The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Alcohol and Cancer: Epidemiology and Biological Mechanisms
Open accessAbstract
Approximately 4% of cancers worldwide are caused by alcohol consumption. Drinking alcohol increases the risk of several cancer types, including cancers of the upper aerodigestive tract, liver, colorectum, and breast. In this review, we summarise the epidemiological evidence on alcohol and cancer risk and the mechanistic evidence of alcohol-mediated carcinogenesis. There are several mechanistic pathways by which the consumption of alcohol, as ethanol, is known to cause cancer, though some are still not fully understood. Ethanol’s metabolite acetaldehyde can cause DNA damage and block DNA synthesis and repair, whilst both ethanol and acetaldehyde can disrupt DNA methylation. Ethanol can also induce inflammation and oxidative stress leading to lipid peroxidation and further DNA damage. One-carbon metabolism and folate levels are also impaired by ethanol. Other known mechanisms are discussed. Further understanding of the carcinogenic properties of alcohol and its metabolites will inform future research, but there is already a need for comprehensive alcohol control and cancer prevention strategies to reduce the burden of cancer attributable to alcohol.
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Cites
Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Shin, N.-R., Whon, T. W., & Bae, J.-W. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.06.011 · Cited by 3,954
IARC monographs on the evaluation of carcinogenic risks to humans
Hopkins, J. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90054-9 · Cited by 2,876
Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis
Bagnardi, V, Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V, Scotti, L., Jenab, M., Turati, F., Pasquali, E., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2014.579 · Cited by 1,342 · cited 7×
“Source of relative risk estimates: Bagnardi and colleagues [8].”
BackgroundInfluentialHashibe, M., Brennan, P., Chuang, S.-C., Boccia, S., Castellsague, X., Chen, C., Curado, M. P., Dal Maso, L., Daudt, A. W., Fabianova, E., et al. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0347 · Cited by 1,256
Alcohol, oxidative stress and free radical damage
Albano, E. (2006) · Proceedings of the Nutrition Society · doi:10.1079/pns2006496 · Cited by 1,215
Molecular mechanisms of alcohol-mediated carcinogenesis
Seitz, H. K., & Stickel, F. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2191 · Cited by 1,138
Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study
Manthey, J., Shield, K. D., Rylett, M., Hasan, O. S. M., Probst, C., & Rehm, J. (2019) · The Lancet · doi:10.1016/s0140-6736(18)32744-2 · Cited by 856
Personal habits and indoor combustions.
(2012) · PubMed · Cited by 748
Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study
Rumgay, H., Shield, K., Charvat, H., Ferrari, P., Sornpaisarn, B., Obot, I., Islami, F., Lemmens, V. E. P. P., Rehm, J., & Soerjomataram, I. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00279-5 · Cited by 683
Self-citationGlobal burden of oesophageal and gastric cancer by histology and subsite in 2018
Arnold, M., Ferlay, J., van Berge Henegouwen, M. I., & Soerjomataram, I. (2020) · Gut · doi:10.1136/gutjnl-2020-321600 · Cited by 599
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Metadata
- Authors
- Rumgay, H., Murphy, N., Ferrari, P., & Soerjomataram, I.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-09-11
- Volume
- 13
- Issue
- 9
- Pages
- 3173
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W3201316265
- Cited by
- 394
- References
- 46
- FWCI
- 29.38
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
