Dietary fiber intake and risk of type 2 diabetes: a dose–response analysis of prospective studies
Abstract
Observational studies suggest an association between dietary fiber intake and risk of type 2 diabetes, but the results are inconclusive. We conducted a meta-analysis of prospective studies evaluating the associations of dietary fiber intake and risk of type 2 diabetes. Relevant studies were identified by searching EMBASE (from 1974 to April 2013) and PubMed (from 1966 to April 2013). The fixed or random-effect model was selected based on the homogeneity test among studies. In addition, a 2-stage random-effects dose-response meta-analysis was performed. We identified 17 prospective cohort studies of dietary fiber intake and risk of type 2 diabetes involving 19,033 cases and 488,293 participants. The combined RR (95 % CI) of type 2 diabetes for intake of total dietary fiber, cereal fiber, fruit fiber and insoluble fiber was 0.81 (0.73-0.90), 0.77 (0.69-0.85), 0.94 (0.88-0.99) and 0.75 (0.63-0.89), respectively. A nonlinear relationship was found of total dietary fiber intake with risk of type 2 diabetes (P for nonlinearity < 0.01), and the RRs (95 % CI) of type 2 diabetes were 0.98 (0.90-1.06), 0.97 (0.87-1.07), 0.89 (0.80-0.99), 0.76 (0.65-0.88), and 0.66 (0.53-0.82) for 15, 20, 25, 30, and 35 g/day. The departure from nonlinear relationship was not significant (P for nonlinearity = 0.72), and the risk of type 2 diabetes decreased by 6 % (RR 0.94, 95 % CI 0.93-0.96) for 2 g/day increment in cereal fiber intake. Findings from this meta-analysis indicate that the intakes of dietary fiber may be inversely associated with risk of type 2 diabetes.
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- Authors
- Yao, B., Fang, H., Xu, W., Yan, Y., Xu, H., Liu, Y., Mo, M., Zhang, H., & Zhao, Y.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Zhao, Yanping
- Venue
- European Journal of Epidemiology
- Published
- 2014-01-05
- Volume
- 29
- Issue
- 2
- Pages
- 79-88
- ISSN
- 0393-2990 (ISSN-L)
- 1573-7284
- OpenAlex
- W2083323956
- Cited by
- 281
- References
- 48
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 19 · 2023: 22 · 2022: 31 · 2021: 24 · 2020: 33 · 2019: 29 · 2018: 32 · 2017: 31 · 2016: 18 · 2015: 11 · 2014: 7
- FWCI
- 20.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- dietary fiber, type 2 diabetes, cereal fiber, fruit fiber, insoluble dietary fiber, dose-response relationship, nonlinear relationship, diabetes risk, prospective cohort
- MeSH terms
- Edible Grain, Diabetes Mellitus, Type 2, Diet, Dietary Fiber, Dose-Response Relationship, Drug, Female, Fruit, Humans, Male, Prospective Studies, Risk Factors, Vegetables
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