CoChat
Sign Up
Cited by 146Hydrogels: synthesis, properties, applicationsProteoglycans and glycosaminoglycans researchCollagen: Extraction and Characterization

Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review

Open access
Sionkowska, Alina, Gadomska, Magdalena, Musiał, Katarzyna, Piątek, Jacek·2020·Molecules
DOI 10.3390/molecules25184035PMC PMC7570474
Open this paper in CoChat — free accountOpen PDF

Abstract

In this review, we provide a report on recent studies in the field of research on the blends of hyaluronic acid with other natural polymers, namely collagen and chitosan. Hyaluronic acid has attracted significant interest in biomedical and cosmetic applications due to its interesting properties. In recent years, blends of hyaluronic acid with other polymers have been studied for new materials development. New materials may show improved properties that are important in the biomedical applications and in cosmetic preparations. In this review paper, the structure, preparation, and properties of hyaluronic acid blends with collagen and chitosan have been discussed and examples of new materials based on such blends have been presented. A comparison of the currently available information in the field has been shown. Future aspects in the field of hyaluronic acid blends and their applications in the biomedical and cosmetic industry have also been mentioned.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/molecules25184035

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • HA is non-immunogenic and has a capacity for modifying biological responses, positioning it as an ideal candidate for surgical applications, particularly prevention of post-surgical adhesions including those from peritoneal injury.

    “Its non-immunogenic nature and capacity for modifying biological responses have positioned it as an ideal candidate for surgical applications, particularly in the prevention of post-surgical adhesions, including those arising from peritoneal injury [117].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [117]

    The Introduction says HA can modify cellular behavior and is used for therapeutic purposes, supporting the claim about biological responses. The section on HA–collagen blends reports little inflammatory response to one hydrogel, but does not establish that HA itself is non-immunogenic. No passage found addresses prevention of post-surgical adhesions or those arising from peritoneal injury. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 99

  1. [1]Schante C. Zuber G. Herlin C. Vandamme T. Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications Carbohydr. Polym. 2011 85 469 489 10.1016/j.carbpol.2011.03.019 · DOI
  2. [2]Vasvani S. Kulkarni P. Rawtani D. Hyaluronic acid: A reviewon its biology, aspects of drug delivery, route ofadministrations and a special emphasis on its approved marketedproducts and recent clinical studies Int. J. Biol. Macromol. 2020 151 1012 1029 10.1016/j.ijbiomac.2019.11.066 31715233 · DOI
  3. [3]Al-Sibani M. Al-Harrasi A. Neubert R.H.H. Effect of hyaluronic acid initial concentration on cross-linking efficiency of hyaluronic acid-based hydrogels used in biomedical and cosmetic applications Pharmazie 2017 72 81 86 29441857
  4. [4]Luo Y. Kirker K.R. Prestwich G.D. Cross-linked hyaluronic acid hydrogel films: New biomaterials for drug delivery J. Control. Release 2008 69 169 184 10.1016/S0168-3659(00)00300-X 11018555 · DOI
  5. [5]Berko S. Maroda M. Bondar M. Eros G. Hartmann P. Szentner K. Szabo-Revesz P. Kemeny L. Borbely J. Csanyi E. Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems Eur. Polym. J. 2013 49 2511 2517 10.1016/j.eurpolymj.2013.04.001 · DOI
  6. [6]Masters K.S. Shah D.N. Leinwand L.A. Anseth K.S. Crosslinked hyaluronan scaffolds as a biologically active carrier for valvular interstitial cells Biomaterials 2005 26 2517 2525 10.1016/j.biomaterials.2004.07.018 15585254 · DOI
  7. [7]Kim I.L. Mauck R.L. Burdick J.A. Hydrogel design for cartilage tissue engineering: A case study with hyaluronic acid Biomaterials 2011 32 8771 8782 10.1016/j.biomaterials.2011.08.073 21903262 PMC3183132 · DOI
  8. [8]Bukhari S.N. Roswandi N.L. Waqas M. Habib H. Hussain F. Khan S. Sohail M. Ramli N.A. Thu H.E. Hussain Z. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects Int. J. Biol. Macromol. 2018 120 1682 1695 10.1016/j.ijbiomac.2018.09.188 30287361 · DOI
  9. [9]Ievdokimova N.I. Hyaluronic acid, receptor CD44, and their role in diabetic complications Ukr. Kyi Biokhimichnyi Zhurnal 2008 80 5 44 19248616
  10. [10]Papakonstantinou E. Roth M. Karakiulakis G. Hyaluronic acid: A key molecule in skin aging Dermatoendocrinol 2012 4 253 258 10.4161/derm.21923 23467280 PMC3583886 · DOI · Paper page
  11. [11]Narurkar V.A. Fabi S.G. Bucay V.W. Tedaldi R. Downie J.B. Zeichner J.A. Butterwick K. Taub A. Kadoya K. Makino E.T. Rejuvenating hydrator: Restoring epidermal hyaluronic acid homeostasis with instant benefits J. Drugs Dermatol. 2016 15 24 37 26741392
  12. [12]Pavicic T. Gauglitz G.G. Lersch P. Schwach-Abdellaoui K. Malle B. Korting H.C. Farwick M. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment J. Drugs Dermatol. 2011 10 990 1000 22052267
  13. [13]Brandt F. Bassichis B. Bassichis M. O’Connell C. Lin X. Safety and effectiveness of small and large gel-particle hyaluronic acid in the correction of perioral wrinkles J. Drugs Dermatol. 2011 10 982 987 22052266
  14. [14]Rzany B. Cartier H. Kestemont P. Trevidic P. Sattler G. Kerrouche N. Dhuin J.C. Ma M.Y. Full-face rejuvenation using a range of hyaluronic acid fillers: Efficacy, safety, and patient satisfaction over 6 months Dermatol. Surg. 2012 38 1153 1161 10.1111/j.1524-4725.2012.02470.x 22759252 · DOI
  15. [15]Streit M. Brand C.U. Braathen L.R. Soft tissue augmentation for treatment of wrinkles and scars of the face Ther. Umsch. 1999 56 212 218 10.1024/0040-5930.56.4.212 10330883 · DOI
  16. [16]Sionkowska A. The potential of polymers from naturals sources as components of the blends for biomedical and cosmetic applications Pure Appl. Chem. 2015 87 1075 1084 10.1515/pac-2015-0105 · DOI
  17. [17]Xie H. Chen X. Shen X. He Y. Chen W. Luo Q. Ge W. Yuan W. Tang X. Hou D. Preparation of chitosan-collagen-alginate composite dressing and its promoting effects on wound healing Int. J. Biol. Macromol. 2018 107 93 104 10.1016/j.ijbiomac.2017.08.142 28860056 · DOI
  18. [18]Vieira S. Strymecka P. Stanaszek L. Silva-Correia J. Drela K. Fiedorowicz M. Malysz-Cymborska I. Rogujski P. Janowski M. Reis R.L. Methacrylated gellan gum and hyaluronic acid hydrogel blends for image-guided neurointerventions J. Mat. Chem. B 2020 8 5928 5937 10.1039/D0TB00877J 32542280 · DOI
  19. [19]Ronca A. D’Amora U. Raucci M.G. Lin H. Fan Y.J. Zhang X.D. Ambrosio L. A Combined Approach of Double Network Hydrogel and Nanocomposites Based on Hyaluronic Acid and Poly (ethylene glycol) Diacrylate Blend Materials 2018 11 2454 10.3390/ma11122454 PMC6316897 30518026 · DOI
  20. [20]Pokorny M. Rassushin V. Wolfova L. Velebny V. Increased Production of Nanofibrous Materials by Electroblowing from Blends of Hyaluronic Acid and Polyethylene Oxide Polym. Eng. Sci. 2016 56 932 938 10.1002/pen.24322 · DOI
  21. [21]Sionkowska A. Skrzyński S. Śmiechowski K. Kołodziejczak A. The review of versatile application of collagen Polym. Adv. Technol. 2017 28 4 9 10.1002/pat.3842 · DOI
  22. [22]Taguchi T. Tanaka J. Swelling behavior of hyaluronic acid and type II collagen hydrogels prepared by using conventional crosslinking and subsequent additional polymer interactions J. Biomater. Sci. Polym. Ed. 2002 13 43 52 10.1163/156856202753525927 12003074 · DOI
  23. [23]Chung E.J. Jakus A.E. Shah R.N. In situ forming collagen-hyaluronic acid membrane structures: Mechanism of self-assembly and applications in regenerative medicine Acta Biomater. 2013 9 5153 5161 10.1016/j.actbio.2012.09.021 23022546 · DOI
  24. [24]Taguchi T. Ikoma T. Tanaka J. An improved method to prepare hyaluronic acid and type II collagen composite matrices J. Biomed. Mater. Res. 2002 61 330 336 10.1002/jbm.10147 12007214 · DOI
  25. [25]Park S.N. Lee H.J. Lee K.H. Suh H. Biological characterization of EDC-crosslinked collagen-hyaluronic acid matrix in dermal tissue restoration Biomaterials 2003 24 1631 1641 10.1016/S0142-9612(02)00550-1 12559823 · DOI
  26. [26]Lin Y.K. Liu D.C. Studies of novel hyaluronic acid-collagen sponge materials composed of two different species of type I collagen J. Biomater. Appl. 2007 21 265 281 10.1177/0885328206063502 16543285 · DOI
  27. [27]Lee S.J. Kim S.Y. Lee Y.M. Preparation of porous collagen/hyaluronic acid hybrid scaffolds for biomimetic functionalization through biochemical binding affinity J. Biomed. Mater. Res. B Appl. Biomater. 2007 82B 506 518 10.1002/jbm.b.30756 17279566 · DOI
  28. [28]Fujie T. Furutate S. Niwa D. Takeoka S. A nano-fibrous assembly of collagen-hyaluronic acid for controlling cell-adhesive properties Soft Matter 2010 6 4672 4676 10.1039/c0sm00527d · DOI
  29. [30]Liu Y. Fan D. Novel hyaluronic acid-tyrosine/collagen-based injectable hydrogels as soft filler for tissue engineering Int. J. Biol. Macromol. 2019 141 700 712 10.1016/j.ijbiomac.2019.08.233 31473315 · DOI
  30. [31]Ying H.Y. Zhou J. Wang M.Y. Su D.D. Ma Q.Q. Lv G.Z. Chen J.H. In situ formed collagen-hyaluronic acid hydrogel as biomimetic dressing for promoting spontaneous wound healing Mater. Sci. Eng. C-Mater. Biol. Appl. 2019 101 487 498 10.1016/j.msec.2019.03.093 31029343 · DOI
  31. [32]Zhang J.J. Ma X.X. Fan D.D. Zhu C.H. Deng J.J. Hui J.F. Ma P. Synthesis and characterization of hyaluronic acid/human-like collagen hydrogels Mater. Sci. Eng. C-Mater. Biol. Appl. 2014 43 547 554 10.1016/j.msec.2014.07.058 25175249 · DOI
  32. [33]Segura T. Chung P.H. Shea L.D. DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach Biomaterials 2005 26 1575 1584 10.1016/j.biomaterials.2004.05.007 15522759 PMC2648403 · DOI
  33. [34]Mineo A. Suzuki R. Kuroyanagi Y. Development of an artificial dermis composed of hyaluronic acid and collagen J. Biomater. Sci. Polym. Ed. 2013 24 726 740 10.1080/09205063.2012.708190 23565912 · DOI
  34. [35]Kondo S. Niiyama H. Yu A. Kuroyanagi Y. Evaluation of a wound dressing composed of hyaluronic acid and collagen sponge containing epidermal growth factor in diabetic mice J. Biomater. Sci. Polym. Ed. 2012 23 1729 1740 10.1163/092050611X597799 21943516 · DOI
  35. [36]Kondo S. Kuroyanagi Y. Development of a wound dressing composed of hyaluronic acid and collagen sponge with epidermal growth factor J. Biomater. Sci. Polym. Ed. 2012 23 629 643 10.1163/092050611X555687 21375805 · DOI
  36. [37]Yu A. Niiyama H. Kondo S. Yamamoto A. Suzuki R. Kuroyanagi Y. Wound dressing composed of hyaluronic acid and collagen containing EGF or bFGF: Comparative culture study J. Biomater. Sci. Polym. Ed. 2013 24 1015 1026 10.1080/09205063.2012.731375 23647255 · DOI
  37. [38]Kim Z.H. Lee Y. Kim S.M. Kim H. Yun C.K. Choi Y.S. A composite dermal filler comprising cross-linked hyaluronic acid and human collagen for tissue reconstruction J. Microbiol. Biotechnol. 2015 25 399 406 10.4014/jmb.1411.11029 25502824 · DOI
  38. [39]Kim T.G. Chung H.J. Park T.G. Macroporous and nanofibrous hyaluronic acid/collagen hybrid scaffold fabricated by concurrent electrospinning and deposition/leaching of salt particles Acta Biomater. 2008 4 1611 1619 10.1016/j.actbio.2008.06.008 18640884 · DOI
  39. [40]Fischer R.L. McCoy M.G. Grant S.A. Electrospinning collagen and hyaluronic acid nanofiber meshes J. Mater. Sci. Mater. Med. 2012 23 1645 1654 10.1007/s10856-012-4641-3 22528074 · DOI
  40. [41]Nazir R. Collagen—hyaluronic acid based interpenetrating polymer networks as tissue engineered heart valve Mater. Sci. Technol. 2016 32 871 882 10.1179/1743284715Y.0000000097 · DOI
  41. [42]Crini G. Historical review on chitin and chitosan biopolymers Environ. Chem. Lett. 2019 17 1623 1643 10.1007/s10311-019-00901-0 · DOI
  42. [43]Lewandowska K. Sionkowska A. Grabska S. Chitosan blends containing hyaluronic acid and collagen. Compatibility behaviour J. Mol. Liq. 2015 212 879 884 10.1016/j.molliq.2015.10.047 · DOI
  43. [44]Lewandowska K. Sionkowska A. Grabska S. The influence of the type solvent on the structure of chitosan blends with hyaluronic acid PCACD 2016 21 147 153 10.15259/PCACD.21.15 · DOI
  44. [45]Lalevee G. Sudre G. Montembault A. Meadows J. Malaise S. Crepet A. David L. Delair T. Polyelectrolyte complexes via desalting mixtures of hyaluronic acid and chitosan-Physicochemical study and structural analysis Carbohydr. Polym. 2016 154 86 95 10.1016/j.carbpol.2016.08.007 27577900 · DOI
  45. [46]Kayitmazer A.B. Koksal A.F. Iyilik E.K. Complex coacervation of hyaluronic acid and chitosan: Effects of pH, ionic strength, charge density, chain length and the charge ratio Soft Matter. 2015 11 8605 8612 10.1039/C5SM01829C 26406548 · DOI
  46. [48]Park H. Choi B. Hu J.L. Lee M. Injectable chitosan hyaluronic acid hydrogels for cartilage tissue engineering Acta Biomater. 2013 9 4779 4786 10.1016/j.actbio.2012.08.033 22935326 · DOI
  47. [49]Neethu M. Mohanan P.V. Sabareeswaran A. Prabha N. Chitosan-hyaluronic acid hydrogel for cartilage repair Int. J. Biol. Macromol. 2017 104 1936 1945 28359897
  48. [50]Acar O.K. Kayitmazer A.B. Kose G.T. Hyaluronic acid/chitosan coacervate-based scaffolds Biomacromolecules 2018 19 1198 1211 10.1021/acs.biomac.8b00047 29554416 · DOI
  49. [51]Zhang W. Jin X. Li H. Zhang R.R. Wu C.W. Injectable and body temperature sensitive hydrogels based on chitosan and hyaluronic acid for pH sensitive drug release Carbohydr. Polym. 2018 186 82 90 10.1016/j.carbpol.2018.01.008 29456012 · DOI
  50. [52]Valverde A. Perez-Alvarez L. Ruiz-Rubio L. Olivenza M.A.P. Blanco M.B.G. Diaz-Fuentes M. Vilas-Vilela J.L. Antibacterial hyaluronic acid/chitosan multilayers onto smooth and micropatterned titanium surfaces Carbohydr. Polym. 2019 207 824 833 10.1016/j.carbpol.2018.12.039 30600071 · DOI
  51. [53]Vigani B. Rossi S. Sandri G. Bonferoni M.C. Caramella C.M. Ferrari F. Hyaluronic acid and chitosan-based nanosystems: A new dressing generation for wound care Expert Opin. Drug Deliv. 2019 16 715 740 10.1080/17425247.2019.1634051 31215823 · DOI
  52. [54]Bazmandeh A.Z. Mirzaei E. Ghasemi Y. Kouhbanani M.A.J. Hyaluronic acid coated electrospun chitosan-based nanofibers prepared by simultaneous stabilizing and coating Int. J. Biol. Macromol. 2019 138 403 411 10.1016/j.ijbiomac.2019.07.107 31326513 · DOI
  53. [55]Sun J.F. Perry S.L. Schiffman J.D. Electrospinning Nanofibers from Chitosan/Hyaluronic Acid Complex Coacervates Biomacromolecules 2019 20 4191 4198 10.1021/acs.biomac.9b01072 31613600 · DOI
  54. [56]Lee E.J. Kang E. Kang S.W. Huh K.M. Thermo-irreversible glycol chitosan/hyaluronic acid blend hydrogel for injectable tissue engineering Carbohydr. Polym. 2020 244 116432 10.1016/j.carbpol.2020.116432 32536405 · DOI
  55. [57]Engkagul V. Sereemaspun A. Chirachanchai S. One pot preparation of chitosan/hyaluronic acid-based triple network hydrogel via in situ click reaction, metal coordination and polyion complexation in water Carbohydr. Polym. 2018 200 616 623 10.1016/j.carbpol.2018.07.090 30177207 · DOI
  56. [58]Erickson A.E. Levengood S.K.L. Sun J.L. Chang F.C. Zhang M.Q. Fabrication and Characterization of Chitosan-Hyaluronic Acid Scaffolds with Varying Stiffness for Glioblastoma Cell Culture Adv. Healthc. Mater. 2018 7 1800295 10.1002/adhm.201800295 PMC6116517 29893067 · DOI
  57. [59]Xu H.T. Ma L. Shi H.F. Gao C.Y. Han C.M. Chitosan-hyaluronic acid hybrid film as a novel wound dressing: In vitro and in vivo studies Polym. Adv. Technol. 2007 18 869 875 10.1002/pat.906 · DOI
  58. [60]Iacob A.T. Dragan M. Ghetu N. Pieptu D. Vasile C. Buron F. Routier S. Giusca S.E. Caruntu I.D. Profire L. Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives Polymers 2018 10 607 10.3390/polym10060607 PMC6404145 30966641 · DOI
  59. [61]Mitura S. Sionkowska A. Jaiswal A. Biopolymers for hydrogels in cosmetics: Review J. Mater. Sci. Mater. Med. 2020 31 50 10.1007/s10856-020-06390-w 32451785 PMC7248025 · DOI
  60. [62]Lewandowska K. Sionkowska A. Grabska S. Kaczmarek B. Michalska M. The miscibility of collagen/hyaluronic acid/chitosan blends investigated in dilute solutions and solids J. Mol. Liq. 2016 220 726 730 10.1016/j.molliq.2016.05.009 · DOI
  61. [64]Sionkowska A. Lewandowska K. Grabska S. Kaczmarek B. Michalska M. Physico-chemical properties of three-component mixtures based on chitosan, hyaluronic acid and collagen Mol. Cryst. Liq. Cryst. 2016 640 21 29 10.1080/15421406.2016.1255501 · DOI
  62. [65]Lewandowska K. Sionkowska A. Grabska S. Kaczmarek B. Surface and thermal properties of collagen/hyaluronic acid blends containing chitosan Int. J. Biol. Macromol. 2016 92 371 376 10.1016/j.ijbiomac.2016.07.055 27431790 · DOI
  63. [66]Sionkowska A. Kaczmarek B. Michalska M. Lewandowska K. Grabska S. Preparation and characterization of collagen/chitosan/hyaluronic acid thin films for application in hair care cosmetics Pure Appl. Chem. 2017 89 1829 1839 10.1515/pac-2017-0314 · DOI
  64. [67]Sionkowska A. Michalska-Sionkowska M. Walczak M. Preparation and characterization of collagen/hyaluronic acid/chitosan film crosslinked with dialdehyde starch Int. J. Biol. Macromol. 2020 149 290 295 10.1016/j.ijbiomac.2020.01.262 32004596 · DOI
  65. [68]Sionkowska A. Kaczmarek B. Lewandowska K. Grabska S. Pokrywcznska M. Kloskowski T. Drewa T. 3D composites based on the blends of chitosan and collagen with the addition of hyaluronic acid Int. J. Biol. Macromol. 2016 89 442 448 10.1016/j.ijbiomac.2016.04.085 27151670 · DOI
  66. [69]Kaczmarek B. Sionkowska A. Kozlowska J. Osyczka A.M. New composite materials prepared by calcium phosphate precipitation in chitosan/collagen/hyaluronic acid sponge cross-linked by EDC/NHS Int. J. Biol. Maacromol. 2018 107 247 253 10.1016/j.ijbiomac.2017.08.173 28867232 · DOI
  67. [70]Kaczmarek B. Sionkowska A. Osyczka A.M. The application of chitosan/collagen/hyaluronic acid sponge cross-linked by dialdehyde starch addition as a matrix for calcium phosphate in situ precipitation Int. J. Biol. Maacromol. 2018 107 470 477 10.1016/j.ijbiomac.2017.09.017 28890371 · DOI
  68. [72]Kaczmarek B. Sionkowska A. Osyczka A.M. The comparison of physic-chemical properties of chitosan/collagen/hyaluronic acid composites with nano-hydroxyapatite cross-linked by dialdehyde starch and tannic acid Polym. Test. 2017 62 171 176 10.1016/j.polymertesting.2017.06.027 · DOI · Paper page
  69. [73]Lewandowska-Lancucka J. Gilarska A. Bula A. Horak W. Latkiewicz A. Nowakowska M. Genipin crosslinked bioactive collagen/chitosan/hyaluronic acid injectable hydrogels structurally amended via covalent attachment of surface-modified silica particles Int. J. Biol. Maacromol. 2019 136 1196 1208 10.1016/j.ijbiomac.2019.06.184 31252014 · DOI
  70. [74]Kaczmarek B. Sionkowska A. Golynska M. Polkowska I. Szponder T. Nehrbass D. Osyczka A.M. In vivo study on scaffolds based on chitosan, collagen, and hyaluronic acid with hydroxyapatite Int. J. Biol. Macromol. 2018 118 938 944 10.1016/j.ijbiomac.2018.06.175 29969639 · DOI
  71. [75]Michalska-Sionkowska M. Kaczmarek B. Walczak M. Sionkowska A. Antimicrobial activity of new materials based on the blends of collagen/chitosan/hyaluronic acid with gentamicin sulfate addition Mater Sci. Eng. C Mater Biol. Appl. 2018 86 103 108 10.1016/j.msec.2018.01.005 29525085 · DOI
  72. [76]Hu Y. Wu Y. Cai J. Ma S. Wang X. The procoagulant properties of hyaluronic acid-collagen (i)/chitosan complex film J. Biomater. Sci. Polym. Ed. 2009 20 1111 1118 10.1163/156856209X444457 19454172 · DOI
  73. [77]Wu Y. Hu Y. Cai J. Ma S. Wang X. Coagulation property of hyaluronic acid –collagen/chitosan complex film J. Mater. Sci. Mater. Med. 2008 19 3621 3629 10.1007/s10856-008-3477-3 18642062 · DOI
  74. [78]Sionkowska A. Grabska S. Incorporation of magnetite particles in 3D matrices made from the blends of collagen, chitosan, and hyaluronic acid Adv. Polym. Technol. 2018 37 2905 2914 10.1002/adv.21962 · DOI
  75. [79]Highley C.B. Prestwich G.D. Burdick J.A. Recent advances in hyaluronic acid hydrogels for biomedical applications Curr. Opin. Biotechnol. 2016 40 35 40 10.1016/j.copbio.2016.02.008 26930175 · DOI
  76. [80]Shaharudin A. Aziz Z. Effectiveness of hyaluronic acid and its derivatives on chronic wounds: A systematic review J. Wound Care 2016 25 585 592 10.12968/jowc.2016.25.10.585 27681589 · DOI
  77. [81]Genasetti A. Vigetti D. Viola M. Karousou E. Moretto P. Rizzi M. Bartolini B. Clerici M. Pallotti F. De Luca G. Hyaluronan and human endothelial cell behaviour Connect. Tissue Res. 2008 49 120 123 10.1080/03008200802148462 18661325 · DOI
  78. [82]Jayakumar R. Chennazhi K.P. Srinivasan S. Nair S.V. Furuike T. Tamura H. Chitin scaffolds in tissue engineering Int. J. Mol. Sci. 2011 12 1876 1887 10.3390/ijms12031876 21673928 PMC3111639 · DOI
  79. [83]Peppas N.A. Buri P.A. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues J. Control. Release 1985 2 257 275 10.1016/0168-3659(85)90050-1 · DOI
  80. [84]Lee S.Y. Kang M.S. Jeong W.Y. Dong-Wook H. Kim K.S. Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy Cancers 2020 1 940 10.3390/cancers12040940 32290285 PMC7226393 · DOI
  81. [85]Abou-Okeil A.H. Fahmy M. El-Bisi M.K. Ahmed-Farid O.A. Hyaluronic acid/Naalginate films as topical bioactive wound dressings Eur. Polym. J. 2018 109 101 109 10.1016/j.eurpolymj.2018.09.003 · DOI
  82. [86]Jegasothy S.M. Zabolotniaia V. Bielfeldt S. Efficacy of a new topical nanohyaluronic acid in humans J. Clin. Aest. Dermatol. 2014 7 27 29 PMC3970829 24688623
  83. [87]Amirian J. Makkar P. Lee G.H. Paul K. Lee B.T. Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration Mater. Lett. 2020 272 127830 10.1016/j.matlet.2020.127830 · DOI
  84. [88]Yang S. Zhu B. Yin P. Zhao L. Wang Y. Fu Z. Dang R. Xu J. Zhang J. Wen N. Integration of Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes with Hydroxyapatite-Embedded Hyaluronic Acid-Alginate Hydrogel for Bone Regeneration ACS Biomater. Sci. Eng. 2020 6 1590 1602 10.1021/acsbiomaterials.9b01363 33455380 · DOI
  85. [89]Makvandi P. Ali G.W. Della Sala F. Abdel-Fattah W.I. Borzacchiello A. Hyaluronic acid/corn silk extract based injectable nanocomposite: A biomimetic antibacterial scaffold for bone tissue regeneration Mater. Sci. Eng. C Mater. 2020 107 110195 10.1016/j.msec.2019.110195 31761207 · DOI
  86. [90]Chomoucka J. Drbohlavova J. Huska D. Adam V. Kizek R. Hubalek J. Magnetic nanoparticles and targeted drug delivering Pharmacol. Res. 2010 62 144 149 10.1016/j.phrs.2010.01.014 20149874 · DOI
  87. [91]Ito A. Shinkai M. Honda H. Kobayashi T. Medican application of funcionalized magnetic nanoparticles J. Biosci. Bioeng. 2005 100 1 11 10.1263/jbb.100.1 16233845 · DOI
  88. [92]Dias A.M. Hussain A. Marcos A.S. Roque A.C. A biotechnological perspective on the application of iron oxide magnetic colloids modified with polysaccharides Biotechnol. Adv. 2011 29 142 155 10.1016/j.biotechadv.2010.10.003 20959138 · DOI
  89. [93]Chełminiak D. Ziegler-Borowska M. Kaczmarek H. Polymer coated magnetite nanoparticles for biomedical applications. Part I. Preparation of nanoparticles Fe3O4 coated by polysaccharides Polimery 2015 60 12 17 10.14314/polimery.2015.012 · DOI
  90. [94]Kim S. Cho D.H. Kweon D.K. Jang E.H. Hong J.Y. Lim S.T. Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition Food Sci. Biotechnol. 2020 29 1233 1239 10.1007/s10068-020-00771-1 32802562 PMC7406631 · DOI
  91. [95]Li F. Ducker M. Sun B. Szele F.G. Czernuszka J.T. Interpenetrating polymer networks of collagen, hyaluronic acid, and chondroitin sulfate as scaffolds for brain tissue engineering Acta Biomater. 2020 112 122 135 10.1016/j.actbio.2020.05.042 32512215 · DOI
  92. [96]Ghorbani F. Zamanian A. Behnamghader A. Behnamghader A. Joupari M.D. Bioactive and biostable hyaluronic acid-pullulan dermal hydrogels incorporated with biomimetic hydroxyapatite spheres Mater. Sci. Eng. C Mater. 2020 112 110906 10.1016/j.msec.2020.110906 32409060 · DOI
  93. [97]Guan Y. You H. Cai J. Zhang Q. Yan S.Q. You R.C. Physically crosslinked silk fibroin/hyaluronic acid scaffolds Carbohyd. Polym. 2020 239 116232 10.1016/j.carbpol.2020.116232 32414432 · DOI
  94. [98]Unal S. Arslan S. Yilmaz B.K. Oktar F.N. Ficai D. Ficai A. Gunduz O. Polycaprolactone/Gelatin/Hyaluronic Acid Electrospun Scaffolds to Mimic Glioblastoma Extracellular Matrix Materials 2020 13 2661 10.3390/ma13112661 PMC7321639 32545241 · DOI
  95. [99]Najberg M. Mansor M.H. Taille T. Boure C. Molina-Pena R. Boury F. Cenis J.L. Garcion E. Alvarez-Lorenzo C. Aerogel sponges of silk fibroin, hyaluronic acid and heparin for soft tissue engineering: Composition-properties relationship Carbohydr. Polym. 2020 237 116107 10.1016/j.carbpol.2020.116107 32241442 · DOI
  96. [100]Zineh B.R. Shabgard M.R. Roshangar L. Jahani K. Experimental and numerical study on the performance of printed alginate/hyaluronic acid/halloysite nanotube/polyvinylidene fluoride bio-scaffolds J. Biomech. 2020 104 109764 10.1016/j.jbiomech.2020.109764 32247526 · DOI
  97. [101]Antich C. de Vicente J. Jimenez G. Chocarro C. Carrillo E. Montanez E. Galvez-Martin P. Marchal J.A. Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs ACTA Biomater. 2020 106 114 123 10.1016/j.actbio.2020.01.046 32027992 · DOI
  98. [103]Andrysiak T. Bełdowski P. Siódmiak J. Weber P. Ledzinski D. Hyaluronan-chondroitin sulfate anomalous crosslinking due to temperature changes Polymers 2018 10 560 10.3390/polym10050560 30966594 PMC6415367 · DOI
  99. [104]Dėdinaitė A. Wieland D.C.F. Beldowski P. Claesson P.M. Biolubrication synergy: Hyaluronan–Phospholipid interactions at interfaces Adv. Coll. Interf. Sci. 2019 274 102050 10.1016/j.cis.2019.102050 31669714 · DOI

Cited by

Sorted by citations

Authors
Sionkowska, A., Gadomska, M., Musiał, K., & Piątek, J.
Affiliations
  • Nicolaus Copernicus University (PL)
  • Uniwersytet Kaliski im. Prezydenta Stanisława Wojciechowskiego (PL)
Corresponding author
Sionkowska, Alina
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2020-09-04
Volume
25
Issue
18
Pages
4035
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules25184035
PMC
PMC7570474
OpenAlex
W3082442980
Cited by
146
References
1
Citations by year
2026: 22 · 2025: 29 · 2024: 36 · 2023: 21 · 2022: 23 · 2021: 15
FWCI
1.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Keywords
hyaluronic acid, natural polymer blends, collagen, chitosan, biomedical materials, cosmetic applications, polymer blending, polymer blend properties
MeSH terms
Collagen, Hyaluronic Acid, Polymers, Biomedical Technology, Chitosan

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review