Cited by 90Nitric Oxide and Endothelin EffectsDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies

Open access
Das, Diptimayee, Shruthi, Nagainallur Ravichandran, Banerjee, Antara, Jothimani, Ganesan, Duttaroy, Asim K., Pathak, Surajit·2023·Frontiers in Nutrition

Abstract

Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension, dyslipidemia, hyperglycemia, endothelial dysfunction, and platelet hyperactivity. There is a concerning rise in the occurrence and frequency of MetS globally. The rising incidence and severity of MetS need a proactive, multipronged strategy for identifying and treating those affected. For many MetS patients, achieving recommended goals for healthy fat intake, blood pressure control, and blood glucose management may require a combination of medicine therapy, lifestyles, nutraceuticals, and others. However, it is essential to note that lifestyle modification should be the first-line therapy for MetS. In addition, MetS requires pharmacological, nutraceutical, or other interventions. This review aimed to bring together the etiology, molecular mechanisms, and dietary strategies to combat hypertension, endothelial dysfunction, and platelet dysfunction in individuals with MetS.

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Crossref · 10.3389/fnut.2023.1221438

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  • Hyperglycaemia, insulin resistance and chronic inflammation promote the formation of ROS, which scavenge NO and impair eNOS activity.

    “Hyperglycaemia, insulin resistance and chronic inflammation promote the formation of ROS, which scavenge NO and impair eNOS activity.”

    From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [205]

    The Molecular mechanisms section links elevated blood sugar in type 2 diabetes to increased ROS and eNOS loss, and says inflammation can increase mitochondrial ROS. Pharmacotherapy describes nitric oxide breakdown through interaction with superoxide and eNOS uncoupling. But the Introduction describes ROS-related oxidative stress as contributing to insulin resistance, not insulin resistance as promoting ROS formation; the claim reverses that part of the relationship. The indexed passages provide section labels but no page numbers. (LLM, conf=0.85)

    Experimental — accuracy not yet measured
  • This accelerates vascular damage and atherogenesis.

    “This accelerates vascular damage and atherogenesis [205,206].”

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Authors
Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S.
Affiliations
  • Chettinad Academy of Research and Education (IN)
  • University of Oslo (NO)
Corresponding author
  • Duttaroy, Asim K.
  • Pathak, Surajit
Venue
Frontiers in Nutrition
Published
2023-08-08
Volume
10
Pages
1221438-1221438
ISSN
2296-861X (ISSN-L)
OpenAlex
W4385663817
Cited by
90
References
262
Citations by year
2026: 30 · 2025: 39 · 2024: 21
FWCI
3.21
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
Funders
  • Universitetet i Oslo
  • Chettinad Academy of Research and Education
  • Medisinske fakultet, Universitetet i Oslo
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
metabolic syndrome, endothelial dysfunction, platelet hyperreactivity, hypertension, obesity, dyslipidemia, hyperglycemia, atherosclerotic cardiovascular disease, molecular mechanisms, lifestyle modification, nutraceuticals, nutritional strategies, blood pressure control, glucose management

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