Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies
Open accessAbstract
Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension, dyslipidemia, hyperglycemia, endothelial dysfunction, and platelet hyperactivity. There is a concerning rise in the occurrence and frequency of MetS globally. The rising incidence and severity of MetS need a proactive, multipronged strategy for identifying and treating those affected. For many MetS patients, achieving recommended goals for healthy fat intake, blood pressure control, and blood glucose management may require a combination of medicine therapy, lifestyles, nutraceuticals, and others. However, it is essential to note that lifestyle modification should be the first-line therapy for MetS. In addition, MetS requires pharmacological, nutraceutical, or other interventions. This review aimed to bring together the etiology, molecular mechanisms, and dietary strategies to combat hypertension, endothelial dysfunction, and platelet dysfunction in individuals with MetS.
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Hyperglycaemia, insulin resistance and chronic inflammation promote the formation of ROS, which scavenge NO and impair eNOS activity.
“Hyperglycaemia, insulin resistance and chronic inflammation promote the formation of ROS, which scavenge NO and impair eNOS activity.”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [205]
The Molecular mechanisms section links elevated blood sugar in type 2 diabetes to increased ROS and eNOS loss, and says inflammation can increase mitochondrial ROS. Pharmacotherapy describes nitric oxide breakdown through interaction with superoxide and eNOS uncoupling. But the Introduction describes ROS-related oxidative stress as contributing to insulin resistance, not insulin resistance as promoting ROS formation; the claim reverses that part of the relationship. The indexed passages provide section labels but no page numbers. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThis accelerates vascular damage and atherogenesis.
“This accelerates vascular damage and atherogenesis [205,206].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [205]
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- Authors
- Das, D., Shruthi, N. R., Banerjee, A., Jothimani, G., Duttaroy, A. K., & Pathak, S.
- Affiliations
- Chettinad Academy of Research and Education (IN)
- University of Oslo (NO)
- Corresponding author
- Duttaroy, Asim K.
- Pathak, Surajit
- Venue
- Frontiers in Nutrition
- Publisher
- Frontiers Media SA
- Published
- 2023-08-08
- Volume
- 10
- Pages
- 1221438-1221438
- ISSN
- 2296-861X (ISSN-L)
- PMC
- PMC10442661
- OpenAlex
- W4385663817
- Cited by
- 90
- References
- 262
- Citations by year
- 2026: 30 · 2025: 39 · 2024: 21
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Nutrition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- Universitetet i Oslo
- Chettinad Academy of Research and Education
- Medisinske fakultet, Universitetet i Oslo
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- metabolic syndrome, endothelial dysfunction, platelet hyperreactivity, hypertension, obesity, dyslipidemia, hyperglycemia, atherosclerotic cardiovascular disease, molecular mechanisms, lifestyle modification, nutraceuticals, nutritional strategies, blood pressure control, glucose management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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