The DOI matches its Crossref record; 204 of the 205 references it cites were found in a registry or an index.
Caffeine as a factor influencing the functioning of the human body-friend or foe?
Open accessAbstract
Nowadays, caffeine is one of the most commonly consumed substances, which presents in many plants and products. It has both positive and negative effects on the human body, and its activity concerns a variety of systems including the central nervous system, immune system, digestive system, respiratory system, urinary tract, etc. These effects are dependent on quantity, the type of product in which caffeine is contained, and also on the individual differences among people (sex, age, diet etc.). The main aim of this review was to collect, present, and analyze the available information including the latest discoveries on the impact of caffeine on human health and the functioning of human body systems, taking into account the role of caffeine in individual disease entities. We present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson's disease, and others, not forgetting about the negative effects of excess caffeine (e.g., in people with hypertension, children, adolescents, and the elderly). In summary, we can conclude, however, that caffeine has a multi-directional influence on various organs of the human body, and because of its anti-oxidative properties, it was, and still is, an interesting topic for research studies including those aimed at developing new therapeutic strategies.
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“These fi ndings suggest the cut-off time for doses of caffeine contained in a standard cup of coffee or a standard serve of pre-workout supplement occur substantially earlier than anecdotally expected, and well before timings based on the typical half-life of three to six h [18,86,87].”
From The effect of caffeine on subsequent sleep: A systematic review and meta-analysis (2023) · cites this paper as [86]
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Flagged first, then by citations
1 of the 205 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
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The effect of caffeine on subsequent sleep: A systematic review and meta-analysis
Gardiner, C., Weakley, J., Burke, L. M., Roach, G. D., Sargent, C., Maniar, N., Townshend, A., & Halson, S. L. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101764 · Cited by 357
A review on the influence of nutraceuticals and functional foods on health
Vignesh, A., Amal, T. C., Sarvalingam, A., & Vasanth, K. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100749 · Cited by 249
Caffeine and Its Antioxidant Properties—It Is All about Dose and Source
Ősz, B.-E., Jîtcă, G., Ștefănescu, R., Puşcaş, A., Tero-Vescan, A., & Vari, C.-E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113074 · Cited by 155
The medicinal and aromatic plants as ingredients in functional beverage production
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Urugo, M. M., Tola, Y. B., Ogah, O., & Endale, F. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3848 · Cited by 142
Metadata
- Authors
- Rodak, K., Kokot, I., & Kratz, E. M.
- Affiliations
- Wroclaw Medical University (PL)
- Corresponding author
- Rodak, Kamil
- Kratz, Ewa Maria
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-09-02
- Volume
- 13
- Issue
- 9
- Pages
- 3088
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC8467199
- OpenAlex
- W3198497028
- Cited by
- 188
- References
- 205
- Citations by year
- 2026: 27 · 2025: 64 · 2024: 49 · 2023: 33 · 2022: 15
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Keywords
- caffeine, purine alkaloids, caffeine consumption, health effects of caffeine, central nervous system, immune system, digestive system, respiratory system, urinary tract, asthma, Parkinson's disease, hypertension, children and adolescents, older adults, antioxidant activity
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Analgesics, Animals, Antioxidants, Mental Disorders, Caffeine, Cardiovascular System, Child, Digestive System, Humans, Immune System, Respiratory System, Urinary Tract, Receptors, Purinergic P1, Neurodegenerative Diseases
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