Preparation and characterization of composites based on the blends of collagen, chitosan and hyaluronic acid with nano-hydroxyapatite
Abstract
3D porous composites based on the blend of chitosan, collagen and hyaluronic acid with the addition of nano-hydroxyapatite were prepared. SEM images for the composites were made and the structure was assessed. Mechanical properties were studied using a Zwick&Roell Testing Mashine. In addition, the porosity and density of composites were measured. The concentration of calcium ions released from the material was detected by the complexometric titration method. The results showed that in 3D porous sponge based on the blend of chitosan, collagen and hyaluronic acid, inorganic particles of nanohydroxyapatite can be incorporated, as well as that the properties of 3D composites depend on the material composition. Mechanical parameters and thermal stability of ternary biopolymeric blends were improved by the addition of hydroxyapatite. Moreover, the porosity of ternary materials was higher than in materials based on pure chitosan or collagen. All composites were characterized by a porous structure with interconnected pores. Calcium ions can be released from the composite during its degradation in water.
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A scaffold with better mechanical and thermal properties that can effectively support bone regeneration was prepared.
“Scaffold with better mechanical and [98] | thermal properties that can | effectively support bone | regeneration was prepared.”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [98]
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Karciauskaite, J., Elsheikh, M., Su, C.-Y., Mortimer, M., Valmsen, K., Stankevičiūtė, Ž., Fang, H.-W., & Kareiva, A. (2026) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2026.132882
- Authors
- Sionkowska, A., & Kaczmarek, B.
- Affiliations
- Nicolaus Copernicus University (PL)
- Corresponding author
- Sionkowska, Alina
- ORCID
- Sionkowska, Alina
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 102
- Pages
- 658-666
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2605320162
- Cited by
- 57
- References
- 43
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 12 · 2020: 12 · 2019: 5 · 2018: 9 · 2017: 2
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Centre (UMO-2013/11/B/ST8/04444)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- collagen, chitosan, hyaluronic acid, hydroxyapatite nanoparticles, biopolymer blends, calcium ion release, porosity, mechanical properties, thermal stability, biodegradation, tissue engineering scaffolds
- MeSH terms
- Collagen, Hyaluronic Acid, Durapatite, Chitosan, Nanocomposites, Mechanical Phenomena
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