The DOI matches its Crossref record; 325 of the 325 references it cites were found in a registry or an index.
Natural Products as Anticancer Agents: Current Status and Future Perspectives
Open accessAbstract
Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds have been synthesized from natural products by modifying their structures or by using naturally occurring compounds as building blocks in the synthesis of these compounds for various purposes in different fields, such as biology, medicine, and engineering. Multiple modern and costly treatments have been applied to combat cancer and limit its lethality, but the results are not significantly refreshing. Natural products, which are a significant source of new therapeutic drugs, are currently being investigated as potential cytotoxic agents and have shown a positive trend in preclinical research and have prompted numerous innovative strategies in order to combat cancer and expedite the clinical research. Natural products are becoming increasingly important for drug discovery due to their high molecular diversity and novel biofunctionality. Furthermore, natural products can provide superior efficacy and safety due to their unique molecular properties. The objective of the current review is to provide an overview of the emergence of natural products for the treatment and prevention of cancer, such as chemosensitizers, immunotherapeutics, combinatorial therapies with other anticancer drugs, novel formulations of natural products, and the molecular mechanisms underlying their anticancer properties.
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Cites
6 retracted
Zhang, P., Lai, Z., Chen, H., Zhang, M., Wang, A., Jia, T., Sun, W., Zhu, X., Chen, X., Zhao, Z., et al. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0661-7 · Cited by 106
Self-citationRetractedFu, H., Li, C., Chen, X., & Liu, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3531 · Cited by 95
RetractedXu, F., Li, Q., Wang, Z., & Cao, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.053 · Cited by 77
RetractedMousa, D. S., El‐Far, A. H., Saddiq, A. A., Sudha, T., & Mousa, S. A. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s238256 · Cited by 42
RetractedRETRACTED ARTICLE: Anti-gastric cancer effect of Salidroside through elevating miR-99a expression
Yang, L., Yu, Y., Zhang, Q., Li, X., Zhang, C., Mao, T., Liu, S., & Tian, Z. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1652626 · Cited by 19
RetractedYu, X., Wang, Y., Tao, S., & Sun, S. (2019) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2019.104349 · Cited by 16
RetractedSung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
Newman, D. J., & Cragg, G. M. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b01285 · Cited by 7,015
Natural products as sources of new drugs from 1981 to 2014
Newman, D. J., & Cragg, G. M. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b01055 · Cited by 5,858
Cited by
Tanaka, M., Araujo, A. C., Valenti, V. E., Guiguer, E. L., Catharin, V. C. S., Gualhardi, C. M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R. S., de Carvalho, A. C. A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052370 · Cited by 13
Lakshmanan, J., Jaganathan, V. L., Zhang, B., Werner, G., Allen, T. S., Schultz, D. J., Klinge, C. M., & Harbrecht, B. G. (2025) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/0118715206327789241008162423 · Cited by 5
Metadata
- Authors
- Naeem, A., Hu, P., Yang, M., Zhang, J., Liu, Y., Zhu, W., & Zheng, Q.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2022-11-30
- Volume
- 27
- Issue
- 23
- Pages
- 8367
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W4311051500
- Cited by
- 607
- References
- 325
- FWCI
- 29.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Naeem, A., Hu, P., Yang, M., Zhang, J., Liu, Y., Zhu, W., & Zheng, Q. (2022). Natural Products as Anticancer Agents: Current Status and Future Perspectives. Molecules. https://doi.org/10.3390/molecules27238367
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
