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Cited by 39Mangiferin and Mango ExtractsWound Healing and TreatmentsPhytochemistry and biological activity of medicinal plants

The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model

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Espinosa-Espinosa, Lesslie, Garduño-Siciliano, Leticia, Rodriguez-Canales, Mario, Hernandez-Portilla, Luis Barbo, Canales-Martinez, Maria Margarita, Rodriguez-Monroy, Marco Aurelio·2022·Molecules
DOI 10.3390/molecules27010259PMC PMC8746551
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Abstract

Mangifera indica can generate up to 60% of polluting by-products, including peels. However, it has been shown that flavonoids and mangiferin are mainly responsible for the antioxidant, anti-inflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was analyzed by HPLC-DAD, as well as concentrations of total phenol (TPC) and flavonoids (TFC) and antioxidant activity (SA50). Wound-healing efficacy was determined by measurements of wound contraction, histological analysis, and tensiometric method; moreover, anti-inflammatory, antibacterial, and acute dermal toxicity (OECD 402) were also evaluated. Phenol, resorcinol, conjugated resorcinol, and mangiferin were detected. TPC, TFC, and SA50 were 136 mg GAE/g, 101.66 mg QE/g, and 36.33 µg/mL, respectively. Tensile strength and wound contraction closure did not show significant differences between MEMI and dexpanthenol groups. Histological analysis (after 14 days) shows a similar architecture between MEMI treatment and normal skin. MEMI exhibits a reduction in edema. Staphylococcus epidermidis had an MIC of 2 mg/mL, while Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli reached 4 mg/mL. The MEMI showed no signs of toxicity. Therefore, this study demonstrates multiple targets that flavonoids and mangiferin of MEMI may present during the healing process.

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  • MGF exerts protective effects across a broad spectrum of pathological conditions, including inflammatory, neurodegenerative, ocular, renal, cardiovascular, dermatological and infectious diseases.

    “In addition to its well-characterized roles in diabetes and cancer, MGF exerts protective effects across a broad spectrum of pathological conditions. These include inflammatory, neurodegenerative, ocular, renal, cardiovascular, dermatological and infectious diseases (7,36,106,115-118).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [118]

    The Discussion describes mangiferin’s anti-inflammatory activity and its potential role in wound healing, supporting the inflammatory and dermatological portions of the claim. The Results report antibacterial activity for mango peel extract, not mangiferin alone. The paper does not establish protective effects of mangiferin in neurodegenerative, ocular, renal, or cardiovascular diseases. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Espinosa-Espinosa, L., Garduño-Siciliano, L., Rodriguez-Canales, M., Hernandez-Portilla, L. B., Canales-Martinez, M. M., & Rodriguez-Monroy, M. A.
Affiliations
  • Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala (MX)
  • Laboratorio de Toxicología de Productos Naturales, Escuela Nacional de Ciencias Biológicas, IPN, U. Prof. Adolfo López Mateos, Mexico City C.P. 07738, Mexico
  • Laboratorio Nacional en Salud, Facultad de Estudios Superiores Iztacala UNAM, Tlalnepantla C.P. 54090, Mexico
  • Laboratorio de Farmacognosia, UBIPRO Facultad de Estudios Superiores Iztacala UNAM, Tlalnepantla C.P. 54090, Mexico
  • Laboratorio de Investigación Biomédica de Productos Naturales, Facultad de Estudios Superiores Iztacala, UNAM, Tlalnepantla C.P. 54090, Mexico
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2022-01-01
Volume
27
Issue
1
Pages
259
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules27010259
PMC
PMC8746551
OpenAlex
W4205971938
Cited by
39
References
3
Citations by year
2026: 9 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 2
FWCI
7.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Universidad Nacional Autónoma de México, Dirección General de Asuntos del Personal Académico (DGAPA-PAPIIT-UNAM [IN204821], DGAPA-PAPIIT-UNAM [IN205020])
  • Secretaría de Investigación y Posgrado of the Instituto Politécnico Nacional ([SIP-IPN Project No. 20201470])
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
Keywords
mango peel extract, mango, wound healing, incision wound, mangiferin, flavonoids, antioxidant activity, anti-inflammatory activity, antibacterial activity, Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli, acute skin toxicity, wound contraction, tensile strength, resorcinol, total phenolic content, total flavonoid content
MeSH terms
Animals, Disease Models, Animal, Flavonoids, Male, Plant Extracts, Wound Healing, Wounds and Injuries, Mangifera, Xanthones, Mice

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