Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications
Open accessAbstract
Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Photo-responsive smart nanoparticles have gained significant interest as controlled drug delivery systems in the field of cancer smart nanoparticle therapy because they can provide geographic and temporal control of the release of the encapsulated medicines on demand via light irradiation.
“Since they can provide geographic and temporal control of the release of the encapsulated medicines on demand via light irradiation, photo-responsive smart nanoparticles have gained significant interest as controlled drug delivery systems in the field of cancer smart nanoparticle therapy.174”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [174]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 38 · Cited by 46
- Authors
- Hou, W., Liu, R., Bi, S., He, Q., Wang, H., & Gu, J.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Wang, Haibo
- Gu, Jun
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2020-11-05
- Volume
- 25
- Issue
- 21
- Pages
- 5147
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC7663911
- OpenAlex
- W3097836629
- Cited by
- 46
- References
- 38
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 9 · 2023: 13 · 2022: 8 · 2021: 5
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- the Sichuan Science and Technology Program, China (2019YFS0344, 2019YFS0251, 2019YFS0352)
- the National Natural Science Foundation of China (Grant No. 81700410)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- poly(N,N-dimethylacrylamide), amphiphilic block copolymers, RAFT polymerization, photocleavage, stimuli-responsive drug delivery, self-assembly, cancer therapy
- MeSH terms
- Acrylamides, Acrylates, Doxorubicin, Magnetic Resonance Spectroscopy, Photochemistry, Polyethylene Glycols, Polymers, Polystyrenes, Drug Delivery Systems, Nanoparticles, Hydrophobic and Hydrophilic Interactions, Polymerization, Chemistry Techniques, Synthetic, Drug Liberation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
