Cited by 188Coffee research and impactsAlcohol Consumption and Health EffectsTea Polyphenols and Effects

The DOI matches its Crossref record; 204 of the 205 references it cites were found in a registry or an index.

Caffeine as a factor influencing the functioning of the human body-friend or foe?

Open access

Rodak, Kamil, Kokot, Izabela, Kratz, Ewa Maria·2021·Nutrients

Open this paper in CoChat — free account Open PDF

Abstract

Nowadays, caffeine is one of the most commonly consumed substances, which presents in many plants and products. It has both positive and negative effects on the human body, and its activity concerns a variety of systems including the central nervous system, immune system, digestive system, respiratory system, urinary tract, etc. These effects are dependent on quantity, the type of product in which caffeine is contained, and also on the individual differences among people (sex, age, diet etc.). The main aim of this review was to collect, present, and analyze the available information including the latest discoveries on the impact of caffeine on human health and the functioning of human body systems, taking into account the role of caffeine in individual disease entities. We present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson's disease, and others, not forgetting about the negative effects of excess caffeine (e.g., in people with hypertension, children, adolescents, and the elderly). In summary, we can conclude, however, that caffeine has a multi-directional influence on various organs of the human body, and because of its anti-oxidative properties, it was, and still is, an interesting topic for research studies including those aimed at developing new therapeutic strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/nu13093088

Cites

204 of 204 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
Association between Water Intake, Chronic Kidney Disease, and Cardiovascular Disease: A Cross-Sectional Analysis of NHANES Data
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903
Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199
Caffeine (1, 3, 7‐trimethylxanthine) in Foods: A Comprehensive Review on Consumption, Functionality, Safety, and Regulatory Matters
Heckman, M. A., Weil, J., & de Mejía, E. G. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01561.x · Cited by 1,116
Health effects of energy drinks on children, adolescents, and young adults
Seifert, S. M., Schaechter, J. L., Hershorin, E. R., & Lipshultz, S. E. (2011) · Pediatrics · doi:10.1542/peds.2009-3592 · Cited by 893
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Zuccato, C., Valenza, M., & Cattaneo, E. (2010) · Physiological Reviews · doi:10.1152/physrev.00041.2009 · Cited by 848
A Review of Caffeine’s Effects on Cognitive, Physical and Occupational Performance
McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.001 · Cited by 840
Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia
Ferré, S., Fuxé, K., Fredholm, B. B., Morelli, M., & Popoli, P. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01096-5 · Cited by 825
Adenosine in the central nervous system: release mechanisms and extracellular concentrations
Latini, S., & Pedata, F. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00607.x · Cited by 779
Association of coffee and caffeine intake with the risk of Parkinson disease
Ross, G. W. (2000) · JAMA · doi:10.1001/jama.283.20.2674 · Cited by 778
Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801262980403 · Cited by 757
Functional significance of a C–>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine
Sachse, C., Brockmöller, J., Bauer, S., & Roots, I. (1999) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1999.00898.x · Cited by 751
Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors
Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 632
Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption
Nehlig, A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014407 · Cited by 632 · cited 1×
“Gene ADORA2A encodes adenosine receptor A2AR, which plays a role in caffeine metabolism [22].”
Background
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613
Adenosine, Adenosine Receptors and the Actions of Caffeine
Fredholm, B. B. (1995) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1995.tb00111.x · Cited by 597
Caffeine and Adenosine
Ribeiro, J. A., & Sebastião, A. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1379 · Cited by 584
Structure and function of adenosine receptors and their genes
Fredholm, B. B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. W. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000313 · Cited by 583
The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557
Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
Cunha, R. A. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-0649-1 · Cited by 555
Coffee, Caffeine, and Health Outcomes: An Umbrella Review
Grosso, G., Godos, J., Galvano, F., & Giovannucci, E. L. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064941 · Cited by 531
Adenosine receptor activation and nociception
Sawynok, J. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01605-1 · Cited by 472
Nutrients and Oxidative Stress: Friend or Foe?
Tan, B. L., Norhaizan, M. E., & Liew, W.-P.-P. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9719584 · Cited by 455
Coffee consumption and risk of type 2 diabetes mellitus
van Dam, R. M., & Feskens, E. J. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11436-x · Cited by 444
Targeting adenosine A2A receptors in Parkinson's disease
Schwarzschild, M. A., Agnati, L. F., Fuxé, K., Chen, J., & Morelli, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.004 · Cited by 441
Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study
Eskelinen, M. H., Ngandu, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-0920 · Cited by 428
Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans
Kaplan, G. B., Greenblatt, D. J., Ehrenberg, B. L., Goddard, J. E., Cotreau, M. M., Harmatz, J. S., & Shader, R. I. (1997) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1997.tb04356.x · Cited by 400
The absolute bioavailability of caffeine in man
Blanchard, J., & Sawers, S. J. A. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00613933 · Cited by 378
Blood pressure response to chronic intake of coffee and caffeine: a meta‐analysis of randomized controlled trials
Noordzij, M., Uiterwaal, C. S., Arends, L. R., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000166828.94699.1d · Cited by 376
Does caffeine intake protect from Alzheimer's disease?
Maia, L., & de Mendonça, A. (2002) · European Journal of Neurology · doi:10.1046/j.1468-1331.2002.00421.x · Cited by 361
Caffeine Can Decrease Insulin Sensitivity in Humans
Keijzers, G. B., De Galan, B. E., Tack, C. J., & Smits, P. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.364 · Cited by 358
Adenosine in the spinal cord and periphery: release and regulation of pain
Sawynok, J., & Liu, X. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00050-9 · Cited by 355
Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
Sinha, R. A., Farah, B. L., Singh, B. K., Siddique, M. M., Li, Y., Wu, Y., Ilkayeva, O., Gooding, J. R., Ching, J., Zhou, J., et al. (2013) · Hepatology · doi:10.1002/hep.26667 · Cited by 348
The neuroprotective effects of caffeine: A prospective population study (the Three City Study)
Ritchie, K., Carrière, I., de Mendonça, A., Portet, F., Dartigues, J. F., Rouaud, O., Barberger-Gateau, P., & Ancelin, M. L. (2007) · Neurology · doi:10.1212/01.wnl.0000266670.35219.0c · Cited by 347
Caffeine use in children: What we know, what we have left to learn, and why we should worry
Temple, J. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.001 · Cited by 335
The neuroprotective effects of caffeine in neurodegenerative diseases
Kolahdouzan, M., & Hamadeh, M. J. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12684 · Cited by 323
Caffeine acts through neuronal adenosine A 2A receptors to prevent mood and memory dysfunction triggered by chronic stress
Kaster, M. P., Machado, N. J., Silva, H. B., Nunes, A., Ardais, A. P., Santana, M., Baqi, Y., Müller, C. E., Rodrigues, A. L. S., Porciúncula, L. O., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423088112 · Cited by 312
Effect of Caffeine Ingestion on Muscular Strength and Endurance
Warren, G. L., PARK, N. D., MARESCA, R. D., MCKIBANS, K. I., & MILLARD-STAFFORD, M. L. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181cabbd8 · Cited by 303
Coffee Consumption and Serum Lipids: A Meta-Analysis of Randomized Controlled Clinical Trials
Jee, S. H., He, J., Appel, L. J., Whelton, P. K., Suh, II, & Klag, M. J. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.4.353 · Cited by 301
Impact of caffeine and coffee on our health
de Mejı́a, E. G., & Ramı́rez-Mares, M. V. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.003 · Cited by 300
Coffee Consumption and Risk of Type 2 Diabetes Mellitus Among Middle-aged Finnish Men and Women
Tuomilehto, J. O. (2004) · JAMA · doi:10.1001/jama.291.10.1213 · Cited by 281
Increased Caffeine Consumption Is Associated With Reduced Hepatic Fibrosis
Modi, A. A., Feld, J. J., Park, Y., Kleiner, D. E., Everhart, J. E., Liang, J. T., & Hoofnagle, J. H. (2009) · Hepatology · doi:10.1002/hep.23279 · Cited by 279
Beverage Use and Risk for Kidney Stones in Women
Curhan, G. C., Willett, W. C., Speizer, F. E., & Stampfer, M. J. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-7-199804010-00003 · Cited by 278
Coffee, Caffeine, and Risk of Depression Among Women
Lucas, M. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.393 · Cited by 270
Pharmacokinetics and metabolism of natural methylxanthines in animal and man
Arnaud, M. J. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_3 · Cited by 259
Caffeine analogs: biomedical impact
Daly, J. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7051-9 · Cited by 259
Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances
Del Coso, J., Muñoz, G., & Muñoz-Guerra, J. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-052 · Cited by 258
Nutrition and the Immune System: A Complicated Tango
Venter, C., Eyerich, S., Sarin, T., & Klatt, K. C. (2020) · Nutrients · doi:10.3390/nu12030818 · Cited by 256
Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis
Bravi, F., Bosetti, C., Tavani, A., Gallus, S., & Vecchia, C. L. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.04.039 · Cited by 252
Molecular biomarkers of Alzheimer's disease: progress and prospects
Lashley, T., Schott, J. M., Weston, P. S. J., Murray, C. E., Wellington, H., Keshavan, A., Foti, S. C., Foiani, M. S., Toombs, J., Rohrer, J. D., et al. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031781 · Cited by 251
Intake of caffeine from all sources and reasons for use by college students
Mahoney, C. R., Giles, G. E., Marriott, B. P., Judelson, D. A., Glickman, E. L., Geiselman, P. J., & Lieberman, H. R. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.004 · Cited by 250
Shaping of monocyte and macrophage function by adenosine receptors
Haskó, G., Pacher, P., Deitch, E. A., & Vizi, E. S. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.003 · Cited by 232
Are the Current Guidelines on Caffeine Use in Sport Optimal for Everyone? Inter-individual Variation in Caffeine Ergogenicity, and a Move Towards Personalised Sports Nutrition
Pickering, C., & Kiely, J. (2017) · Sports Medicine · doi:10.1007/s40279-017-0776-1 · Cited by 228
The pharmacology of caffeine
Arnaud, M. J. (1987) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9289-6_9 · Cited by 226
Influence of Coffee Drinking on Subsequent Risk of Hepatocellular Carcinoma: A Prospective Study in Japan
Inoue, M., Yoshimi, I., Sobue, T., Tsugane, S., & For the JPHC Study Group (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji040 · Cited by 225
Association of Coffee, Decaffeinated Coffee and Caffeine Intake from Coffee with Cognitive Performance in Older Adults: National Health and Nutrition Examination Survey (NHANES) 2011–2014.
Dong, X. Z., Li, S., Sun, J., Li, Y., & Zhang, D. (2020) · Nutrients · doi:10.3390/nu12030840 · Cited by 217
Effects of caffeine on bone and the calcium economy
Heaney, R. P. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00094-7 · Cited by 211
Caffeine as an analgesic adjuvant for acute pain in adults
Derry, C. J., Derry, S., & Moore, R. A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009281.pub3 · Cited by 203
Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
Li, Y., Ouyang, S., Tu, L., Wang, X., Yuan, W., Wang, G.-E., Wu, Y., Duan, W., Yu, H.-M., Fang, Z., et al. (2018) · Theranostics · doi:10.7150/thno.28778 · Cited by 202
Caffeine counteracts the ergogenic action of muscle creatine loading
Vandenberghe, K., Gillis, N., Van Leemputte, M., Van Hecke, P., Vanstapel, F., & Hespel, P. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.2.452 · Cited by 197
Caffeine Intake, Smoking, and Risk of Parkinson Disease in Men and Women
Liu, R., Guo, X., Park, Y., Huang, X., Sinha, R. R., Freedman, N. D., Hollenbeck, A. R., Blair, A. E., & Chen, H. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr451 · Cited by 186
Caffeine and risk of Parkinson’s disease in a large cohort of men and women
Palacios, N., Gao, X., McCullough, M. L., Schwarzschild, M. A., Shah, R., Gapstur, S., & Ascherio, A. (2012) · Movement Disorders · doi:10.1002/mds.25076 · Cited by 185
Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor
Kong, H., Jones, P. P., Koop, A., Zhang, L., Duff, H. J., & Chen, S. R. W. (2008) · Biochemical Journal · doi:10.1042/bj20080489 · Cited by 184
Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study
Zampelas, A., Panagiotakos, D. B., Pitsavos, C. E., Chrysohoou, C. A., & Stefanadis, C. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.862 · Cited by 181
Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children
Richards, G., & Smith, A. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115612404 · Cited by 179
The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine
Womack, C. J., Saunders, M. J., Bechtel, M. K., Bolton, D. J., Martin, M., Luden, N. D., Dunham, W., & Hancock, M. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-7 · Cited by 178
Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies
Martini, D., Bo’, C. D., Tassotti, M., Riso, P., Rio, D. D., Brighenti, F., & Porrini, M. (2016) · Molecules · doi:10.3390/molecules21080979 · Cited by 178
Dietary caffeine intake and the risk for detrusor instability: a case-control study
Arya, L. A. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(00)00808-5 · Cited by 170
Human Consumption of Caffeine
Barone, J., & Roberts, H. R. (1984) · Springer eBooks · doi:10.1007/978-3-642-69823-1_4 · Cited by 167
Acute and long-term cardiovascular effects of coffee: Implications for coronary heart disease
Riksen, N. P., Rongen, G. A. P. J. M., & Smits, P. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.10.006 · Cited by 166
Coffee and Gastrointestinal Function: Facts and Fiction: A Review
J. Boekema, M. S. (1999) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655299750025525 · Cited by 164
A meta‐analysis of coffee, myocardial infarction, and coronary death
Greenland, S. (1993) · Epidemiology · doi:10.1097/00001648-199307000-00013 · Cited by 163
Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer
van Dam, R. M. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-120 · Cited by 161
Coffee and incidence of diabetes in Swedish women: a prospective 18‐year follow‐up study
Rosengren, A., Dotevall, A., Wilhelmsen, L., Thelle, D. S., & Johansson, S. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01260.x · Cited by 157
A Prospective Study of Coffee Drinking and Suicide in Women
Kawachi, I. I. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440050067008 · Cited by 155
Caffeine improves neuromuscular function during maximal dynamic exercise
Bazzucchi, I., Felici, F., Montini, M., Figura, F., & Sacchetti, M. (2011) · Muscle & Nerve · doi:10.1002/mus.21995 · Cited by 152
The Relationship Between Caffeine, Sleep, and Behavior in Children
Watson, E. J., Banks, S., Coates, A. M., & Kohler, M. J. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6536 · Cited by 145
A Brief Outline of the Immune System
Tomar, N., & De, R. K. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1115-8_1 · Cited by 140
Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test
Graham, T. E., Sathasivam, P., Rowland, M., Marko, N., Greer, F., & Battram, D. (2001) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y01-026 · Cited by 135
Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial
Postuma, R. B., Anang, J., Pelletier, A., Joseph, L., Moscovich, M., Grimes, D., Furtado, S., Munhoz, R. P., Appel-Cresswell, S., Moro, A., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004568 · Cited by 135
Is Coffee a Colonie Stimulant?
Rao, S. S. C., Welcher, K., Zimmerman, B., & Stumbo, P. (1998) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199802000-00003 · Cited by 133
Requirement of Intact Adenosine A1 Receptors for the Diuretic and Natriuretic Action of the Methylxanthines Theophylline and Caffeine
Rieg, T., Steigele, H., Schnermann, J., Richter, K., Osswald, H., & Vallon, V. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.080432 · Cited by 133
Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics
Blum, D. L., Hourez, R., Galas, M., Popoli, P., & Schiffmann, S. N. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00411-3 · Cited by 131
Effect of caffeine on bladder function in patients with overactive bladder symptoms
Lohsiriwat, S., Hirunsai, M., & Chaiyaprasithi, B. (2011) · Urology Annals · doi:10.4103/0974-7796.75862 · Cited by 129
Caffeine-Related Deaths: Manner of Deaths and Categories at Risk
Cappelletti, S., Piacentino, D., Fineschi, V., Frati, P., Cipolloni, L., & Aromatario, M. (2018) · Nutrients · doi:10.3390/nu10050611 · Cited by 123
The Role of Caffeine in Pain Management: A Brief Literature Review
Baratloo, A., Rouhipour, A., Forouzanfar, M. M., Safari, S., Amiri, M., & Negida, A. (2015) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.33193 · Cited by 121
Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase
Pohanka, M., & Dobes, P. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059873 · Cited by 120
Role of adenosine receptors in caffeine tolerance.
Holtzman, S. G., Mante, S., & Minneman, K. P. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23061-0 · Cited by 115
Inverse association between caffeine intake and depressive symptoms in US adults: Data from National Health and Nutrition Examination Survey (NHANES) 2005–2006
Iranpour, S., & Sabour, S. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.004 · Cited by 115
Caffeine for asthma
Welsh, E. J., Bara, A., Barley, E. A., & Cates, C. J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001112.pub2 · Cited by 114
Caffeine Consumption and Sleep Quality in Australian Adults
Watson, E., Coates, A., Kohler, M., & Banks, S. (2016) · Nutrients · doi:10.3390/nu8080479 · Cited by 109
Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis
Sang, L.-X., Chang, B., Li, X., & Jiang, M. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-34 · Cited by 107
The Role of Adenosine in Alzheimers Disease
Rahman, A. (2009) · Current Neuropharmacology · doi:10.2174/157015909789152119 · Cited by 106
Molecular Bases Underlying the Hepatoprotective Effects of Coffee
Salomone, F., Galvano, F., & Volti, G. L. (2017) · Nutrients · doi:10.3390/nu9010085 · Cited by 106
Caffeine and 3‐km cycling performance: Effects of mouth rinsing, genotype, and time of day
Pataky, M. W., Womack, C. J., Saunders, M., Goffe, J. L., D’Lugos, A. C., El‐Sohemy, A., & Luden, N. D. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12501 · Cited by 105
Major Components of Energy Drinks (Caffeine, Taurine, and Guarana) Exert Cytotoxic Effects on Human Neuronal SH-SY5Y Cells by Decreasing Reactive Oxygen Species Production
Zeidán‐Chuliá, F., Gelain, D. P., Kolling, E. A., Rybarczyk-Filho, J. L., Ambrosi, P., Terra, S. R., Pires, A. S., da Rocha, J. B. T., Behr, G. A., & Moreira, J. C. F. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/791795 · Cited by 104
The Acute Effects of Caffeinated Black Coffee on Cognition and Mood in Healthy Young and Older Adults
Haskell‐Ramsay, C. F., Jackson, P. A., Forster, J. S., Dodd, F. L., Bowerbank, S. L., & Kennedy, D. O. (2018) · Nutrients · doi:10.3390/nu10101386 · Cited by 104
Long-Term Coffee Consumption is Associated with Fecal Microbial Composition in Humans
González, S., Salazar, N., Ruiz-Saavedra, S., Gómez‐Martín, M., Reyes‐Gavilán, C. G. D. L., & Gueimonde, M. (2020) · Nutrients · doi:10.3390/nu12051287 · Cited by 104
Coffee, caffeine, and risk of completed suicide: Results from three prospective cohorts of American adults
Lucas, M., O’Reilly, E. J., Pan, A., Mirzaei, F., Willett, W. C., Okereke, O. I., & Ascherio, A. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.795243 · Cited by 103
Consumption of coffee or caffeine and serum concentration of inflammatory markers: A systematic review
Paiva, C., Beserra, B. T. S., Reis, C., Dórea, J. G., Costa, T. D., & Amato, A. A. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1386159 · Cited by 102
Caffeine Intake, and the Risk of Stress, Urgency and Mixed Urinary Incontinence
Jura, Y. H., Townsend, M. K., Curhan, G. C., Resnick, N. M., & Grodstein, F. (2011) · The Journal of Urology · doi:10.1016/j.juro.2011.01.003 · Cited by 101
Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease
Fujimaki, M., Saiki, S., Li, Y., Kaga, N., Taka, H., Hatano, T., Ishikawa, K., Oji, Y., Mori, A., Okuzumi, A., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000004888 · Cited by 99
The Effects of High Doses of Caffeine on Maximal Strength and Muscular Endurance in Athletes Habituated to Caffeine
Wilk, M., Krzysztofik, M., Filip-Stachnik, A., Zając, A., & Coso, J. D. (2019) · Nutrients · doi:10.3390/nu11081912 · Cited by 98
Does Coffee Protect Against Liver Cirrhosis?
Gallus, S., Tavani, A., Negri, E., & Vecchia, C. L. (2002) · Annals of Epidemiology · doi:10.1016/s1047-2797(01)00304-0 · Cited by 97
Pathophysiological roles for purines
Morelli, M., Carta, A. R., Kachroo, A., & Schwarzschild, M. A. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)83010-9 · Cited by 96
Caffeine intake, toxicity and dependence and lifetime risk for psychiatric and substance use disorders: An epidemiologic and co-twin control analysis
KENDLER, K. S., MYERS, J., & O. GARDNER, C. (2006) · Psychological Medicine · doi:10.1017/s0033291706008622 · Cited by 96 · cited 1×
“[94] analyzed data from the Virginia Twin Registry of about 3600 adult twins and reported that the risk of developing anxiety increased after consumption of >6 cups of caffeinated coffee per day.”
Method
Coffee consumption and risk of type 2 diabetes in Finnish twins
Carlsson, S. (2004) · International Journal of Epidemiology · doi:10.1093/ije/dyh185 · Cited by 93
Caffeine decreases exhaled nitric oxide
Bruce, C. (2002) · Thorax · doi:10.1136/thorax.57.4.361 · Cited by 92
Coffee Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies
Li, G., Ma, D., Zhang, Y., Zheng, W., & Wang, P. (2013) · Public Health Nutrition · doi:10.1017/s1368980012002601 · Cited by 91
Methylxanthines, Seizures, and Excitotoxicity
Boison, D. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_9 · Cited by 90
Caffeine Modulates TNF-α Production by Cord Blood Monocytes: The Role of Adenosine Receptors
Chavez‐Valdez, R., Wills-Karp, M. A., Ahlawat, R., Cristofalo, E. A., Nathan, A. T., & Gauda, E. B. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31818d66b1 · Cited by 89
Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective than Green Coffees
Chu, Y.-F., Brown, P. H., Lyle, B. J., Chen, Y., Black, R. M., Williams, C. E., Lin, Y.-C., Hsu, C.-W., & Cheng, I. H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902095z · Cited by 89
Association of Tea Consumption with Risk of Alzheimer’s Disease and Anti-Beta-Amyloid Effects of Tea
Polito, C. A., Cai, Z., Shi, Y., Li, X.-M., Yang, R., Shi, M., Li, Q., Ma, S., Xiang, L., Wang, K., et al. (2018) · Nutrients · doi:10.3390/nu10050655 · Cited by 89
Caffeine and urinary incontinence in US women
Gleason, J. L., Richter, H. E., Redden, D. T., Goode, P. S., Burgio, K. L., & Markland, A. D. (2012) · International Urogynecology Journal · doi:10.1007/s00192-012-1829-5 · Cited by 88
Adenosine Enhances Sweet Taste through A2B Receptors in the Taste Bud
Dando, R., Dvoryanchikov, G. A., Pereira, E., Chaudhari, N., & Roper, S. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4070-11.2012 · Cited by 87
CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study
Salinero, J. J., Lara, B., Ruiz-Vicente, D., Areces, F., Puente, C., Gallo–Salazar, C., Pascual, T., & Coso, J. D. (2017) · Nutrients · doi:10.3390/nu9030269 · Cited by 87
Coffee, tea, mate, methylxanthines and methylglyoxal. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 27 February to 6 March 1990.
(1991) · PubMed Central · Cited by 86
Reflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role of adenosine.
Thames, M. D., Kinugawa, T., & Dibner‐Dunlap, M. E. (1993) · Circulation · doi:10.1161/01.cir.87.5.1698 · Cited by 82
Neuroprotective Effects of Synaptic Modulation in Huntington's Disease R6/2 Mice
Stack, E. C., Dedeoglu, A., Smith, K. M., Cormier, K., Kubilus, J. K., Bogdanov, M. B., Matson, W. R., Yang, L., Jenkins, B. G., Luthi‐Carter, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4318-07.2007 · Cited by 80
Opposite actions of caffeine and creatine on muscle relaxation time in humans
Hespel, P., ‘t Eijnde, B. O., & Van Leemputte, M. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00255.2001 · Cited by 78
Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway
Liu, H., Zhou, Y., & Tang, L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6894 · Cited by 78
High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies
Hedström, A. K., Mowry, E. M., Gianfrancesco, M. A., Shao, X., Schaefer, C. A., Shen, L., Olsson, T., Barcellos, L. F., & Alfredsson, L. (2016) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-312176 · Cited by 77
Coffee consumption and risk of cardiovascular events and all-cause mortality among women with type 2 diabetes
Zhang, W. L., López‐García, E., Li, T. Y., Hu, F. B., & van Dam, R. M. (2009) · Diabetologia · doi:10.1007/s00125-009-1311-1 · Cited by 76
Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria
Xu, H., Gan, C., Gao, Z., Huang, Y., Wu, S., Zhang, D., Wang, X., & Sheng, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00822 · Cited by 74
Association between caffeine intake and age at onset in Huntington's disease
Simonin, C., Duru, C., Salleron, J., Hincker, P., Charles, P., Delval, A., Youssov, K., Burnouf, S., Azulay, J., Verny, C., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.05.013 · Cited by 73
Caffeine prevents kidney stone formation by translocation of apical surface annexin A1 crystal-binding protein into cytoplasm: In vitro evidence
Peerapen, P., & Thongboonkerd, V. (2016) · Scientific Reports · doi:10.1038/srep38536 · Cited by 73
Coffee consumption and decreased serum γ-glutamyltransferase: a study of middle-aged Japanese men
Nakanishi, N., Nakamura, K., Nakajima, K., Suzuki, K., & Tatara, K. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007683626665 · Cited by 72
Effect of Caffeine Intake on Pain Perception During High-Intensity Exercise
Astorino, T. A., Terzi, M. N., Roberson, D. W., & Burnett, T. R. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.1.27 · Cited by 71
A Randomised Placebo-Controlled Trial to Differentiate the Acute Cognitive and Mood Effects of Chlorogenic Acid from Decaffeinated Coffee
Camfield, D., Silber, B. Y., Scholey, A. B., Nolidin, K., Goh, A. W.-T., & Stough, C. K. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082897 · Cited by 71
Effect of caffeine on control of breathing in infantile apnea
Aranda, J. V., Türmen, T., Davis, J. M., Trippenbach, T., Grondin, D., Zinman, R., & Watters, G. V. (1983) · The Journal of Pediatrics · doi:10.1016/s0022-3476(83)80735-5 · Cited by 70
The effects of caffeine and theophylline on diaphragm contractility.
Supinski, G. S., Deal, E. C., & Kelsen, S. G. (1984) · PubMed · doi:10.1164/arrd.1984.130.3.429 · Cited by 68
Effect of caffeine on respiratory muscle strength and lung function in prematurely born, ventilated infants
Kassim, Z., Greenough, A., & Rafferty, G. F. (2009) · European Journal of Pediatrics · doi:10.1007/s00431-009-0961-9 · Cited by 67
Is Caffeine Addictive?—A Review of the Literature
Satel, S. L. (2006) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990600918965 · Cited by 66
Adenosine for pain control
Sollevi, A. (1997) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1997.tb05532.x · Cited by 66
Heavy coffee drinking and the risk of suicide
Tanskanen, A. J., Tuomilehto, J., Viinamäki, H. T., Vartiainen, E. A., Lehtonen, J., & Puska, P. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007614714579 · Cited by 63
Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind trial.
Dusseldorp, M., Smits, P., Thien, T. A., & Katan, M. (1989) · Hypertension · doi:10.1161/01.hyp.14.5.563 · Cited by 63
Effect of caffeine on biomarkers of oxidative stress in lenses of rats with streptozotocin-induced diabetes
Kaczmarczyk‐Sedlak, I., Folwarczna, J., Sedlak, L., Zych, M., Wojnar, W., Szumińska, I., Wyględowska‐Promieńska, D., & Mrukwa–Kominek, E. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.85461 · Cited by 63
Caffeine Is Ergogenic for Adenosine A 2A Receptor Gene ( ADORA2A ) T Allele Homozygotes: A Pilot Study
Loy, B. D., O’Connor, P. J., Lindheimer, J. B., & Covert, S. F. (2015) · Journal of Caffeine Research · doi:10.1089/jcr.2014.0035 · Cited by 62
The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults
Carswell, A. T., Howland, K., Martinez-Gonzalez, B., Baron, P., & Davison, G. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04384-8 · Cited by 61
A Combination of Caffeine, Arginine, Soy Isoflavones, and l-Carnitine Enhances Both Lipolysis and Fatty Acid Oxidation in 3T3-L1 and HepG2 Cells in Vitro and in KK Mice in Vivo
Murosaki, S., Lee, T. R., Muroyama, K., Shin, E. S., Cho, S. Y., Yamamoto, Y., & Lee, S. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.10.2252 · Cited by 60
Changes in pulmonary mechanics following caffeine administration in infants with bronchopulmonary dysplasia
Davis, J. M., Bhutani, V. K., Stefano, J. L., Fox, W. W., & Spitzer, A. R. (1989) · Pediatric Pulmonology · doi:10.1002/ppul.1950060112 · Cited by 60
Caffeine Intake and Mental Health in College Students
Bertasi, R. A. O., Humeda, Y., Bertasi, T. G. O., Zins, Z., Kimsey, J., & Pujalte, G. G. A. (2021) · Cureus · doi:10.7759/cureus.14313 · Cited by 58
Acute caffeine intake increases muscle oxygen saturation during a maximal incremental exercise test
Ruíz‐Moreno, C., Lara, B., de Souza, D. B., Gutiérrez‐Hellín, J., Romero‐Moraleda, B., Cuéllar-Rayo, Á., & Coso, J. D. (2019) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14189 · Cited by 53
Caffeine in the Treatment of Pain
Tavares, C., & Sakata, R. K. (2012) · Brazilian Journal of Anesthesiology · doi:10.1016/s0034-7094(12)70139-3 · Cited by 52
Coffee Consumption and Risk of Colorectal Cancer: A Dose-Response Analysis of Observational Studies
Tian, C., Wang, W., Hong, Z., & Zhang, X. (2013) · Cancer Causes & Control · doi:10.1007/s10552-013-0200-6 · Cited by 51
Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons
Rebola, N., Rodrigues, R. J., Oliveira, C. R., & Cunha, R. A. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.05.009 · Cited by 50
Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention
Helal, M. G., Ayoub, S., Elkashefand, W., & Ibrahim, T. (2017) · Human & Experimental Toxicology · doi:10.1177/0960327117747026 · Cited by 49
Caffeine relaxes smooth muscle through actin depolymerization
Tazzeo, T., Bates, G., Roman, H. N., Lauzon, A., Khasnis, M. D., Eto, M., & Janssen, L. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00103.2012 · Cited by 48
Caffeine toxicity in forensic practice: possible effects and under-appreciated sources
Musgrave, I., Farrington, R., Hoban, C. L., & Byard, R. W. (2016) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-016-9786-9 · Cited by 48
The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease
Blum, D. L., Chern, Y., Domenici, M. R., Buée, L., Lin, C., Rea, W. P., Ferré, S., & Popoli, P. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2018.0006 · Cited by 48
Coffee increases state anxiety in males but not in females
Botella, P., & Parra, A. (2003) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.444 · Cited by 47
Associations Between Black Tea and Coffee Consumption and Risk of Lung Cancer Among Current and Former Smokers
Baker, J. A., McCann, S. E., Reid, M. E., Nowell, S. A., Beehler, G. P., & Moysich, K. B. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5201_2 · Cited by 45
The influence of different food components on thein vitroavailability of iron, zinc and calcium from a composed meal
Dyck, K. V., Tas, S., Robberecht, H. J., & Deelstra, H. A. (1996) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637489609031879 · Cited by 44
The Effects of a Polymorphism in the Cytochrome P450 CYP1A2 Gene on Performance Enhancement with Caffeine in Recreational Cyclists
AlGrain, H. A., Thomas, R. M., Carrillo, A. E., Ryan, E. J., Kim, C.-H., Lettan, R. B. I., & Ryan, E. J. (2015) · Journal of Caffeine Research · doi:10.1089/jcr.2015.0029 · Cited by 44
Mécanismes de l’effet diurétique de la caféine
Marx, B., Scuvée, É., Scuvée‐Moreau, J., Seutin, V., & Jouret, F. (2016) · médecine/sciences · doi:10.1051/medsci/20163205015 · Cited by 44
Autophagy mediated by endoplasmic reticulum stress enhances the caffeine-induced apoptosis of hepatic stellate cells
Li, Y., Chen, Y., Huang, H., Shi, M., Yang, W., Kuang, J., & Yan, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3145 · Cited by 44
Are caffeine’s performance-enhancing effects partially driven by its bitter taste?
Pickering, C. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109301 · Cited by 44
Caffeine Consumption and Mortality in Diabetes: An Analysis of NHANES 1999–2010
Neves, J. S., Leitão, L., Magriço, R., Vieira, M. B., Dias, C. V., Oliveira, A. B. F. D., Carvalho, D. M., & Claggett, B. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00547 · Cited by 43
Caffeine Intake and Risk of Urinary Incontinence Progression Among Women
Townsend, M. K., Resnick, N. M., & Grodstein, F. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31824fc604 · Cited by 42
Caffeine inhibits hypoxia-induced renal fibroblast activation by antioxidant mechanism
Nilnumkhum, A., Kanlaya, R., Yoodee, S., & Thongboonkerd, V. (2019) · Cell Adhesion & Migration · doi:10.1080/19336918.2019.1638691 · Cited by 39
Caffeine-Induced Effects on Human Skeletal Muscle Contraction Time and Maximal Displacement Measured by Tensiomyography
Domaszewski, P., Pakosz, P., Konieczny, M., Bączkowicz, D., & Sadowska‐Krępa, E. (2021) · Nutrients · doi:10.3390/nu13030815 · Cited by 39
Caffeinated and decaffeinated coffee consumption and risk of all‐cause mortality: a dose–response meta‐analysis of cohort studies
Li, Q., Liu, Y., Sun, X., Yin, Z., Li, H., Cheng, C., Liu, L., Zhang, R., Liu, F., Zhou, Q., et al. (2019) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12633 · Cited by 38
Coffee and tea consumption and risk of lung cancer: A dose–response analysis of observational studies
Wang, Y., Yu, X., Wu, Y., & Zhang, D. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.08.009 · Cited by 37
Caffeine Augments The Instruction of Anti-Inflammatory Macrophages by The Conditioned Medium of Mesenchymal Stem Cells.
Shushtari, N., & Froushani, S. M. A. (2017) · PubMed Central · doi:10.22074/cellj.2017.4364 · Cited by 36
The Effect of Caffeine on Performance in Collegiate Tennis Players
Klein, C. S., Clawson, A. J., Martin, M., Saunders, M. J., Flohr, J. A., Bechtel, M. K., Dunham, W., Hancock, M., & Womack, C. J. (2012) · Journal of Caffeine Research · doi:10.1089/jcr.2012.0019 · Cited by 35
Caffeine: Implications for Alertness in Athletes
Rogers, N. L., & Dinges, D. F. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.012 · Cited by 35
Caffeine, Through Adenosine A3 Receptor-Mediated Actions, Suppresses Amyloid-β Protein Precursor Internalization and Amyloid-β Generation
Li, S., Geiger, N. H., Soliman, M. L., Hui, L., Geiger, J. D., & Chen, X. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142223 · Cited by 35
Untitled work
(2015) · PubMed · Cited by 35
Association Between Caffeine Intake and All-Cause and Cause-Specific Mortality: A Population-Based Prospective Cohort Study
Tsujimoto, T., Kajio, H., & Sugiyama, T. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.03.010 · Cited by 34
Potential Role of Caffeine in the Treatment of Parkinson’s Disease
Roshan, M. H. K., Tambo, A., & Pace, N. P. (2016) · The Open Neurology Journal · doi:10.2174/1874205x01610010042 · Cited by 33
Caffeine and Progression of Parkinson Disease
Simon, D. K., Wu, C., Tilley, B. C., Wills, A.-M. A., Aminoff, M. J., Bainbridge, J. L., Hauser, R. A., Schneider, J. S., Sharma, S., Singer, C., et al. (2015) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000102 · Cited by 31
Effect of caffeine on lower esophageal sphincter pressure in Thai healthy volunteers
Lohsiriwat, S., Puengna, N., & Leelakusolvong, S. (2006) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2006.00562.x · Cited by 30
A dose–response meta-analysis of coffee consumption and bladder cancer
Zhou, Y., Tian, C., & Jia, C. (2012) · Preventive Medicine · doi:10.1016/j.ypmed.2012.04.020 · Cited by 30
Selected health and lifestyle factors, cytosine‐adenine‐guanine status, and phenoconversion in Huntington's disease
Tanner, C. M., Marder, K. S., Eberly, S. W., Biglan, K., Oakes, D., Shoulson, I., & on behalf of the Huntington Study Group Prospective Huntington At‐Risk Observational Study Investigators (2018) · Movement Disorders · doi:10.1002/mds.27239 · Cited by 29
Caffeine consumption and mortality in chronic kidney disease: a nationally representative analysis
Vieira, M. B., Magriço, R., Dias, C. V., Leitão, L., & Neves, J. S. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfy234 · Cited by 29
In-vitro examination of the positive inotropic effect of caffeine and taurine, the two most frequent active ingredients of energy drinks
Chaban, R., Kornberger, A., Branski, N., Buschmann, K., Stumpf, N., Beiras-Fernández, A., & Vahl, C. (2017) · BMC Cardiovascular Disorders · doi:10.1186/s12872-017-0625-z · Cited by 28
The effects of a caffeine-like supplement, TeaCrine®, on muscular strength, endurance and power performance in resistance-trained men
Cesareo, K. R., Mason, J., Saracino, P. G., Morrissey, M. C., & Ormsbee, M. J. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0316-5 · Cited by 28
Mechanisms of modulation of cytokine release by human cord blood monocytes exposed to high concentrations of caffeine
Chavez‐Valdez, R., Ahlawat, R., Wills-Karp, M. A., & Gauda, E. B. (2016) · Pediatric Research · doi:10.1038/pr.2016.50 · Cited by 27
Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample
Overstreet, D. S., Penn, T. M., Cable, S. T., Aroke, E. N., & Goodin, B. R. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5016-3 · Cited by 26
Effect of single caffeine intake on neuropsychological functions in healthy volunteers: A double-blind placebo-controlled study
Konishi, Y., Hori, H., Ide, K., Katsuki, A., Atake, K., Igata, R., Kubo, T., Tominaga, H., Beppu, H., Asahara, T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202247 · Cited by 26
Acute doses of caffeine shift nervous system cell expression profiles toward promotion of neuronal projection growth
Yu, N. Y., Bieder, A., Raman, A., Mileti, E., Katayama, S., Einarsdottir, E., Fredholm, B., Falk, A., Tapia-Páez, I., Daub, C. O., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11574-6 · Cited by 22
Caffeine impairs gastrointestinal function in newborn rats
Welsh, C., Pan, J., & Belik, J. (2015) · Pediatric Research · doi:10.1038/pr.2015.65 · Cited by 21
Caffeine affects the biological responses of human hematopoietic cells of myeloid lineageviadownregulation of the mTOR pathway and xanthine oxidase activity
Gibbs, B. F., Silva, I. G., Prokhorov, A., Abooali, M., Yasinska, I. M., Casely‐Hayford, M. A., Berger, S., Fasler‐Kan, E., & Sumbayev, V. V. (2015) · Oncotarget · doi:10.18632/oncotarget.5212 · Cited by 20
Taste Perception and Caffeine Consumption: An fMRI Study
Gramling, L., Kapoulea, E. A., & Murphy, C. (2018) · Nutrients · doi:10.3390/nu11010034 · Cited by 20
Caffeine and NAD+ Improve Motor Neural Integrity of Dissociated Wobbler Cells In Vitro
Zwilling, M., Theiß, C., & Matschke, V. (2020) · Antioxidants · doi:10.3390/antiox9060460 · Cited by 20
Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study
Wu, S. E., & Chen, W. (2020) · Nutrients · doi:10.3390/nu12092803 · Cited by 20
High doses of caffeine reduce in vivo osteogenic activity in prepubertal rats
Shin, J., Choi, Y., Kim, J., Yu, A., Shin, J., Choi, Y. Y., & Roh, J. (2015) · Journal of Anatomy · doi:10.1111/joa.12332 · Cited by 18
Caffeine May Reduce Perceived Sweet Taste in Humans, Supporting Evidence That Adenosine Receptors Modulate Taste
Choo, E., Picket, B., & Dando, R. (2017) · Journal of Food Science · doi:10.1111/1750-3841.13836 · Cited by 17
Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine
Steck, R., Hill, S. L., Weagel, E. G., Weber, K. S., Robison, R. A., & O'Neill, K. L. (2015) · Pharmacology Research & Perspectives · doi:10.1002/prp2.180 · Cited by 16
Caffeine Targets G6PDH to Disrupt Redox Homeostasis and Inhibit Renal Cell Carcinoma Proliferation
Xu, H., Hu, L., Liu, T., Chen, F., Li, J., Xu, J., Jiang, L., Xiang, Z., Wang, X., & Sheng, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.556162 · Cited by 16
Is Caffeine Intake Associated With Urinary Incontinence in Japanese Adults?
Hirayama, F., & Lee, A. H. (2012) · Journal of Preventive Medicine and Public Health · doi:10.3961/jpmph.2012.45.3.204 · Cited by 14
Caffeine increases myoglobin expression via the cyclic AMP pathway in L6 myotubes
Yokokawa, T., Hashimoto, T., & Iwanaka, N. (2021) · Physiological Reports · doi:10.14814/phy2.14869 · Cited by 13
Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons via Inhibition of Intracellular Phosphodiesterase
Yang, J. Y., Yang, G., Ren, J. T., Zhao, J., & Li, S. (2015) · Neurophysiology · doi:10.1007/s11062-015-9506-1 · Cited by 12
The mechanism of caffeine-enhanced glucose stimulation of liver glycogen synthase phosphatase activity
Gilboe, D. P. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90576-9 · Cited by 12
Effects of upper respiratory tract illnesses, ibuprofen and caffeine on reaction time and alertness
Smith, A. P., & Nutt, D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3339-7 · Cited by 12
Impact of caffeine on myocardial perfusion reserve assessed by semiquantitative adenosine stress perfusion cardiovascular magnetic resonance
Seitz, A., Kaesemann, P., Chatzitofi, M., Löbig, S., Tauscher, G., Bekeredjian, R., Sechtem, U. P., Mahrholdt, H., & Greulich, S. (2019) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-019-0542-7 · Cited by 12
Caffeine Intake and the Risk of Chronic Obstructive Pulmonary Disease in Japanese Adults
Hirayama, F., Lee, A. H., Yasukawa, K., Ishihara, Y., & Shinjo, M. (2012) · Journal of Caffeine Research · doi:10.1089/jcr.2012.0029 · Cited by 10
Caffeine Increases Apolipoprotein A-1 and Paraoxonase-1 but not Paraoxonase-3 Protein Levels in Human-Derived Liver (HepG2) Cells
Özgün, G. S., Özgün, E., Tabakçioğlu, K., Gökmen, S. S., Eskiocak, S., & Çakır, E. (2017) · Balkan Medical Journal · doi:10.4274/balkanmedj.2016.1217 · Cited by 8

Flagged first, then by citations

1 of the 205 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Chawla, 2015, Neurologic Effects of Caffeine Physiologic Effects of Caffeine, Medscape Ref. Drug Dis. Proced., 24, 1
Nikolajsen, 2013, Koffein som adjuverende analgetikum til behandling af akutte smerter-en gennemgang af et Cochranereview, Ugeskr Læger, 175, 2486
Bojarowicz, 2012, Powszechność stosowania kofeiny oraz jej działanie na organizm Caffeine. Part, I. Common use of caffeine and its effect on human organism, Probl. Hig. Epidemiol., 93, 8

Sorted by citations

The effect of caffeine on subsequent sleep: A systematic review and meta-analysis
Gardiner, C., Weakley, J., Burke, L. M., Roach, G. D., Sargent, C., Maniar, N., Townshend, A., & Halson, S. L. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101764 · Cited by 357
A review on the influence of nutraceuticals and functional foods on health
Vignesh, A., Amal, T. C., Sarvalingam, A., & Vasanth, K. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100749 · Cited by 249
Caffeine and Its Antioxidant Properties—It Is All about Dose and Source
Ősz, B.-E., Jîtcă, G., Ștefănescu, R., Puşcaş, A., Tero-Vescan, A., & Vari, C.-E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113074 · Cited by 155
The medicinal and aromatic plants as ingredients in functional beverage production
Maleš, I., Pedišić, S., Zorić, Z., Garofulić, I. E., Repajić, M., You, L., Vladimir‐Knežević, S., Butorac, D., & Dragović‐Uzelac, V. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105210 · Cited by 127
Bioactive compounds in coffee and their role in lowering the risk of major public health consequences: A review
Urugo, M. M., Tola, Y. B., Ogah, O., & Endale, F. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3848 · Cited by 142

See all 188

Authors: Rodak, K., Kokot, I., & Kratz, E. M.
Affiliations: Wroclaw Medical University (PL)
Corresponding author: Rodak, Kamil
Kratz, Ewa Maria
ORCID: Rodak, Kamil
Kokot, Izabela
Kratz, Ewa Maria
Venue: Nutrients
Publisher: MDPI AG
Published: 2021-09-02
Volume: 13
Issue: 9
Pages: 3088
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu13093088
PMC: PMC8467199
OpenAlex: W3198497028
Cited by: 188
References: 205
Citations by year: 2026: 27 · 2025: 64 · 2024: 49 · 2023: 33 · 2022: 15
FWCI: 3.07
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
Keywords: caffeine, purine alkaloids, caffeine consumption, health effects of caffeine, central nervous system, immune system, digestive system, respiratory system, urinary tract, asthma, Parkinson's disease, hypertension, children and adolescents, older adults, antioxidant activity
MeSH terms: Adolescent, Adult, Central Nervous System Stimulants, Analgesics, Animals, Antioxidants, Mental Disorders, Caffeine, Cardiovascular System, Child, Digestive System, Humans, Immune System, Respiratory System, Urinary Tract, Receptors, Purinergic P1, Neurodegenerative Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Caffeine as a factor influencing the functioning of the human body-friend or foe?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks