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Extracellular Water to Total Body Water Ratio in Viral Liver Diseases: A Study Using Bioimpedance Analysis

Nishikawa, Hiroki, Yoh, Kazunori, Enomoto, Hirayuki, Ishii, Noriko, Iwata, Yoshinori, Nakano, Chikage, Takata, Ryo, Nishimura, Takashi, Aizawa, Nobuhiro, Sakai, Yoshiyuki, Ikeda, Naoto, Hasegawa, Kunihiro, Takashima, Tomoyuki, Iijima, Hiroko, Nishiguchi, Shuhei·2018·Nutrients
DOI 10.3390/nu10081072
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Abstract

Aims: To investigate the relationship between extracellular water to total body water ratio (ECW/TBW) in bioimpedance analysis (BIA) and clinical parameters in hepatitis viruses related to liver diseases. Methods: ECW/TBW was compared in patients with hepatitis B virus (HBV, n = 85) and hepatitis C virus (HCV, n = 440) related liver diseases. We also examined factors linked to mild to severe overhydrated state (ECW/TBW ≥0.4). Results: The median ECW/TBW in the HCV group was 0.388 (range, 0.365–0.433), while that in the HBV group was 0.381 (range, 0.363–0.425) (p < 0.0001). In all cases (n = 525), for predicting F3 or more, ECW/TBW yielded the area under the receiver operating characteristics (AUROC, 0.74912) and for predicting F4, ECW/TBW yielded the AUROC (0.75517). Multivariate analysis showed that age, prothrombin time, serum albumin, and alanine aminotransferase were significant factors linked to ECW/TBW ≥0.4. In patients with FIB-4 index <2, ECW/TBW in the HCV group was significantly higher than that in the HBV group (p = 0.0188), while in patients with 2 ≤ FIB-4 index <4 and FIB-4 index ≥4, the difference in the two groups did not reach significance. Conclusion: ECW/TBW can be different according to hepatitis viruses. Overhydrated status can easily occur in the HCV group even in the non-LC status compared with the HBV group.

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Metadata

Authors
Nishikawa, H., Yoh, K., Enomoto, H., Ishii, N., Iwata, Y., Nakano, C., Takata, R., Nishimura, T., Aizawa, N., Sakai, Y., Ikeda, N., Hasegawa, K., Takashima, T., Iijima, H., & Nishiguchi, S.
Venue
Nutrients
Publisher
MDPI AG
Published
2018-08-12
Volume
10
Issue
8
Pages
1072
ISSN
2072-6643
DOI
10.3390/nu10081072
Cited by
61
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: Extracellular Water to Total Body Water Ratio in Viral Liver Diseases: A Study Using Bioimpedance Analysis. https://app.cochat.ai/papers/10.3390/nu10081072
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Nishikawa, H., Yoh, K., Enomoto, H., Ishii, N., Iwata, Y., Nakano, C., Takata, R., Nishimura, T., Aizawa, N., Sakai, Y., Ikeda, N., Hasegawa, K., Takashima, T., Iijima, H., & Nishiguchi, S. (2018). Extracellular Water to Total Body Water Ratio in Viral Liver Diseases: A Study Using Bioimpedance Analysis. Nutrients. https://doi.org/10.3390/nu10081072

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