Cited by 3,954Gut microbiota and healthOral microbiology and periodontitis researchGastrointestinal motility and disorders

Proteobacteria: Microbial signature of dysbiosis in gut microbiota

Shin, Na-Ri, Whon, Tae Woong, Bae, Jin-Woo·2015·Trends in Biotechnology

Abstract

Recent advances in sequencing techniques, applied to the study of microbial communities, have provided compelling evidence that the mammalian intestinal tract harbors a complex microbial community whose composition is a critical determinant of host health in the context of metabolism and inflammation. Given that an imbalanced gut microbiota often arises from a sustained increase in abundance of the phylum Proteobacteria, the natural human gut flora normally contains only a minor proportion of this phylum. Here, we review studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community. We also propose that an increased prevalence of Proteobacteria is a potential diagnostic signature of dysbiosis and risk of disease.

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Crossref · 10.1016/j.tibtech.2015.06.011

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Authors
Shin, N.-R., Whon, T. W., & Bae, J.-W.
Affiliations
Kyung Hee University (KR)
Corresponding author
Bae, Jin-Woo
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2015-09
Volume
33
Issue
9
Pages
496-503
ISSN
0167-7799 (ISSN-L)
OpenAlex
W1647551795
Cited by
3,954
References
84
Citations by year
2026: 484 · 2025: 552 · 2024: 573 · 2023: 531 · 2022: 544 · 2021: 461 · 2020: 340 · 2019: 211 · 2018: 133 · 2017: 70 · 2016: 52 · 2015: 1
FWCI
8.32
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Proteobacteria, gut microbiota, dysbiosis, host health, inflammation, diagnostic signature
MeSH terms
Gastrointestinal Microbiome, Animals, Environmental Microbiology, Humans, Proteobacteria, Dysbiosis

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