Proteobacteria: Microbial signature of dysbiosis in gut microbiota
Abstract
Recent advances in sequencing techniques, applied to the study of microbial communities, have provided compelling evidence that the mammalian intestinal tract harbors a complex microbial community whose composition is a critical determinant of host health in the context of metabolism and inflammation. Given that an imbalanced gut microbiota often arises from a sustained increase in abundance of the phylum Proteobacteria, the natural human gut flora normally contains only a minor proportion of this phylum. Here, we review studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community. We also propose that an increased prevalence of Proteobacteria is a potential diagnostic signature of dysbiosis and risk of disease.
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The Proteobacteria phylum is a marker of dysbiosis in the gut microbiome.
“The Proteobacteria phylum is a marker of dysbiosis in the gut microbiome, and Proteobacteria with pro-inflammatory characteristics are often overexpressed in gastrointestinal and immune diseases [48].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [48]
Proteobacteria with pro-inflammatory characteristics are often overexpressed in gastrointestinal and immune diseases.
“The Proteobacteria phylum is a marker of dysbiosis in the gut microbiome, and Proteobacteria with pro-inflammatory characteristics are often overexpressed in gastrointestinal and immune diseases [48].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [48]
Proteobacteria is associated with host inflammation.
“Meanwhile, as microbial signature of dysbiosis in gut microbiota, Proteobacteria is associated with host inflammation36.”
From Altered composition and function of intestinal microbiota in autism spectrum disorders: A systematic review (2019) · cites this paper as [36]
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- Authors
- Shin, N.-R., Whon, T. W., & Bae, J.-W.
- Affiliations
- Kyung Hee University (KR)
- Corresponding author
- Bae, Jin-Woo
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 33
- Issue
- 9
- Pages
- 496-503
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W1647551795
- Cited by
- 3,954
- References
- 84
- Citations by year
- 2026: 484 · 2025: 552 · 2024: 573 · 2023: 531 · 2022: 544 · 2021: 461 · 2020: 340 · 2019: 211 · 2018: 133 · 2017: 70 · 2016: 52 · 2015: 1
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Proteobacteria, gut microbiota, dysbiosis, host health, inflammation, diagnostic signature
- MeSH terms
- Gastrointestinal Microbiome, Animals, Environmental Microbiology, Humans, Proteobacteria, Dysbiosis
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