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Cited by 25Gestational Diabetes Research and ManagementFood composition and propertiesNatural Antidiabetic Agents Studies

Effects of additional dietary fiber supplements on pregnant women with gestational diabetes: a systematic review and meta-analysis of randomized controlled studies

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Sun, Jihan, Wang, Jinjing, Ma, Wenqing, Miao, Miao, Sun, Guiju·2022·Nutrients
DOI 10.3390/nu14214626PMC PMC9658588
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Abstract

The efficacy of different types and doses of dietary fiber supplementation in the treatment of gestational diabetes (GDM) remains controversial. The purpose of this study is to investigate the effect of dietary fiber on blood glucose control in pregnant women with gestational diabetes mellitus, and further observe the effect on their blood lipids and pregnancy outcomes. We searched on Web of Science, PubMed, Embase, Scopus, and Cochrane, and included several articles on additional fortification with dietary fiber for gestational diabetes interventions. This meta-analysis included 8 trials. We found that additional dietary fiber supplements significantly reduced fasting glucose (Hedges’g = −0.3; 95% CI [−0.49, −0.1]), two-hour postprandial glucose (Hedges’g = −0.69; 95% CI [−0.88, −0.51]), glycated hemoglobin (Hedges’g = −0.5; 95% CI [−0.68, −0.31]), TC (Hedges’g = −0.44; 95% CI [−0.69, −0.19]), TG (Hedges’g = −0.3; 95% CI [−0.4, −0.2]) and LDL-C (Hedges’g = −0.48; 95% CI [−0.63, −0.33]). It also significantly reduced preterm delivery (Hedges’g = 0.4, 95% CI [0.19~0.84]), cesarean delivery (Hedges’g = 0.6; 95% CI [0.37~0.97]), fetal distress (Hedges’g = 0.51; 95% CI [0.22~1.19]), and neonatal weight (Hedges’g = −0.17; 95% CI [−0.27~−0.07]). In a subgroup analysis comparing dietary fiber type and dose, insoluble dietary fiber was more effective than soluble dietary fiber in reducing fasting glucose (Hedges’g = −0.44; 95% CI [−0.52, −0.35]). ≥12 g fiber per day may be more effective in improving glycemic lipid and pregnancy outcomes than <12 g/day, but the difference was not statistically significant. In conclusion, our meta-analysis showed that dietary fiber supplementation significantly improved glycolipid metabolism and pregnancy outcomes in gestational diabetes. Dietary fiber may be considered adjunctive therapy for gestational diabetes, and an additional supplement with insoluble dietary fiber is more recommended for those with poor fasting glucose. However, more high-quality studies are needed on the further effect of fiber type and the dose-effect relationship.

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Cited by

Sorted by citations

Authors
Sun, J., Wang, J., Ma, W., Miao, M., & Sun, G.
Affiliations
  • Southeast University (CN)
  • Nanjing Maternity and Child Health Care Hospital (CN)
Corresponding author
Sun, Guiju
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2022-11-02
Volume
14
Issue
21
Pages
4626
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu14214626
PMC
PMC9658588
OpenAlex
W4309089964
Cited by
25
References
4
Citations by year
2026: 4 · 2025: 10 · 2024: 7 · 2023: 4
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Jiangsu Graduate Research and Practice Innovation Program (SJCX21 0024)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
gestational diabetes mellitus, dietary fiber supplementation, glycemic control, HbA1c, serum lipids, pregnancy outcomes, preterm birth, cesarean section, fetal distress, birth weight, insoluble dietary fiber, soluble dietary fiber, fasting blood glucose, postprandial blood glucose, LDL cholesterol, triglycerides, total cholesterol, prenatal nutrition
MeSH terms
Blood Glucose, Dietary Fiber, Female, Humans, Infant, Newborn, Pregnancy, Diabetes, Gestational, Dietary Supplements, Pregnant People, Pregnant Women

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