Cited by 149Gout, Hyperuricemia, Uric AcidAntioxidant Activity and Oxidative StressDialysis and Renal Disease Management

The DOI matches its Crossref record; 128 of the 129 references it cites were found in a registry or an index.

Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review

Open access

Roumeliotis, Stefanos, Roumeliotis, Athanasios, Dounousi, Evangelia, Eleftheriadis, Theodoros, Liakopoulos, Vassilios·2019·Nutrients

DOI 10.3390/nu11081911PMC PMC6723425

Open this paper in CoChat — free account Open PDF

Abstract

Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative stress. Oxidative stress is present even in the early stages of CKD, progresses parallelly with the deterioration of kidney function, and is even more exacerbated in end-stage renal disease patients undergoing maintenance hemodialysis. Although acting in the plasma as an antioxidant, once uric acid enters the intracellular environment; it behaves as a powerful pro-oxidant. Exogenous intake of antioxidants has been repeatedly shown to prevent inflammation, atherosclerosis and oxidative stress in CKD patients. Moreover, certain antioxidants have been proposed to exert uric acid-lowering properties. This review aims to present the available data regarding the effects of antioxidant supplements on both oxidative stress and uric acid serum levels, in a population particularly susceptible to oxidative damage such as CKD patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/nu11081911

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.
Ames, B. N., Cathcart, R., Schwiers, E., & Hochstein, P. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6858 · Cited by 2,915
A Role for Uric Acid in the Progression of Renal Disease
Kang, D., Nakagawa, T., Feng, L., Watanabe, S., Han, L., Mazzali, M., Truong, L. D., Harris, R. C., & Johnson, R. J. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000034910.58454.fd · Cited by 1,306
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Mazzali, M., Hughes, J., Kim, Y.-G., Jefferson, J. A., Kang, D., GORDON, K. L., Lan, H. Y., Kivlighn, S. D., & Johnson, R. J. (2001) · Hypertension · doi:10.1161/hy1101.092839 · Cited by 1,298
Structure−Activity Relationship and Classification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers
Cos, P., Li, Y., Calomme, M. R., Hu, J., Cimanga, K., Poel, B. V., Pieters, L. A. C., Vlietinck, A. J., & Berghe, D. V. (1998) · Journal of Natural Products · doi:10.1021/np970237h · Cited by 1,092
Uric Acid: The Oxidant-Antioxidant Paradox
Sautin, Y. Y., & Johnson, R. J. (2008) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770802138558 · Cited by 1,029
Uric Acid–Induced C-Reactive Protein Expression
Kang, D., Park, S. K., Lee, I., & Johnson, R. J. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005050572 · Cited by 881
Towards the physiological function of uric acid
Becker, B. F. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90143-i · Cited by 838
Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin–angiotensin system
Corry, D. B., Eslami, P., Yamamoto, K., Nyby, M. D., Makino, H., & Tuck, M. L. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f240bf · Cited by 750
Mechanisms by Which Dehydration May Lead to Chronic Kidney Disease
Roncal-Jiménez, C. A., Lanaspa, M. A., Jensen, T., Sánchez‐Lozada, L. G., & Johnson, R. J. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000381239 · Cited by 696
Uric acid and chronic kidney disease: which is chasing which?
Johnson, R. J., Nakagawa, T., Jalal, D. I., Sánchez‐Lozada, L. G., Kang, D., & Ritz, E. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft029 · Cited by 678
Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: A 28‐week, phase III, randomized, double‐blind, parallel‐group trial
Schumacher, H. R., Becker, M. A., Wortmann, R. L., MacDonald, P. A., Hunt, B., Streit, J., Lademacher, C., & Joseph‐Ridge, N. (2008) · Arthritis Care & Research · doi:10.1002/art.24209 · Cited by 638
Oxidative Stress with an Activation of the Renin-Angiotensin System in Human Vascular Endothelial Cells as a Novel Mechanism of Uric Acid-Induced Endothelial Dysfunction
Yu, M.-A., Sánchez-Lozada, L. G., Johnson, R. J., & Kang, D.-H. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328337da1d · Cited by 626
Effects of Xanthine Oxidase Inhibition With Allopurinol on Endothelial Function and Peripheral Blood Flow in Hyperuricemic Patients With Chronic Heart Failure
Doehner, W., Schoene, N., Rauchhaus, M., Leyva‐Leon, F., Pavitt, D. V., Reaveley, D. A., Schuler, G. C., Coats, A. J. S., Anker, S. D., & Hambrecht, R. (2002) · Circulation · doi:10.1161/01.cir.0000017502.58595.ed · Cited by 565
Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats
Sánchez‐Lozada, L. G., Tapia, E., Santamaría, J., Ávila-Casado, C., Soto, V., Nepomuceno‐Mejía, T., Rodríguez‐Iturbe, B., Johnson, R. J., & Herrera-Acosta, J. (2004) · Kidney International · doi:10.1111/j.1523-1755.2005.00074.x · Cited by 550
New developments and novel therapeutic perspectives for vitamin C
Li, Y., & Schellhorn, H. E. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.10.2171 · Cited by 508
Antioxidant Effects of Tea: Evidence from Human Clinical Trials
Rietveld, A. G., & Wiseman, S. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3285s · Cited by 501
Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension
Butler, R., Morris, A. D., Belch, J. J. F., Hill, A., & Struthers, A. D. (2000) · Hypertension · doi:10.1161/01.hyp.35.3.746 · Cited by 463
Uric Acid and Long-term Outcomes in CKD
Madero, M., Sarnak, M. J., Wang, X., Greene, T., Beck, G. J., Kusek, J. W., Collins, A. J., Levey, A. S., & Menon, V. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.12.021 · Cited by 437
Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes
Asemi, Z., Zare, Z., Shakeri, H., Sabihi, S.-S., & Esmaillzadeh, A. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000349922 · Cited by 400
Induction of Oxidative Stress in Kidney
Özbek, E. (2012) · International Journal of Nephrology · doi:10.1155/2012/465897 · Cited by 388
Inhibition of Xanthine Oxidase by Flavonoids
Nagao, A., Michiko, S. E. K. I., & Kobayashi, H. (1999) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.63.1787 · Cited by 385
Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: a systematic review and meta-analysis based on observational cohort studies
Li, L., Chen, Y., Zhao, Y., Zeng, X., Liu, F., & Fu, P. (2014) · BMC Nephrology · doi:10.1186/1471-2369-15-122 · Cited by 371
Uric Acid-Induced Endothelial Dysfunction Is Associated with Mitochondrial Alterations and Decreased Intracellular ATP Concentrations
Sánchez‐Lozada, L. G., Lanaspa, M. A., Cristóbal-García, M., García‐Arroyo, F. E., Soto, V., Cruz‐Robles, D., Nakagawa, T., Yu, M. A., Kang, D., & Johnson, R. J. (2012) · Nephron Experimental Nephrology · doi:10.1159/000345509 · Cited by 340
High uric acid directly inhibits insulin signalling and induces insulin resistance
Zhu, Y., Hu, Y., Huang, T., Zhang, Y., Li, Z., Luo, C., Luo, Y., Yuan, H., Hisatome, I., Yamamoto, T., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.080 · Cited by 312
Cypermethrin-induced oxidative stress in rat brain and liver is prevented by Vitamin E or allopurinol
Giray, B., Gürbay, A., & Hıncal, F. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(00)00277-0 · Cited by 310
Systemic Uric Acid Administration Increases Serum Antioxidant Capacity in Healthy Volunteers
Waring, W. S., Webb, D. J., & Maxwell, S. R. J. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200109000-00005 · Cited by 291
Antioxidation mechanisms of uric acid
Simic, M. G., & Jovanović, S. V. (1989) · Journal of the American Chemical Society · doi:10.1021/ja00197a042 · Cited by 290
Uric Acid Oxidation by Peroxynitrite: Multiple Reactions, Free Radical Formation, and Amplification of Lipid Oxidation
Santos, C. X. C., Anjos, E. I., & Augusto, O. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1491 · Cited by 275
Essential Hypertension, Progressive Renal Disease, and Uric Acid
Johnson, R. J., Segal, M. S., Srinivas, T. R., Ejaz, A. A., Mu, W., Roncal, C., Sánchez‐Lozada, L. G., Gersch, M. S., Rodríguez‐Iturbe, B., Kang, D., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010063 · Cited by 275
Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function
Zoppini, G., Targher, G., Chonchol, M., Ortalda, V., Abaterusso, C., Pichiri, I., Negri, C., & Bonora, E. (2012) · Diabetes Care · doi:10.2337/dc11-1346 · Cited by 274
Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial
Panahi, Y., Kianpour, P., Mohtashami, R., Jafari, R., Simental‐Mendía, L. E., & Sahebkar, A. (2016) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000406 · Cited by 272
Hyperuricemia Causes Glomerular Hypertrophy in the Rat
Nakagawa, T., Mazzali, M., Kang, D., Kanellis, J., Watanabe, S., Sánchez‐Lozada, L. G., Rodríguez‐Iturbe, B., Herrera-Acosta, J., & Johnson, R. J. (2002) · American Journal of Nephrology · doi:10.1159/000066303 · Cited by 270
Serum urate as an antioxidant for ascorbic acid
Sevanian, A., Davies, K., & Hochstein, P. E. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1129s · Cited by 261
Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease
Ryu, E., Kim, M. J., Shin, H.-S., Jang, Y.-H., Choi, H. S., Jo, I., Johnson, R. J., & Kang, D. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00560.2012 · Cited by 258
Uric acid reduces exercise-induced oxidative stress in healthy adults
Waring, W. S., CONVERY, A., Mishra, V., Shenkin, A., Webb, D. J., & Maxwell, S. R. J. (2003) · Clinical Science · doi:10.1042/cs20030149 · Cited by 257
Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy
Syrjänen, J., Mustonen, J. T., & Pasternack, A. I. (2000) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/15.1.34 · Cited by 256
J-Shaped Mortality Relationship for Uric Acid in CKD
Suliman, M. E., Johnson, R. J., García‐López, E., Qureshi, A. R., Molinaei, H., Carrero, J. J., Heimbürger, O., Barany, P. F., Axelsson, J., Lindholm, B., et al. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2006.08.019 · Cited by 243
Uric Acid and Endothelial Dysfunction in Essential Hypertension
Zoccali, C., Maio, R., Mallamaci, F., Sesti, G., & Perticone, F. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005090949 · Cited by 240
Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey
Choi, H. K., & Curhan, G. C. (2007) · Arthritis Care & Research · doi:10.1002/art.22762 · Cited by 240
Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation
Wang, C., Pan, Y., Zhang, Q.-Y., Wang, F., & Kong, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038285 · Cited by 234
Pilot study of probiotic dietary supplementation for promoting healthy kidney function in patients with chronic kidney disease
Ranganathan, N., Ranganathan, P., Friedman, E. A., Joseph, A. J., Delano, B. G., Goldfarb, D. S., Tam, P. Y., Rao, A. V., Anteyi, E. A., & Musso, C. G. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0059-9 · Cited by 233
The treatment of hyperuricemia
Gliozzi, M., Malara, N., Muscoli, S., & Mollace, V. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.087 · Cited by 231
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: Implications for uncoupling endothelial nitric oxide synthase
Kuzkaya, N., Weißmann, N., Harrison, D. G., & Dikalov, S. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.009 · Cited by 225
Xanthine Oxidase Inhibition Reverses Endothelial Dysfunction in Heavy Smokers
Guthikonda, S., Sinkey, C., Barenz, T., & Haynes, W. G. (2003) · Circulation · doi:10.1161/01.cir.0000046448.26751.58 · Cited by 225
Uric Acid Induces Renal Inflammation via Activating Tubular NF-κB Signaling Pathway
Zhou, Y., Fang, L., Jiang, L., Wen, P., Cao, H., He, W., Dai, C., & Yang, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039738 · Cited by 223
High-Normal Serum Uric Acid Increases Risk of Early Progressive Renal Function Loss in Type 1 Diabetes
Ficociello, L., Rosolowsky, E. T., Niewczas, M. A., Maselli, N. J., Weinberg, J., Aschengrau, A., Eckfeldt, J. H., Stanton, R. C., Gałecki, A. T., Doria, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0227 · Cited by 218
Dietary Flavonoids as Xanthine Oxidase Inhibitors: Structure–Affinity and Structure–Activity Relationships
Lin, S., Zhang, G., Liao, Y., Pan, J., & Gong, D. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b03386 · Cited by 215
Serum Uric Acid as a Predictor for Development of Diabetic Nephropathy in Type 1 Diabetes
Hovind, P. H., Rossing, P. R., Tarnow, L., Johnson, R. J., & Parving, H. (2009) · Diabetes · doi:10.2337/db09-0014 · Cited by 215
Meal-Generated Oxidative Stress in Type 2 Diabetic Patients
Ceriello, A., Bortolotti, N., Motz, E., Crescentini, A., Lizzio, S., Russo, A., Tonutti, L., & Taboga, C. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1529 · Cited by 211 · cited 1×
“Therefore, dietary supplementation of Vitamin E could ameliorate meal-generated OS in these high-risk patients [68].”
Background
Peroxidase Properties of Extracellular Superoxide Dismutase
Hink, H. U., Santanam, N., Dikalov, S., McCann, L. A., Nguyen, A. D., Parthasarathy, S., Harrison, D. G., & Fukai, T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000027524.86752.02 · Cited by 201
The effects of vitamin C supplementation on serum concentrations of uric acid: Results of a randomized controlled trial
Huang, H., Appel, L. J., Choi, M. J., Gelber, A. C., Charleston, J. B., Norkus, E. P., & Miller, E. R. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21105 · Cited by 200
Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers
Waring, W. S., McKnight, J. A., Webb, D. J., & Maxwell, S. R. J. (2006) · Diabetes · doi:10.2337/db06-0283 · Cited by 200
Vitamin C Intake and the Risk of Gout in Men
Choi, H. K., Gao, X., & Curhan, G. C. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.606 · Cited by 193
Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver
Zhu, J. X., Wang, Y., Kong, L. D., Yang, C. L., & Zhang, X. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.03.037 · Cited by 186
Hypouricemic Action of Selected Flavonoids in Mice: Structure-Activity Relationships
Mo, S., Zhou, F. L., Lv, Y.-Z., Hu, Q., Zhang, D., & Kong, L. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1551 · Cited by 182
Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats
Renugadevi, J., & Prabu, S. M. (2009) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2009.06.006 · Cited by 171
Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study
Sturm, G., Kollerits, B., Neyer, U., Ritz, E., & Kronenberg, F. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.01.006 · Cited by 170
Protection Against Peroxynitrite-Dependent Tyrosine Nitration and α1-Antiproteinase Inactivation by Ascorbic Acid. A Comparison with other Biological Antioxidants
Whiteman, M., Halliwell, B. B., & Darley-Usmar, V. M. (1996) · Free Radical Research · doi:10.3109/10715769609149052 · Cited by 170
Serum Uric Acid and Renal Prognosis in Patients with IgA Nephropathy
Ohno, I., Hosoya, T., Gomi, H., Ichida, K., Okabe, H., & Hikita, M. (2001) · The Nephron journals/Nephron journals · doi:10.1159/000045939 · Cited by 169
Clinical Outcome of Hyperuricemia in IgA Nephropathy: A Retrospective Cohort Study and Randomized Controlled Trial
Shi, Y., Chen, W., Jalal, D. I., Li, Z., Chen, W., Mao, H., Yang, Q., Johnson, R. J., & Yu, X. (2011) · Kidney & Blood Pressure Research · doi:10.1159/000331453 · Cited by 166
High-Normal Serum Uric Acid Is Associated with Impaired Glomerular Filtration Rate in Nonproteinuric Patients with Type 1 Diabetes
Rosolowsky, E. T., Ficociello, L., Maselli, N. J., Niewczas, M. A., Binns, A. L., Roshan, B., Warram, J. H., & Królewski, A. S. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04271007 · Cited by 161
Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial
Shi, Y., & Williamson, G. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515005310 · Cited by 158
Randomized Controlled Trial of Strain-Specific Probiotic Formulation (Renadyl) in Dialysis Patients
Ranganathan, N., Pechenyak, B., Vyas, U., Ranganathan, P., Weinberg, A. D., Liang, P., Mallappallil, M. C., Norin, A. J., Friedman, E. A., & Saggi, S. J. (2014) · BioMed Research International · doi:10.1155/2014/568571 · Cited by 153
Uric acid: an important antioxidant in acute ischaemic stroke
Waring, W. S. (2002) · QJM · doi:10.1093/qjmed/95.10.691 · Cited by 145
Effect of oral vitamin C supplementation on serum uric acid: A meta‐analysis of randomized controlled trials
Juraschek, S. P., Miller, E. R., & Gelber, A. C. (2011) · Arthritis Care & Research · doi:10.1002/acr.20519 · Cited by 142
Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin
Pauff, J. M., & Hille, R. (2009) · Journal of Natural Products · doi:10.1021/np8007123 · Cited by 139
Effects of acute and chronic l -arginine treatment in experimental hyperuricemia
Sánchez‐Lozada, L. G., Tapia, E., López-Molina, R., Nepomuceno‐Mejía, T., Soto, V., Ávila-Casado, C., Nakagawa, T., Johnson, R. J., Herrera-Acosta, J., & Franco, M. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00164.2006 · Cited by 139
Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis).
Aucamp, J. P., Gaspar, A. R. M., Hara, Y., & Apostolides, Z. (1997) · PubMed · Cited by 133
Probiotic dietary supplementation in patients with stage 3 and 4 chronic kidney disease: a 6-month pilot scale trial in Canada
Ranganathan, N., Friedman, E. A., Tam, P. Y., Rao, V. G., Ranganathan, P., & Dheer, R. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903069249 · Cited by 133
Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice
Chen, G., Tan, M., Li, K.-K., Leung, P., & Ko, C. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.08.043 · Cited by 130
Oxidative stress in hemodialysis: Causative mechanisms, clinical implications, and possible therapeutic interventions
Liakopoulos, V., Roumeliotis, S. K., Zarogiannis, S. G., Eleftheriadis, T., & Mertens, P. R. (2018) · Seminars in Dialysis · doi:10.1111/sdi.12745 · Cited by 129
Self-citation
Ascorbic acid-induced uricosuria. A consequency of megavitamin therapy.
Stein, H., Hasan, A., & Fox, I. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-4-385 · Cited by 127
A study of the natural history of diabetic kidney disease (DKD)
Altemtam, N., Russell, J., & Nahas, M. E. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr561 · Cited by 123
Vitamin C intake and serum uric acid concentration in men.
Gao, X., Curhan, G. C., Forman, J. P., Ascherio, A., & Choi, H. K. (2008) · PubMed · Cited by 113
Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice
Huang, J., Wang, S., Zhu, M., Chen, J., & Zhu, X. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.04.029 · Cited by 108
Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males
Kiyohara, C., Kono, S., Honjo, S., Todoroki, I., Sakurai, Y., Nishiwaki, M., Hamada, H., Nishikawa, H., Koga, H., Ogawa, S., et al. (1999) · British Journal Of Nutrition · doi:10.1017/s0007114599001270 · Cited by 106
Characterisation of the antioxidant activity of flavonoids
Masuoka, N., Matsuda, M., & Kubo, I. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.09.020 · Cited by 105
Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver
Barja, G., Lopez‐Torres, M., Pérez‐Campo, R., Rojas, C., Cadenas, S., Prat, J., & Pamplona, R. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90108-2 · Cited by 103
The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion
Wang, S., Fang, Y., Yu, X., Guo, L., Zhang, X., & Xia, D. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.050 · Cited by 100
Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage
García‐Arroyo, F. E., Gonzaga, G., Muñoz-Jiménez, I., Blas-Marron, M. G., Silverio, O., Tapia, E., Soto, V., Ranganathan, N., Ranganathan, P., Vyas, U., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202901 · Cited by 94
Dietary Factors Associated with Hyperuricemia in Adults
Yu, K., See, L., Huang, Y., Yang, C.-H., & Sun, J. (2007) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2007.04.007 · Cited by 93
Evolution of Urate-Degrading Enzymes in Animal Peroxisomes
Hayashi, S., Fujiwara, S., & Noguchi, T. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:32:1-3:123 · Cited by 91
Effects of uric acid-lowering therapy in patients with chronic kidney disease: A meta-analysis
Su, X., Xu, B., Yan, B., Qiao, X., & Wang, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187550 · Cited by 91
An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia
Bove, M., Cicero, A. F. G., Veronesi, M., & Borghi, C. (2017) · Vascular Health and Risk Management · doi:10.2147/vhrm.s115080 · Cited by 90
Antioxidant Supplementation in Renal Replacement Therapy Patients: Is There Evidence?
Liakopoulos, V., Roumeliotis, S. K., Bozikas, A., Eleftheriadis, T., & Dounousi, E. C. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9109473 · Cited by 89
Self-citation
Clinically Insignificant Effect of Supplemental Vitamin C on Serum Urate in Patients With Gout: A Pilot Randomized Controlled Trial
Stamp, L. K., O'Donnell, J. L., FRAMPTON, C. M. A., Drake, J. M., Zhang, M., & Chapman, P. T. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37925 · Cited by 86
Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice
Hu, Q., Zhang, X., Wang, X., Jiao, R., & Kong, L. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0243-y · Cited by 86
The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid
Berger, L., Gerson, C. D., & Yű, T.-F. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90351-5 · Cited by 84
Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NJH3T3 cells
Lin, J., & Shih, C.-A. (1994) · Carcinogenesis · doi:10.1093/carcin/15.8.1717 · Cited by 83
Insights into the inhibition of xanthine oxidase by curcumin
Shen, L., & Ji, H. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.09.076 · Cited by 83
Effects of Local Curcumin on Oxidative Stress and Total Antioxidant Capacity in vivo Study
Al-Rubaei, Z. M. M., Mohammad, T. U., & Ali, L. K. (2014) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2014.1237.1241 · Cited by 80
Serum Antioxidant Activity in Uremic Patients
Kuroda, M., Asaka, S., Tofuku, Y., & Takeda, R. (2008) · The Nephron journals/Nephron journals · doi:10.1159/000183600 · Cited by 78
Characteristics and risk factors of intrarenal arterial lesions in patients with IgA nephropathy
Wu, J., Chen, X., Xie, Y., Yamanaka, N., Shi, S., Wu, D., Liu, S., & Cai, G. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh716 · Cited by 75
Effect of Urate-lowering Therapies on Renal Disease Progression in Patients with Hyperuricemia
Levy, G. D., Rashid, N., Niu, F., & Cheetham, T. C. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.131159 · Cited by 75
Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases
Bahorun, T., Luximon‐Ramma, A., Gunness, T. K., Sookar, D., Bhoyroo, S., Jugessur, R., Reebye, D., Googoolye, K., Crozier, A., & Aruoma, O. I. (2009) · Toxicology · doi:10.1016/j.tox.2009.11.024 · Cited by 72
Radical scavenging and xanthine oxidase inhibitory activity of phenolic compounds from Bridelia ferruginea stem bark
Cimanga, K., Li, Y., Bruyne, T. D., Apers, S., Cos, P., Hermans, N., Bakana, P., Tona, L., Kambu, K., Kalenda, D. T., et al. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011775893 · Cited by 68
Hyperuricemia is Associated With the Development of the Composite Outcomes of New Cardiovascular Events and Chronic Allograft Nephropathy
Akalin, E., Ganeshan, S. V., Winston, J. A., & Muntner, P. (2008) · Transplantation · doi:10.1097/tp.0b013e3181814f5b · Cited by 66
Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis
D’Arrigo, G., Baggetta, R., Tripepi, G. L., Galli, F., & Bolignano, D. (2016) · Blood Purification · doi:10.1159/000453444 · Cited by 65
Effect of apple polyphenols on vascular oxidative stress and endothelium function: a translational study
Cicero, A. F. G., Caliceti, C., Fogacci, F., Giovannini, M., Calabria, D., Colletti, A., Veronesi, M., Roda, A., & Borghi, C. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700373 · Cited by 63
Serum Urate Levels and Consumption of Common Beverages and Alcohol Among Chinese in Singapore
Teng, G. G., Tan, C. S., Santosa, A., Saag, K. G., Yuan, J., & Koh, W. (2013) · Arthritis Care & Research · doi:10.1002/acr.21999 · Cited by 59
Influence of vitamin C on markers of oxidative stress in the earliest period of ischemic stroke
Łagowska-Lenard, M., Stelmasiak, Z., & Bartosik-Psujek, H. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70334-0 · Cited by 59
Effects of Parsley (Petroselinum crispum) and its Flavonol Constituents, Kaempferol and Quercetin, on Serum Uric Acid Levels, Biomarkers of Oxidative Stress and Liver Xanthine Oxidoreductase Aactivity inOxonate-Induced Hyperuricemic Rats.
Haidari, F., Keshavarz, S. A., Shahi, M. M., Mahboob, S.-A., & Rashidi, M. (2011) · Europe PMC (PubMed Central) · Cited by 58
Combined Effects of Vitamin C, Vitamin E, and Sodium Selenate Supplementation on Absolute Ethanol-Induced Injury in Various Organs of Rats
Yanardağ, R., Saçan, Ö., Özdil, S., & Bolkent, Ş. (2007) · International Journal of Toxicology · doi:10.1080/10915810701707296 · Cited by 58
Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction
Russa, D. L., Giordano, F., Marrone, A., Parafati, M., Janda, E., & Pellegrino, D. (2019) · Antioxidants · doi:10.3390/antiox8030066 · Cited by 57
Uric Acid, Hypertension, and Cardiovascular and Renal Complications
Zoccali, C., & Mallamaci, F. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0391-y · Cited by 54
Comparison of Nutrient Intake and Diet Quality Between Hyperuricemia Subjects and Controls in Korea
Ryu, K.-A., Kang, H. H., Kim, S. Y., Yoo, M.-K., Kim, J. S., Lee, C. H., & Wie, G.-A. (2014) · Clinical Nutrition Research · doi:10.7762/cnr.2014.3.1.56 · Cited by 52
Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?
Russa, D. L., Pellegrino, D., Montesanto, A., Gigliotti, P., Perri, A., Russa, A. L., & Bonofiglio, R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8567275 · Cited by 52
The effect of coffee, tea, and caffeine consumption on serum uric acid and the risk of hyperuricemia in Korean Multi-Rural Communities Cohort
Bae, J., Park, P.-S., Chun, B.-Y., Choi, B. Y., Kim, M. K., Shin, M., Lee, Y. H., Shin, D. H., & Kim, S. (2014) · Rheumatology International · doi:10.1007/s00296-014-3061-8 · Cited by 45
Effect of large doses of ascorbic acid in man on some nitrogenous components of urine.
Sutton, J. L., Basu, T. K., & Dickerson, J. W. (1983) · PubMed · Cited by 39
Is tea consumption associated with the serum uric acid level, hyperuricemia or the risk of gout? A systematic review and meta-analysis
Zhang, Y., Cui, Y., Li, X.-A., Li, L., Xie, X., Huang, Y., Deng, Y., Zeng, C., & Lei, G. (2017) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-017-1456-x · Cited by 39
Determinants of plasma ascorbic acid in a healthy male population.
Sinha, R., Block, G., & Taylor, P. R. (1993) · PubMed · Cited by 38
Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction
Eleftheriadis, T., Pissas, G., Antoniadi, G., Liakopoulos, V., & Stefanidis, I. (2017) · International Urology and Nephrology · doi:10.1007/s11255-017-1733-5 · Cited by 35
Self-citation
Hypoxanthine induces oxidative stress in kidney of rats: protective effect of vitamins E plus C and allopurinol
Rodrigues, A. F., Roecker, R., Junges, G. M., de Lima, D. D., da Cruz, J. G. P., Wyse, Â. T. D. S., & Magro, D. D. D. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3029 · Cited by 34
Effect of Vitamin C Supplementation on C-reactive Protein Levels in Patients Undergoing Hemodialysis: A Randomized, Double Blind, Placebo-Controlled Study
Biniaz, V., Shermeh, M. S., Ebadi, A., Tayebi, A., & Einollahi, B. (2013) · Nephro-Urology Monthly · doi:10.5812/numonthly.13351 · Cited by 34
Olive leaf extract counteracts epithelial to mesenchymal transition process induced by peritoneal dialysis, through the inhibition of TGFβ1 signaling
Lupinacci, S., Perri, A., Toteda, G., Vizza, D., Puoci, F., Parisi, O. I., Giordano, F., Lofaro, D., Russa, A. L., Bonofiglio, M., et al. (2018) · Cell Biology and Toxicology · doi:10.1007/s10565-018-9438-9 · Cited by 34
Impaired L-Arginine Uptake But Not Arginase Contributes to Endothelial Dysfunction in Rats With Chronic Kidney Disease
Martens, C. R., Kuczmarski, J. M., Lennon, S. L., & Edwards, D. G. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000022 · Cited by 31
Oxidative imbalance and kidney damage in spontaneously hypertensive rats: activation of extrinsic apoptotic pathways
Russa, D. L., Brunelli, E., & Pellegrino, D. (2017) · Clinical Science · doi:10.1042/cs20170177 · Cited by 31
Effects of Green Tea Extract on Serum Uric Acid and Urate Clearance in Healthy Individuals
Jatuworapruk, K., Srichairatanakool, S., Ounjaijean, S., Kasitanon, N., Wangkaew, S., & Louthrenoo, W. (2014) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000148 · Cited by 29
Hemodynamics of hyperuricemia
Sánchez‐Lozada, L. G., Tapia, E., Rodríguez‐Iturbe, B., Johnson, R. J., & Herrera-Acosta, J. (2005) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.09.004 · Cited by 25
The effect of L-arginine on arterial stiffness and oxidative stress in chronic kidney disease
Annavarajula, S., Dakshinamurty, K., Naidu, M. U. R., & Reddy, C. P. (2012) · Indian Journal of Nephrology · doi:10.4103/0971-4065.103907 · Cited by 20
Effect of vitamin C supplementation on serum uric acid in patients undergoing hemodialysis: a randomized controlled trial.
Biniaz, V., Tayebi, A., Ebadi, A., Shermeh, M. S., & Einollahi, B. (2014) · Iranian Journal of Kidney Diseases · Cited by 20
Uric acid in chronic kidney disease: the quest for causality continues
Zoccali, C., & Mallamaci, F. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx341 · Cited by 20
THE INHIBITION OF XANTHINE OXIDASE IN VITRO BY TRACE AMOUNTS OF l-ASCORBIC ACID
Feigelson, P. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55640-4 · Cited by 19
Uric acid concentrations and the mechanisms of cardiovascular disease
Waring, W. S. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3343 · Cited by 14
Vitamin E as an Antioxidant Agent in CAPD Patients
Mydlík, M., Derzsiová, K., Rácz, O., Šipulová, A., Boldizsár, J., Lovásová, E., & Hríbiková, M. (2002) · The International Journal of Artificial Organs · doi:10.1177/039139880202500505 · Cited by 14
Extracellular Superoxide Dismutase, Uric Acid, and AtherosclerosisPreprint
Hink, H. U., & Fukai, T. (2002) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2002.67.483 · Cited by 11
Effect of vitamin E therapy on serum uric acid in DOCA-salt-treated rats
Seifi, B., Kadkhodaee, M., & Zahmatkesh, M. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.2.13 · Cited by 11
Dietary Flavonoid Quercetin Exhibits Uricosuric and Renal Protective Actions in Hyperuricemic Rodents: Renal Organic Ion Transporter Involvement
Kong, L., Qh, H., Zhang, X., Li, J., & Zhang, Q. (2012) · Planta Medica · doi:10.1055/s-0032-1307495 · Cited by 1

Flagged first, then by citations

1 of the 129 references couldn’t be matched to a known paper.

Sorted by citations

Uric Acid and Oxidative Stress—Relationship with Cardiovascular, Metabolic, and Renal Impairment
Gherghina, M.-E., Peride, I., Ţigliş, M., Neagu, T. P., Niculae, A., & Checheriţă, I. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063188 · Cited by 505
Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease
Podkowińska, A., & Formanowicz, D. (2020) · Antioxidants · doi:10.3390/antiox9080752 · Cited by 378
Research Advances in the Mechanisms of Hyperuricemia‐Induced Renal Injury
Su, H.-Y., Yang, C., Liang, D., & Liu, H.-F. (2020) · BioMed Research International · doi:10.1155/2020/5817348 · Cited by 232
Caffeine and Its Antioxidant Properties—It Is All about Dose and Source
Ősz, B.-E., Jîtcă, G., Ștefănescu, R., Puşcaş, A., Tero-Vescan, A., & Vari, C.-E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113074 · Cited by 155
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145

See all 149

Authors: Roumeliotis, S., Roumeliotis, A., Dounousi, E., Eleftheriadis, T., & Liakopoulos, V.
Affiliations: Aristotle University of Thessaloniki (GR)
University of Ioannina (GR)
University of Thessaly (GR)
Corresponding author: Liakopoulos, Vassilios
ORCID: Roumeliotis, Stefanos
Roumeliotis, Athanasios
Dounousi, Evangelia
Eleftheriadis, Theodoros
Liakopoulos, Vassilios
Venue: Nutrients
Publisher: MDPI AG
Published: 2019-08-15
Volume: 11
Issue: 8
Pages: 1911
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu11081911
PMC: PMC6723425
OpenAlex: W2967734709
Cited by: 149
References: 129
Citations by year: 2026: 14 · 2025: 26 · 2024: 27 · 2023: 19 · 2022: 19 · 2021: 19 · 2020: 23 · 2019: 2
FWCI: 2.46
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
Topics: Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords: uric acid, chronic kidney disease, oxidative stress, inflammation, end-stage renal disease, hemodialysis, cardiovascular disease, mortality
MeSH terms: Antioxidants, Humans, Kidney, Uric Acid, Biomarkers, Up-Regulation, Treatment Outcome, Oxidative Stress, Dietary Supplements, Hyperuricemia, Renal Insufficiency, Chronic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks