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Cited by 78Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance

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Cӑtoi, Adriana Florinela, Pârvu, Alina Elena, Andreicuț, Andra Diana, Mironiuc, Aurel, Crӑciun, Alexandra, Cӑtoi, Cornel, Pop, Ioana Delia·2018·Nutrients
DOI 10.3390/nu10091199PMC PMC6164113
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Abstract

Metabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metabolically unhealthy morbidly obese (MUHMO) with metabolic syndrome (MS) and to identify the potential predictors of MS in the MHMO group. Two groups of MHMO and MUHMO with MS were analysed. We evaluated serum high sensitivity C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), chemerin, nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), fasting blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR.) MHMO have similar hsCRP and TNF-α values as the MUHMO with MS, while chemerin was significantly lower in MHMO. NOx was higher in MUHMO with MS patients, while no difference regarding TOS and TAR was found between the two groups. HOMA-IR and insulin values were lower in MHMO as compared to the MUHMO with MS group. Insulin, HOMA-IR, and chemerin were identified predictors of MS in MHMO. In conclusion, MHMO and MUHMO display similarities and differences in terms of chronic inflammation, nitro-oxidative stress, and IR. Markers of IR and chemerin are possible predictors of MS in MHMO.

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  • Even though individuals in the present study were obese, given their normal glucose and lipid metabolism, their obesity may be considered as metabolically healthy that may not considerably affect the results.

    “Even though individuals in the present study were obese, given their normal glucose (even after a glucose load) and lipid metabolism, their obesity may be considered as metabolically healthy that may not considerably affect the results [16].”

    From Optimal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Cut-Offs: A Cross-Sectional Study in the Czech Population (2019) · cites this paper as [16]

    The Introduction defines metabolically healthy obesity as obesity without metabolic disturbances, and Methods §2.3 uses normal fasting glucose and lipid-related measures among its criteria. But the paper does not establish that the citing study’s participants meet its criteria—particularly on the basis of a glucose-load result—or that their obesity would not considerably affect that study’s results. The Introduction also cautions that metabolically healthy obesity can still carry health risks. (LLM, conf=0.88)

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Authors
Cӑtoi, A. F., Pârvu, A. E., Andreicuț, A. D., Mironiuc, A., Crӑciun, A., Cӑtoi, C., & Pop, I. D.
Affiliations
  • Department of Pathophysiology, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
  • Iuliu Hațieganu University of Medicine and Pharmacy (RO)
  • Department of Biochemistry, Faculty of Medicine, ‘Iuliu Hațieganu’, University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
  • Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca 400012, Romania
  • University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca (RO)
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2018-09-01
Volume
10
Issue
9
Pages
1199
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu10091199
PMC
PMC6164113
OpenAlex
W2889235433
Cited by
78
References
4
Citations by year
2026: 2 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 14 · 2021: 17 · 2020: 11 · 2019: 7 · 2018: 1
FWCI
7.03
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania (27020/39/15.11.2011)
  • European Social Fund, Human Resources Development Operational Programme 2007-2013 (POSDRU/159/1.5/S/138776)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
metabolically healthy obesity, morbid obesity, metabolic syndrome, chronic inflammation, nitro-oxidative stress, insulin resistance, chemerin, C-reactive protein, TNF-α, nitric oxide, antioxidant status, HOMA-IR, insulin
MeSH terms
Obesity, Metabolically Benign, Nitrosative Stress, Adult, Blood Glucose, Female, Humans, Inflammation, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Morbid, Predictive Value of Tests, Retrospective Studies, Risk Factors, Biomarkers, Oxidative Stress, Inflammation Mediators, Chemokines, Metabolic Syndrome, Intercellular Signaling Peptides and Proteins

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