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Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review
Open accessAbstract
Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative stress. Oxidative stress is present even in the early stages of CKD, progresses parallelly with the deterioration of kidney function, and is even more exacerbated in end-stage renal disease patients undergoing maintenance hemodialysis. Although acting in the plasma as an antioxidant, once uric acid enters the intracellular environment; it behaves as a powerful pro-oxidant. Exogenous intake of antioxidants has been repeatedly shown to prevent inflammation, atherosclerosis and oxidative stress in CKD patients. Moreover, certain antioxidants have been proposed to exert uric acid-lowering properties. This review aims to present the available data regarding the effects of antioxidant supplements on both oxidative stress and uric acid serum levels, in a population particularly susceptible to oxidative damage such as CKD patients.
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“Accordingly, chronic serum hyperuricemia positively correlates with inflammation, DNA damage and OS, and has been implicated in the pathogenesis of several disorders, including renal, metabolic, and cardiovascular diseases [214,217,218].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [214]
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“In the context of OS, although UA is classified as an important antioxidant molecule when circulating in the plasma, it exerts a potent pro-oxidant activity once inside the cell or in the form of extracellular crystals, probably due to different environmental interactions [214,215].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [214]
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Metadata
- Authors
- Roumeliotis, S., Roumeliotis, A., Dounousi, E., Eleftheriadis, T., & Liakopoulos, V.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- University of Ioannina (GR)
- University of Thessaly (GR)
- Corresponding author
- Liakopoulos, Vassilios
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-08-15
- Volume
- 11
- Issue
- 8
- Pages
- 1911
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6723425
- OpenAlex
- W2967734709
- Cited by
- 149
- References
- 129
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 27 · 2023: 19 · 2022: 19 · 2021: 19 · 2020: 23 · 2019: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Keywords
- uric acid, chronic kidney disease, oxidative stress, inflammation, end-stage renal disease, hemodialysis, cardiovascular disease, mortality
- MeSH terms
- Antioxidants, Humans, Kidney, Uric Acid, Biomarkers, Up-Regulation, Treatment Outcome, Oxidative Stress, Dietary Supplements, Hyperuricemia, Renal Insufficiency, Chronic
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