The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development
Open accessAbstract
MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene transcripts’ expression. miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors. In the present review, we have focused on the recent acquisitions about the key role played by miR-146a, miR-146b and miR-155 in the control of the immune system and in myeloid tumorigenesis. Growing experimental evidence indicates an opposite role of miR-146a with respect to miR-155 in the fine regulation of many steps of the immune response, acting at the level of the various cell types involved in innate and adaptive immune mechanisms. The demonstration that miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy.
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Cites
1 retracted
SHIP1 is targeted by miR-155 in acute myeloid leukemia
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RetractedPattern Recognition Receptors and Inflammation
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MicroRNA-155 is induced during the macrophage inflammatory response
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Requirement of bic/microRNA-155 for Normal Immune Function
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Cited by
miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis
Tavasolian, F., Hosseini, A. Z., Soudi, S., & Naderi, M. (2020) · Current Gene Therapy · doi:10.2174/1566523220666200916120708 · Cited by 125
Gut Microbiota and Autism Spectrum Disorder: A Neuroinflammatory Mediated Mechanism of Pathogenesis?
Zarimeidani, F., Rahmati, R., Mostafavi, M., Darvishi, M., Khodadadi, S., Mohammadi, M., Shamlou, F., Bakhtiyari, S., & Alipourfard, I. (2024) · Inflammation · doi:10.1007/s10753-024-02061-y · Cited by 47
Consequences of genetic variants in miRNA genes
Machowska, M., Galka-Marciniak, P., & Kozlowski, P. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.11.036 · Cited by 40
Engel, A., Wagner, V., Hahn, O., Foltz, A. G., Atkins, M., Beganovic, A., Guldner, I. H., Lu, N., Saksena, A., Fischer, U., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59860-6 · Cited by 18
Metadata
- Authors
- Testa, U., Pelosi, E., Castelli, G., & Labbaye, C.
- Venue
- Non-Coding RNA
- Publisher
- MDPI AG
- Published
- 2017-06-26
- Volume
- 3
- Issue
- 3
- Pages
- 22
- ISSN
- 2311-553X (ISSN-L)
- OpenAlex
- W2710560069
- Cited by
- 267
- References
- 112
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- gold
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