The Gut Microbiota-Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
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Currently, there is an increasing number of people with mild cognitive (MCI) impairment and dementia (D). In the present work we studied the role of tau protein, β-amyloid, LPS (lipopolysaccharide), and curli protein of elderly adults with MCI or D and the contribution of gut microbiota. Four groups were studied: young subjects, healthy adults older than 60 years (A), elderly adults with MCI (MCI), and elderly adults with dementia (D). A preclinical study was conducted in old male Wistar rats to evaluate the impact of gut microbiota on curli protein abundance in feces and brain. The results showed that with increasing age, tau protein, β-amyloid, and LPS significantly increased in serum during MCI and D, and this was associated with an increase in the abundance of E. coli that synthesize the amyloid protein curli, that may promote the aggregation of amyloid proteins. Rats showed a clear increase in the abundance of curli protein in the brain during aging. Thus, cognitive impairment and dementia are in part due to an alteration in the gut microbiota–brain axis via increase in curli protein and LPS leading to an increase in tau and β-amyloid protein.
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LPS is elevated in both the blood and brain of AD patients.
“LPS is elevated in both the blood and brain of AD patients.25–29”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [29]
Results §3.2 and the Discussion report substantially higher serum LPS in the dementia group than in healthy controls, supporting the blood portion of the claim. Methods §2.7 says LPS was measured in serum; the paper does not report elevated LPS in patients’ brains. Its studied group is described as having dementia, not specifically diagnosed AD. (LLM, conf=0.88)
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- Authors
- Sánchez-Tapia, M., Mimenza-Alvarado, A., Granados-Domínguez, L., Flores-López, A., López-Barradas, A., Ortiz, V., Pérez-Cruz, C., Sánchez-Vidal, H., Hernández-Acosta, J., Ávila-Funes, J. A., Guevara-Cruz, M., Tovar, A. R., & Torres, N.
- Affiliations
- Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Laboratorio de Neuroplasticidad y Neurodegeneración, Departamento de Farmacología, CINVESTAV, Mexico City 07360, Mexico
- Departamento de Geriatria, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico
- Corresponding author
- Torres, Nimbe
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2023-02-13
- Volume
- 15
- Issue
- 4
- Pages
- 932
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC9961602
- OpenAlex
- W4320497552
- Cited by
- 47
- References
- 28
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 14 · 2023: 2
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- gut-brain axis, aging, mild cognitive impairment, dementia, tau protein, amyloid-beta, lipopolysaccharide, Escherichia coli, amyloid fibril formation, serum biomarkers, fecal microbiota, brain amyloid, cognitive impairment
- MeSH terms
- Gastrointestinal Microbiome, Aging, Alzheimer Disease, Animals, Brain, Escherichia coli, Feces, Lipopolysaccharides, Male, Amyloid beta-Peptides, Rats, Wistar, Rats, Cognitive Dysfunction
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