Anti-Photoaging Effects of Four Insect Extracts by Downregulating Matrix Metalloproteinase Expression via Mitogen-Activated Protein Kinase-Dependent Signaling
Open accessAbstract
Insects are some of the most diverse organisms on the planet, and have potential value as food or medicine. Here, we investigated the photoprotective properties of insect extracts using hairless mice. The alleviating wrinkle formation effects of insect extracts were evaluated by histological skin analysis to determine epidermal thickness and identify collagen fiber damage. Moreover, we investigated the ability of the insect extracts to alleviate UVB-induced changes to matrix metalloproteinases (MMPs), oxidative damage, the mitogen-activated protein kinases (MAPKs) signaling pathway, and the expression of pro-inflammatory cytokines. Insect extracts reduced UVB-induced skin winkles, epidermal thickening, and collagen breakdown, and alleviated the epidermal barrier dysfunction induced by UVB, including the increased loss of transepidermal water. Moreover, the expression of skin hydration-related markers such as hyaluronic acid, transforming growth factor-beta (TGF-β), and procollagen was upregulated in the group treated with insect extracts compared to the vehicle-treated group after ultraviolet B (UVB) exposure. UVB irradiation also upregulated the expression of MMPs, the phosphorylation of MAPKs, and pro-inflammatory cytokines, which were all attenuated by the oral administration of insect extracts. These results indicate the photoaging protection effect of insect extracts and the underlying mechanism, demonstrating the potential for clinical development.
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Level of skin hydration-related markers including HA, TGF-beta, and procollagen was upregulated markedly through treatment with insect extracts after UVB exposure.
“Furthermore, the level of skin hydration-related markers including HA, TGF-β, and procollagen was upregulated markedly through treatment with insect extracts after UVB exposure [137].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [137]
Oral supplementation with four insect extracts relieved skin wrinkles, epidermal thickening, barrier dysfunction, loss of transepidermal water, and collagen breakdown and inhibited expression of MMPs, phosphorylation of MAPK, and relief of pro-inflammatory cytokines.
“Oral supplementation with four insect extracts including Allomyrina dichotoma larva, Protaetia brevitarsis seulensis, Tenebrio molitor Linnaeus, and Gryllus bimaculatus De Geer relieved skin winkles, epidermal thickening, barrier dysfunction, loss of transepidermal water, and collagen breakdown and inhibited the expression of MMPs, phosphorylation of MAPK, and relief of pro-inflammatory cytokines.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [137]
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References 37 · Cited by 18
- Authors
- Im, A.-R., Ji, K.-Y., Park, I., Lee, J. Y., Kim, K. M., Na, M., & Chae, S.
- Affiliations
- Korea Institute of Oriental Medicine (KR)
- Chungnam National University (KR)
- Corresponding author
- Na, MinKyun
- Chae, Sungwook
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-05-23
- Volume
- 11
- Issue
- 5
- Pages
- 1159
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6566685
- OpenAlex
- W2945292285
- Cited by
- 18
- References
- 37
- Citations by year
- 2026: 3 · 2024: 5 · 2023: 2 · 2021: 5 · 2020: 2 · 2019: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- insect extracts, photoaging, UVB-induced skin damage, matrix metalloproteinases, MAPK signaling, inflammatory cytokines, skin barrier dysfunction, transepidermal water loss, collagen degradation, hyaluronic acid, TGF-beta, procollagen, photoprotection, oral administration
- MeSH terms
- Animals, Coleoptera, Collagen, Gryllidae, Mice, Hairless, Skin, Tenebrio, Tissue Extracts, Ultraviolet Rays, Water Loss, Insensible, Signal Transduction, Down-Regulation, Skin Aging, Cytokines, Matrix Metalloproteinase 9, Mitogen-Activated Protein Kinases, Matrix Metalloproteinase 13
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