the safety of clinical medication, the potential toxicities of cardiac glycosides or other compounds should also be paid attention. This systematic review provides an important reference base for applied research on pharmaceuticals and pesticides from this genus.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/molecules24152749

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 209

  1. Flora of China Editorial Committee (1995). Flora of China, Missouri Botanical Garden Press.
  2. National Pharmacopoeia Commission (2015). Pharmacopoeia of the People’s Republic of China, Beijing Chemical Industry Press.
  3. Editorial Board of Chinese Materia Medica, State Administration of Traditional Chinese Medicine (2005). Miao Medicine Volume of Chinese Materia Medica, Guizhou science and technology press.
  4. Zhang, 2003, Recent adcances of chemical constituents of Periploca plants, Nat. Prod. Res. Dev., 15, 157
  5. Luo, 2006, Advances of research of Periploca Plants, J. Dali Univ., 5, 54
  6. Venter, 1997, A revision of Periploca (Periplocaceae), S. Afr. J. Bot., 63, 123, 10.1016/S0254-6299(15)30723-7 · DOI
  7. Zhang, 2006, Studies on chemical constituents of Periploca omeiensis, Nat. Prod. Res. Dev., 18, 772
  8. Yao, 2002, A new species of Periploca from Gansu province, Bull. Bot. Res., 22, 259
  9. Azza, 2015, A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl4-induced injury on human hepatoma cell line (Huh7), Nat. Prod. Res., 29, 423, 10.1080/14786419.2014.950960 · DOI
  10. Lehmann, 1897, Active principles contained in the bark of periploca graeca, Arch. Der. Pharm., 235, 157, 10.1002/ardp.18972350113 · DOI
  11. Tan, 2010, Study on chemical constituents of Periploca calophylla, China Pharm. (ChongqingChina), 21, 4463
  12. Zhang, 2006, Chemical constituents from Periploca forestti, Chin. Tradit. Herb. Drugs, 37, 345
  13. Sakuma, 1969, On the structure of glycoside G and K of Bei-Wujiapi, Chem. Pharm. Bull. (Tokyo), 17, 2183, 10.1248/cpb.17.2183 · DOI
  14. Spera, 2007, Antiproliferative cardenolides from Periploca graeca, Planta Med., 73, 384, 10.1055/s-2007-967133 · DOI
  15. Shoji, 1967, Studies on the chemical constituents of Chinese drug Wujiapi, Chem. Pharm. Bull. (Tokyo), 15, 720, 10.1248/cpb.15.720 · DOI
  16. Stoll, 1939, Cardiac glucosides. XV. Periplocin, the true cardiac glucoside of Periploca graeca, Helv. Chim. Acta, 22, 1193, 10.1002/hlca.193902201153 · DOI
  17. Deng, 2010, A new cardenolide and two new pregnane glycosides from the root barks of Periploca sepium, Helv. Chim. Acta, 93, 1602, 10.1002/hlca.200900320 · DOI
  18. Li, 2012, Cytotoxic cardenolides from the stems of Periploca forrestii, Steroids, 77, 375, 10.1016/j.steroids.2011.12.013 · DOI
  19. Li, 2010, Identification of cardiac glycosides in fractions from Periploca forrestii by high-performance liquid chromatography/diode-array detection/electrospray ionization multi-stage tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 878, 381, 10.1016/j.jchromb.2009.12.008 · DOI
  20. Hu, 1989, The chemical constituents of Periploca forrestii, Acta Bot. Yunnanica, 11, 465
  21. Zhang, 2006, Two novel cardiac glycosides from Periploca forestti, Chin. J. Org. Chem., 26, 329
  22. Xu, 1990, Pregnanes and cardenolides from Periploca sepium, Phytochemistry, 29, 344, 10.1016/0031-9422(90)89071-G · DOI
  23. Schenker, 1954, Glycosides and aglycons. CXXXIV. The glycosides of Periploca nigrescens Afzel, Helv. Chim. Acta, 37, 1004, 10.1002/hlca.19540370408 · DOI
  24. Berthold, 1965, Die cardenolide von Parquetina nigrescens (Afzel) Bullock, Helv. Chim. Acta, 48, 1634, 10.1002/hlca.19650480725 · DOI
  25. Mauli, 1957, Glycosides and aglycons. CLXXI. The glycosides of Periploca nigrescens, Helv. Chim. Acta, 40, 299, 10.1002/hlca.19570400208 · DOI
  26. Berthold, 1965, Die cardenolide von Parquetina nigrescens (Afzel) Bullock) 3. Mitt.) Die konstitution 5 neuer cardenolide (16-Dehydrostrophanthidin und verwandte substanzen), Helv. Chim. Acta, 48, 1659, 10.1002/hlca.19650480726 · DOI
  27. Hu, 1990, New cardenolides of Periploca forrestii, Acta Chim. Sin. (Chin. Ed.), 43, 714
  28. Feng, 2009, Complete 1H and 13C NMR assignments of four new oligosaccharides and two new glycosides from Periploca forrestii, Magn. Reson. Chem., 47, 701, 10.1002/mrc.2440 · DOI
  29. Xu, 2012, A new cardiac glycoside from Periploca forrestii, China J. Chin. Mater. Med., 37, 2286
  30. Itokawa, 1988, Studies on chemical constituents of antitumor fraction from Periploca sepium. IV. Structures of new pregnane glycosides, Periplocosides D, E, L and M, Chem. Pharm. Bull. (Tokyo), 36, 2084, 10.1248/cpb.36.2084 · DOI
  31. Oshima, 1987, Periplosides A, B and C, steroidal glycosides of Periploca sepium root barks, Heterocycles, 26, 2093, 10.3987/R-1987-08-2093 · DOI
  32. Feng, 2008, Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii, Phytochemistry, 69, 2716, 10.1016/j.phytochem.2008.08.015 · DOI
  33. Wang, 2011, Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca, Phytochemistry, 72, 2230, 10.1016/j.phytochem.2011.07.018 · DOI
  34. Wang, 2013, Corrigendum to “Structural revision of periplocosides and periperoxides, natural immunosuppressive agents from the genus Periploca” [Phytochemistry 72/17 (2011) 2230-2236], Phytochemistry, 95, 445, 10.1016/j.phytochem.2013.07.028 · DOI
  35. Itokawa, 1988, Studies on chemical constituents of antitumor fraction from Periploca sepium. II. Structures of new pregnane glycosides, Periplocosides A, B and C, Chem. Pharm. Bull. (Tokyo), 36, 982, 10.1248/cpb.36.982 · DOI
  36. Itokawa, 1988, Studies on chemical constituents of antitumor fraction from Periploca sepium. V. Structures of new pregnane glycosides, Periplocosides J, K, F and O, Chem. Pharm. Bull. (Tokyo), 36, 4441, 10.1248/cpb.36.4441 · DOI
  37. Wang, 2017, Absolute configuration of Periplosides C and F and isolation of minor spiro-orthoester group-containing pregnane-type steroidal glycosides from Periploca sepium and their T-Lymphocyte proliferation inhibitory activities, J. Nat. Prod., 80, 1102, 10.1021/acs.jnatprod.7b00017 · DOI
  38. Qin, 2018, Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes, Bioorg. Med. Chem. Lett., 28, 330, 10.1016/j.bmcl.2017.12.045 · DOI
  39. Wang, 2011, Five new C21 steroidal glycosides from Periploca sepium, Steroids, 76, 238, 10.1016/j.steroids.2010.11.004 · DOI
  40. Itokawa, 1987, Studies on chemical constituents of antitumor fraction from Periploca sepium Bge. I, Chem. Pharm. Bull. (Tokyo), 35, 4524, 10.1248/cpb.35.4524 · DOI
  41. Zhang, 2016, Chemical Constituents from Periploca forrestii, J. Chin. Med. Mater., 39, 329
  42. Gu, 2017, C21 steroidal glycosides and oligosaccharides from the root bark of Periploca sepium, Fitoterapia, 118, 6, 10.1016/j.fitote.2017.02.005 · DOI
  43. Wang, 2007, A new pregnane and a new diphenylmethane from the root barks of Periploca sepium, Helv. Chim. Acta, 8, 1581, 10.1002/hlca.200790165 · DOI
  44. Zhang, 2011, Chemical constituents from Periploca forestti, Chin. Tradit. Herb. Drugs, 42, 1909
  45. Li, 2012, Chemical constituents from the roots of Periploca sepium with insecticidal activity, J. Asian Nat. Prod. Res., 14, 811, 10.1080/10286020.2012.691880 · DOI
  46. Shi, 2014, A new pregnane glycoside from the root barks of Periploca sepium, Chem. Nat. Compd., 49, 1043, 10.1007/s10600-014-0819-x · DOI
  47. Feng, 2014, Fluorescence localization and comparative ultrastructural study of periplocoside NW from Periploca sepium Bunge in the midgut of the oriental amyworm, Mythimna separata Walker (Lepidoptera: Noctuidae), Toxins, 6, 1575, 10.3390/toxins6051575 · DOI
  48. Itokawa, 1988, Pregnane glycosides from an antitumour fraction of Periploca sepium, Phytochemistry, 27, 1173, 10.1016/0031-9422(88)80297-8 · DOI
  49. Siciliano, 2005, Sulfated pregnane glycosides from Periploca graeca, J. Nat. Prod., 68, 1164, 10.1021/np050031d · DOI
  50. Umehara, 1995, Studies on differentiation inducers. V. Steroid glycosides from Periplocae Radicis Cortex, Chem. Pharm. Bull. (Tokyo), 43, 1565, 10.1248/cpb.43.1565 · DOI
  51. Yin, 2009, Steroids from the roots of Periploca sepium, Chin. Pharm. J. (BeijingChina), 44, 968
  52. Sakuma, 1980, Constituents of the Chinese crude drug “Wujiapi.” IX. Structure of glycoside H2, a patentiator of NGF-mediated nerve fiber outgrowth, Chem. Pharm. Bull. (Tokyo), 28, 163, 10.1248/cpb.28.163 · DOI
  53. Srivastava, 1982, Structure of calocin, J. Nat. Prod., 45, 211, 10.1021/np50020a018 · DOI
  54. Deepak, 1985, A pregnane ester glycoside from Periploca calophylla, Phytochemistry, 24, 1037, 10.1016/S0031-9422(00)83178-7 · DOI
  55. Deepak, 1986, A pregnane ester diglycoside from Periploca calophylla, Indian J. Chem. B, 25B, 44
  56. Sethi, 1988, A novel pregnane glycoside from Periploca calophylla, J. Nat. Prod., 51, 787, 10.1021/np50058a025 · DOI
  57. Feng, 2008, Five new pregnane glycosides from the root barks of Periploca sepium, Helv. Chim. Acta, 91, 1798, 10.1002/hlca.200890192 · DOI
  58. Khare, 2008, Absolute configuration of calogenin and its 20-keto derivative, Indian J. Chem. B, 47B, 1744
  59. Deepak, 1985, A pregnane ester diglycoside from Periploca calophylla, Phytochemistry, 24, 3015, 10.1016/0031-9422(85)80047-9 · DOI
  60. Liu, 2015, A new C21 steroidal saponins from Periplocae Cortex, China J. Chin. Mater. Med., 40, 455
  61. Sakuma, 1968, Constituents of Chinese crude drug “Wujiapi.” I. Studies on the aglycones of steroidal glycosides of Bei-Wujiapi, Chem. Pharm. Bull. (Tokyo), 16, 326, 10.1248/cpb.16.326 · DOI
  62. Sun, 2017, Melanogenesis-inhibitory and antioxidant activities of phenolics from Periploca forrestii, Chem. Biodivers., 14, e1700083, 10.1002/cbdv.201700083 · DOI
  63. Guo, 2003, Study on the chemical constituents of Periploca calophylla, Chin. Pharm. J. (BeijingChina), 38, 497
  64. Askri, 1989, Medicinal plants of Tunisia. The structure of Periplocadiol, a new elenmane-type sesquiterpene isolated from the roots of Periploca Laevigata, J. Nat. Prod., 52, 792, 10.1021/np50064a021 · DOI
  65. Xu, 2011, Study on chemical constituents of Periploca forrestii Schlecht, Chin. Pharm. J. (BeijingChina), 46, 823
  66. Mustafa, 2000, Lupene-type triterpenes from Periploca aphylla, J. Nat. Prod., 63, 881, 10.1021/np990426v · DOI
  67. Teresa, 2011, Triterpenoids from the stem bark of Periploca linearifolia (Asclepiadaceae), J. Kenya Chem. Soc., 6, 1
  68. Hichri, 2002, Triterpenoids from the fruit bark of Periploca laevigata growing in Tunisia, J. Soc. Chim. Tunis., 4, 1565
  69. Mitsuhashi, 1971, Components of Periploca aphylla. Constituents of Asclepiadaceae plants, Shoyakugaku Zasshi, 25, 7
  70. Guo, 2005, Study on the chemical constituents of Periploca calophylla (II), Chin. Tradit. Herb. Drugs, 36, 350
  71. Rehman, 2003, Phytochemical studies on Periploca aphylla, J. Chem. Soc. Pak., 25, 257
  72. Li, 2013, Chemical constituents of Periploca forrestii, China J. Chin. Mater. Med., 38, 1536
  73. Zhao, 2017, Chemical constituents from Periploca Radix, Chin. Tradit. Herb. Drugs, 48, 1513
  74. Ishizone, 1972, Constituents of Chinese crude drug “Wujiapi.” VII. On the structure of glycoside E of Bei-Wujiapi, Chem. Pharm. Bull. (Tokyo), 20, 2402, 10.1248/cpb.20.2402 · DOI
  75. Kawanishi, 1972, Constituents of Chinese crude drug “Wujiapi.” V. On the structure of glycoside H1 of Bei-Wujiapi, Chem. Pharm. Bull. (Tokyo), 20, 469, 10.1248/cpb.20.469 · DOI
  76. Tan, 2003, Chemical constituents from the roots of Biondia Hemsleyana, Chem. J. Chin. Univ., 24, 436
  77. Kawanishi, 1977, Constituents of Chinese crude drug “Wujiapi.” VIII. On the structures of new oligosaccharides C1, D2, F1, and F2 of Bei-Wujiapi, Chem. Pharm. Bull. (Tokyo), 25, 2055, 10.1248/cpb.25.2055 · DOI
  78. Wang, 2010, Perisesaccharides A-E, new oligosaccharides from the root barks of Periploca sepium, Planta Med., 76, 909, 10.1055/s-0029-1240842 · DOI
  79. Bi, 2011, Chemical constituents in the root barks of Periploca sepium, Pharm. Clin. Res., 19, 521
  80. Long, 2012, A new oligosaccharide from Periploca calophylla, China J. Chin. Mater. Med., 37, 226
  81. Yu, 2005, A study on chemical constituents of the stem of Periploca sepium, J. Northwest. Univ., 20, 145
  82. Kawanishi, 1972, Constituents of Chinese crude drug “Wujiapi.” IV. On the structure of a new acetylbiose from steroidal glycosides of Bei-Wujiapi, Chem. Pharm. Bull. (Tokyo), 20, 93, 10.1248/cpb.20.93 · DOI
  83. Malik, 2004, Lipoxygenase inhibitory constituents from Periploca aphylla, J. Nat. Prod., 67, 1450, 10.1021/np030494o · DOI
  84. Gang, 2009, Chemical constituents of Periploca forrestii Schltr, Chin. Tradit. Herb. Drugs, 40, 708
  85. Ma, 2010, Chemical composition of the Periploca sepium, Chem. Nat. Compd., 46, 464, 10.1007/s10600-010-9646-x · DOI
  86. Besbes, 2017, Isolation and structure elucidation of acetylcholinesterase lipophilic lupeol derivatives inhibitors from the latex of the Tunisian Periploca laevigata, Arab. J. Chem., 10, S2767, 10.1016/j.arabjc.2013.10.026 · DOI
  87. Gang, 2009, Chemical constituents of Periploca forrestii, China J. Chin. Mater. Med., 34, 3225
  88. Srivastava, 1983, Triterpenoids of Periploca calophylla, J. Nat. Prod., 46, 458, 10.1021/np50028a003 · DOI
  89. Gang, 2009, Chemical constituents of Periploca forrestii Schltr, J. Trop. Subtrop. Bot., 17, 160
  90. Ma, 2007, Chemical constituents of stem bark from Periploca sepium, Chem. Nat. Compd., 43, 497, 10.1007/s10600-007-0175-1 · DOI
  91. Wang, 2007, Chemical constituents from root barks of Periploca sepium, China J. Chin. Mater. Med., 32, 1300
  92. Shi, 2007, Structural analysis on four compounds in root bark from Periploca sepium, J. Northwest. Univ., 22, 132
  93. Ogundaini, 1987, Isorhoifolin, a flavonoid glycoside from Periploca nigrescens leaves, Planta Med., 53, 391, 10.1055/s-2006-962750 · DOI
  94. Chen, 2006, Study on anti-tumor active components of Periploca sepium, Chin. Tradit. Herb. Drugs, 37, 519
  95. Wang, 2009, Chemical constituents of Periploca forrestii and their cytotoxicity activity, China J. Chin. Mater. Med., 34, 3214
  96. Li, 2010, Chemical constituents of the root barks of Periploca sepium, Chin. Tradit. Pat. Med., 32, 1552
  97. Guo, 2005, Isolation and structure elucidation of glycosides in n-butanol extracts from rhizome of Periploca calophylla, China J. Chin. Mater. Med., 30, 44
  98. Ishimaru, 1990, Phenyl glucosides grom a hairy root culture of Swertia japonica, Phytochemistry, 29, 3823, 10.1016/0031-9422(90)85340-L · DOI
  99. Wang, 2008, Studies on chemical components of Periploca forrestii Schltr, J. Mt. Agric. Biol., 27, 560
  100. Guan, 2011, Study on the content of the chlorogenic ccid in water extract of Cortex periplocae at the different times by UV, North. Hortic., 35, 177
  101. Komissarenko, 1983, Coumarins and cardenolides from Periploca sepium, Chem. Nat. Compound., 19, 98, 10.1007/BF00579977 · DOI
  102. Wang, 1997, Lignan, phenylpropanoid and iridoid glycosides from Pedicularis torta, Phytochemistry, 45, 159, 10.1016/S0031-9422(96)00770-4 · DOI
  103. Deyama, 1985, The constituents of Eucommia ulmoides Oliv. II. Isolation and structures of three new lignan glycosides, Chem. Pharm. Bull. (Tokyo), 33, 3651, 10.1248/cpb.33.3651 · DOI
  104. Mezhoud, 2016, Flavonoid glycosides from Periploca laevigata (Asclepiadaceae) from Algeria, Pharma. Chem., 8, 129
  105. Zhou, 2010, Glycosides from Periploca forrestii, China J. Chin. Mater. Med., 35, 610
  106. Amina, 2016, Periplocain A, a new naphthalene derivative from Periploca aphylla growing in Saudi Arabia, Helv. Chim. Acta, 99, 466, 10.1002/hlca.201500524 · DOI
  107. Chen, 2019, Preparative separation of the flavonoid fractions from Periploca forrestii Schltr. ethanol extracts using macroporous resin combined with HPLC analysis and evaluation of their biological activities, J. Sep. Sci., 42, 650, 10.1002/jssc.201800422 · DOI
  108. Wang, 2009, Inhibitory effect of Baohuoside I from Cortex Periplocae on esophageal carcinoma cells and its transplantable models in nude mice, Canc. Res. Prev. Treat., 36, 635
  109. Wang, 2010, A diterpenoid quinone from Periploca forrestii, China J. Chin. Mater. Med., 35, 1648
  110. Zhu, 2008, Separation and identification of chemical compounds in Periploca forrestii Schltr, J. Mt. Agric. Biol., 27, 186
  111. Solacolu, 1935, The odoriferant principle of the plant Periploca graeca, J. Pharm. Chim., 22, 546
  112. Shi, 2007, Repellent from traditional chinese medicine, Periploca sepium Bunge, Z. Nat. C, 62, 821
  113. Zhang, J. (2006). Antitumor and immunoregulatory effects of active components from Cortex Periplocae. [Ph.D. Thesis, Hebei Medical University].
  114. Zhao, 2014, Ceramides of Periploca forrestii, Chin. J. Exp. Tradit. Med. Formulae, 20, 83
  115. MacKeith, 1926, Pharmacological properties of Periplocin, J. Pharm., 27, 449
  116. Levi, 1932, The use of the “greek” Periploca in heart diseases, Rev. Sud-Am. Endocrinol. Immunol. Quim., 15, 610
  117. Teng, 1964, Cardiotonic action of a glucosidal preparation obtained from Periploca forrestii, Acta Pharm. Sin., 11, 75
  118. Deng, 1980, Cardiotonic action of Periploca calophylla (Wight.) Falconer, Acta Pharm. Sin., 15, 245
  119. Ma, 2008, Effect of periplocin on left ventricular structure and function in chronic heart failure rats by color doppler-echocardiography, J. Tianjin Univ. Tradit. Chin. Med. (2006-), 27, 81
  120. Ma, 2009, Effect of Periplocin on expression of myocardial PLB and SERCA mRNA in rats with chronic heart failure, Jiangsu J. Tradit. Chin. Med. (2002-), 41, 71
  121. Wang, 2010, Gene expression profiling of the proliferative effect of periplocin on mouse cardiac microvascular endothelial cells, Chin. J. Integr. Med., 16, 33, 10.1007/s11655-010-0033-z · DOI
  122. Sun, 2011, Comparison of the effect of cardiac glycosides in Periplocae Cortex on isolated heart in rats, Chin. Arch. Tradit. Chin. Med., 29, 2633
  123. Li, 2008, Experimental study on the anti-inflammatory and analgesic effects of Periploca forrestii Schlechter, Yunnan J. Tradit. Chin. Med., 29, 35
  124. Wu, 2010, Anti-inflammatory and immun modulation activities from active fraction of Periploca forrestii Schltr, Her. Med., 29, 1425
  125. Song, 2012, Anti-inflammatory effects and mechanism of emulsion of volatile oil from Periploca forrestii, Chin. J. Exp. Tradit. Med. Formulae, 18, 252
  126. Dong, 2017, In vivo and in vitro anti-inflammatory effects of ethanol fraction from Periploca forrestii Schltr, Chin. J. Integr. Med., 23, 528, 10.1007/s11655-017-2803-3 · DOI
  127. Tlili, 2018, Potential health advantages of Periploca laevigata: Preliminary phytochemical analysis and evaluation of in vitro antioxidant capacity and assessment of hepatoprotective, anti-inflammatory and analgesic effects, J. Funct. Foods, 48, 234, 10.1016/j.jff.2018.06.028 · DOI
  128. Wang, B.X. (1997). Pharmacology of Modern Chinese Medicine, Tianjin Science and Technology Press.
  129. Gu, 2008, Effect of periplogenin on mast cell degranulation and histamine release, China Pharm. (ChongqingChina), 19, 166
  130. Wan, 2008, Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents Concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions, Int. Immunopharmacol., 8, 1248, 10.1016/j.intimp.2008.05.001 · DOI
  131. Zhu, 2005, Periplocoside E, and effective compound from Periploca sepium Bge, inhibited T cell activation in vitro and in vivo, J. Pharm. Exp., 316, 662, 10.1124/jpet.105.093732 · DOI
  132. Deng, 2018, Effects of an immunosuppressive active component of Periplocae Cortex (Periploca sepium Bge.) on positive selection of thymocytes in vitro, J. Tradit. Chin. Med Sci., 5, 161
  133. Zhang, 2009, Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells, Acta Pharm. Sin, 30, 1144, 10.1038/aps.2009.101 · DOI
  134. Zhang, 2006, Effects on differentiation and maturation of dendritic cells by lupane acetate of Cortex Periplocae, Chin. J. Cell. Mol. Immunol., 22, 26
  135. Shan, 2008, Effect of Cortex Periplocae lupane acetate on immunoregulation of human peripheral blood lymphocytes, Chin. Tradit. Herb. Drugs, 39, 1035
  136. Zhang, 2009, Immunoregulatory effects of Periplocin from Cortex Periplocae in tumor-bearing mice, Chin. J. Cell. Mol. Immunol., 25, 887
  137. Zhang, 2011, Cellular immunosuppression effect of polysaccharide HGT-5A from Periploca forrestii Schlechter and its possible active components, Chin. J. Pharm. Toxicol., 25, 538
  138. Liang, 2017, Optimized microwave-assistant extraction combined ultrasonic pretreatment of flavonoids from Periploca forrestii Schltr. and evaluation of its anti-allergic activity, Electrophoresis, 38, 1113, 10.1002/elps.201600515 · DOI
  139. Tokiwa, 2004, Oriental medicinal herb, Periploca sepium, extract inhibits growth and IL-6 production of human synovial fibroblast-like cells, Biol. Pharm. Bull., 27, 1691, 10.1248/bpb.27.1691 · DOI
  140. Liu, 2018, The mechanism of Periploca forrestii by regulating the inflammatory response on CIA rat model, J. Chin. Med. Mater., 42, 713
  141. Huang, 2011, Effects and molecular mechanism of Periploca forrestii against rheumatoid arthritis, Chin. J. Exp. Tradit. Med. Formulae, 17, 174
  142. Liang, 2015, Effects of Periploca forrestii ethanol extract (PFE) on proliferation, COX-2 expression, and PG2 expression of rheumatoid arthritis synovial fibroblasts from patients, Lishizhen Med. Mater. Med. Res., 26, 24
  143. Chen, 2017, The therapeutic effects of Periploca forrestii Schltr. Stem extracts on collagen-induced arthritis by inhibiting the activation of Src/NF-kappaB signaling pathway in rats, J. Ethnopharmacol., 202, 12, 10.1016/j.jep.2017.03.005 · DOI
  144. Li, 2016, Studies on the effective components of Periploca forrestii for anti-rheumatoid arthritis, J. Chin. Med. Mater., 39, 649
  145. Liu, 2016, Periploca forrestii saponin ameliorates murine CFA-induced arthritis by suppressing cytokine production, Mediat. Inflamm., 2016, 7941684, 10.1155/2016/7941684 · DOI
  146. Bao, C.M., Liu, Y.Q., Sun, X., Xing, C.C., Zeng, L.T., and Sun, G.C. (2017). Periploca forrestii saponin ameliorates CIA via suppressing proinflammatory cytokines and nuclear factor kappa-B pathways. PLoS ONE, 12. · DOI
  147. Liu, T., Wang, X., He, Y.L., Wang, Y., Dong, L., Ma, X., Zheng, L., Liu, C.H., Wang, G.C., and Zheng, J. (2018). In vivo and in vitro anti-arthritic effects of cardenolide-rich and caffeoylquinic acid-rich fractions of Periploca forrestii. Molecules, 23. · DOI
  148. Zhang, 2008, Periplocin of Cortex Periplocae inhibits Stat3 signaling and induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721, Acta Acad. Med. Mil. Tert., 30, 1448
  149. Du, 2009, Periplocin extracted from Cortex Periplocae induces apoptosis of SW480 cells through inhibiting the Wnt/β-catenin signaling pathway, Chin. J. Cancer (1982–2010), 28, 456
  150. Zhang, 2015, Effects of Periplocin from Cortex Periplocae on apoptosis of human lung cancer A549 cells and expression of survivin, Her. Med., 34, 705
  151. Zhang, 2010, Effects of periplocin from Cortex Periplocae on cell cycle of MCF-7 cells and expression of p21WAFI/CIPI, Canc. Res. Prev. Treat., 37, 864
  152. Lu, 2010, Periplocin inhibits growth of lung cancer in vitro and in vivo by blocking AKT/ERK signaling pathways, Cell. Physiol. Biochem., 26, 609, 10.1159/000322328 · DOI
  153. Cheng, 2013, Antitumor effect of Periplocin in Trail-resistant human hepatocellular carcinoma cells through downregulation of IAPs, Evid. Based Complement. Altern. Med., 2013, 958025, 10.1155/2013/958025 · DOI
  154. Lohberger, 2018, Periplocin, the most anti-proliferative constituent of Periploca sepium, specifically kills liposarcoma cells by death receptor mediated apoptosis, Phytomedicine, 51, 162, 10.1016/j.phymed.2018.10.008 · DOI
  155. Bloise, 2009, Pro-apoptotic and cytostatic activity of naturally occurring cardenolides, Cancer Chemother. Pharm., 64, 793, 10.1007/s00280-009-0929-5 · DOI
  156. Martey, 2014, Periplocymarin is a potential natural compound for drug development: Highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions, Biopharm. Drug Dispos., 35, 195, 10.1002/bdd.1884 · DOI
  157. Liu, 2009, Effect of Baohuoside-I on proliferat ion and cell cycle of human esophageal carcinoma cell Eca-109, Chin. Tradit. Herb. Drugs, 40, 1590
  158. Wang, 2011, The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via β-catenin-dependent signaling, Oncol. Rep., 26, 1149
  159. Wang, 2012, Inhibitory effects of lupeal acetate of Cortex periplocae on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis, Oncol. Lett., 4, 231, 10.3892/ol.2012.717 · DOI
  160. Shan, 2008, Effects of Periplocin on proliferation of human esophageal carcinoma cell TE-13 and its relation with Rb expression, Carcinog. Teratog. Mutagen., 20, 342
  161. Zhao, 2009, Periplocin (a sort of ethanol from Cortexperiplocae) induces apoptosis of esophageal carcinoma cells by influencing expression of related genes, Tumor, 29, 1025
  162. Shan, 2010, Ethylacetate extract from Cortex periplocae induced apoptosis of human esophageal carcinoma cellline TE-13, Tumor, 30, 6
  163. Liang, 2011, Anti-tumor activity of extract from Periploca forrestii, Chin. J. Exp. Tradit. Med. Formulae, 17, 119
  164. Li, 2008, The study of Cortex Periplocae extract on the differentiation of K562 cells, Carcinog. Teratog. Mutagen., 20, 449
  165. Shan, 2005, Inductive ef fect of Cortex Periplocae extract on apoptosis of human gastric cancer cells BGC-823, Chin. Tradit. Herb. Drugs, 36, 1184
  166. Hichri, 2003, Antibacterial activities of a few prepared derivatives of oleanolic acid and of other natural triterpenic compounds, C. R. Chim., 6, 473, 10.1016/S1631-0748(03)00066-3 · DOI
  167. Song, 2013, Chemical constituents of petroleum ether extracts from Periploca forrestii and its antimicrobial effects, Lishizhen Med. Mater. Med. Res., 24, 1085
  168. Hajji, 2010, Chemical composition, angiotensin I-converting enzyme (ACE) inhibitory, antioxidant and antimicrobial activities of the essential oil from Periploca laevigata root barks, Food Chem., 121, 724, 10.1016/j.foodchem.2010.01.021 · DOI
  169. Boualy, 2017, Chemical composition, antioxidant and evidence antimicrobial synergistic effects of Periploca laevigata essential oil with conventional antibiotics, Ind. Crop. Prod., 109, 746, 10.1016/j.indcrop.2017.09.028 · DOI
  170. Wang, 2010, Antimicrobial and antioxidant activities of the root bark essential oil of Periploca sepium and its main component, Molecules, 15, 5807, 10.3390/molecules15085807 · DOI
  171. Jeong, 2018, Antimicrobial agents of 4-methoxysalicylaldehyde isolated from Periploca sepium oil against foodborne bacteria: Structure-activity relationship, Appl. Biol. Chem., 61, 397, 10.1007/s13765-018-0373-5 · DOI
  172. Mohamed, 2009, Chemical composition and antioxidant and radical-scavenging activities of Periploca laevigata root bark extracts, J. Sci. Food Agric., 89, 897, 10.1002/jsfa.3532 · DOI
  173. Wang, X.L., Zhang, Y.F., Liu, Z.K., Zhao, M.Q., and Liu, P.F. (2017). Purification, characterization, and antioxidant activity of polysaccharides isolated from Cortex Periplocae. Molecules, 22. · DOI
  174. Hajji, 2019, Structural characterization, antioxidant and antibacterial activities of a novel polysaccharide from Periploca laevigata root barks, Carbohyd. Polym., 206, 380, 10.1016/j.carbpol.2018.11.020 · DOI
  175. Athmouni, 2019, Characterization of polysaccharides isolated from Periploca angustifolia and its antioxidant activity and renoprotective potential against cadmium induced toxicity in HEK293 cells and rat kidney, Int. J. Biol. Macromol., 125, 730, 10.1016/j.ijbiomac.2018.12.046 · DOI
  176. Athmouni, 2018, Optimization, antioxidant properties and GC-MS analysis of Periploca angustifolia polysaccharides and chelation therapy on cadmium-induced toxicity in human HepG2 cells line and rat liver, Int. J. Biol. Macromol., 108, 853, 10.1016/j.ijbiomac.2017.10.175 · DOI
  177. Athmouni, 2018, Phenolic compounds analysis, antioxidant, and hepatoprotective effects of Periploca angustifolia extract on cadmium-induced oxidative damage in HepG2 cell line and rats, Arch. Physiol. Biochem., 124, 261, 10.1080/13813455.2017.1395890 · DOI
  178. Ali, 2018, Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats, Biomed. Pharm., 105, 1117, 10.1016/j.biopha.2018.06.039 · DOI
  179. Abbas, 2017, Green synthesised zinc oxide nanostructures through Periploca aphylla extract shows tremendous antibacterial potential against multidrug resistant pathogens, Iet Nanobiotechnol., 11, 935, 10.1049/iet-nbt.2016.0238 · DOI
  180. Zhu, 2006, Effects of the crude extracts from Periploca sepium Bunge on the bioactivity of imported cabbage worm Pieris rapae, Chin. J. Eco-Agric., 14, 185
  181. Zhu, 2004, Study on antifeedant and insecticidal activities of extracts and fractions from Periploca sepium Bunge against Plutella xylostella (L.), Chin. J. Pestic. Sci., 6, 48
  182. Mothana, 2012, Study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from Saudi Arabia, Molecules, 17, 11379, 10.3390/molecules171011379 · DOI
  183. Shi, 2006, Chemical components and insecticidal activity of essential oil in Periploca sepium root bark to Schizaphis graminum, Acta Bot. Boreali-Occident. Sin., 26, 620
  184. Chua, 2012, Insecticidal activity of the root bark essential oil of Periploca sepium Bunge and its main component, Nat. Prod. Res., 26, 926, 10.1080/14786419.2010.534991 · DOI
  185. Jeong, 2012, Food protective effects of Periploca sepium oil and its active component against stored food mites, J. Food Prot., 75, 118, 10.4315/0362-028X.JFP-11-315 · DOI
  186. Li, 2013, Effects of periplocoside X on midgut cells and digestive enzymes activity of the soldiers of red imported fire ant, Ecotoxicol. Env. Saf., 93, 1, 10.1016/j.ecoenv.2013.03.011 · DOI
  187. Zhao, 2008, The insecticidal activity of Periplocoside NW, Chin. Bull. Entomol., 45, 950
  188. Feng, 2014, Histopathological effects and immunolocalization of Periplocoside NW from Periploca sepium Bunge on the midgut epithelium of Mythimna separata Walker larvae, Pestic Biochem. Physiol., 115, 67, 10.1016/j.pestbp.2014.09.001 · DOI
  189. Shi, 2012, Isolation of the insecticidal ingredients from Periploca sepium, Chin. J. Pestic. Sci., 14, 103
  190. Chen, 2012, Effects of Periplocosides P and E from Periploca sepium on the proteinase activities in the midgut of larvae of Mythimna separata and Agrotis ypsilon (Lepidoptera: Noctuidae), Acta Entomol. Sin., 55, 412
  191. Wang, 2016, Effects of Periplocin P and E from Periploca sepium on activities of three detoxification enzymes in midgut of Mythimna separata and Agrotis ypsilon (Lepidoptera: Noctuidae), Acta Agric. Boreali-Occident. Sin., 25, 939
  192. Wang, 2016, Effects of Periplocoside P from Periploca sepium on the midgut transmembrane potential of Mythimna separata Larvae, Sci. Rep., 6, 36982, 10.1038/srep36982 · DOI
  193. Feng, M.X., Li, Y.K., Chen, X.T., Wei, Q.S., Wu, W.J., and Hu, Z.N. (2018). Comparative proteomic analysis of the effect of Periplocoside P from Periploca sepium on brush border membrane vesicles in midgut epithelium of Mythimna separata Larvae. Toxins, 10. · DOI
  194. Feng, M.X., He, Z.Y., Wang, Y.Y., Yan, X.F., Zhang, J.W., Hu, Z.N., and Wu, W.J. (2016). Isolation of the binding protein of Periplocoside E from BBMVs in midgut of the oriental amyworm Mythimna separata walker (lepidoptera: Noctuidae) through affinity chromatography. Toxins, 8. · DOI
  195. Zhang, 2012, Experimental study on the treatment of nerve injury caused by Pristionchus pacificus by Periploca forrestii Schltr, Lishizhen Med. Mater. Med. Res., 23, 2758
  196. Jabbar, 2016, Studies on neuropharmacological and analgesic effects of Periploca aphylla extract in mice, Pure Appl. Biol., 5, 1207, 10.19045/bspab.2016.50145 · DOI
  197. Chen, 2018, Chemical profiling and the potential active constituents responsible for wound healing in Periploca forrestii Schltr, J. Ethnopharmacol., 224, 230, 10.1016/j.jep.2018.04.023 · DOI
  198. Chen, 2019, Periplocin promotes wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase, Phytomedicine, 57, 72, 10.1016/j.phymed.2018.12.015 · DOI
  199. Belay, 2018, Antimalarial activity of stem bark of Periploca linearifolia during early and established plasmodium infection in mice, Evid. Based Complement. Altern. Med., 2018, 4169397, 10.1155/2018/4169397 · DOI
  200. Sun, 2010, Experimental comparison study on mice’s acute toxicity of different composition in Cortex Periplocae, Chin. J. Pharm., 7, 579

200 of 209 shown

Cited by

Sorted by citations

See all 33

Metadata

Authors
Huang, M., Shen, S., Luo, C., & Ren, Y.
Affiliations
  • College of Agriculture, Guizhou University, Guiyang 550025, Guizhou, China
  • School of Pharmacy, Yancheng Teachers’ University, Yancheng 224002, Jiangsu, China
  • College of Pharmacy, Guizhou University, Guiyang 550025, Guizhou, China
Venue
Molecules
Publisher
MDPI AG
Published
2019-07-29
Volume
24
Issue
15
Pages
2749
ISSN
1420-3049
DOI
10.3390/molecules24152749
PMC
PMC6696197
Cited by
33
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Construction Program of Biology First-class Discipline in Guizhou (GNYL [2017] 009)
  • Guizhou Science & Technology Foundation ([2013] 2095)
  • Doctor Foundation of Guizhou University ([2010] 018)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review