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Cited by 144Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

The effects of gut microbiota on CNS function in humans

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Tillisch, Kirsten·2014·Gut Microbes
DOI 10.4161/gmic.29232PMC PMC4153780
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Abstract

The role of the gastrointestinal microbiota in human brain development and function is an area of increasing interest and research. Preclinical models suggest a role for the microbiota in broad aspects of human health, including mood, cognition, and chronic pain. Early human studies suggest that altering the microbiota with beneficial bacteria, or probiotics, can lead to changes in brain function, as well as subjective reports of mood. As the mechanisms of bidirectional communication between the brain and microbiota are better understood, it is expected that these pathways will be harnessed to provide novel methods to enhance health and treat disease.

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  • The gut microbiome and the brain are strongly linked, influencing brain growth and development.

    “The gut microbiome and the brain are strongly linked, influencing brain growth and development [9,10].”

    From Effect of Supplementation with Probiotics in Patients with Schizophrenia: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials (2025) · cites this paper as [9]

    The Introduction describes bidirectional communication between the gut microbiota and brain and says the microbiota may influence brain development. It presents that developmental influence as a possibility, supported in part by rodent studies, rather than an established effect on human brain growth and development. (LLM, conf=0.84)

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References 76 · Cited by 144

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  1. [1]Jiménez E, Fernández L, Marín ML, Martín R, Odriozola JM, Nueno-Palop C, Narbad A, Olivares M, Xaus J, Rodríguez JM. Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section. Curr Microbiol. 2005;51:270–4. doi: 10.1007/s00284-005-0020-3. [DOI] [PubMed] [Google Scholar] · DOI
  2. [2]Wagner CL, Taylor SN, Johnson D. Host factors in amniotic fluid and breast milk that contribute to gut maturation. Clin Rev Allergy Immunol. 2008;34:191–204. doi: 10.1007/s12016-007-8032-3. [DOI] [PubMed] [Google Scholar] · DOI
  3. [3]Satokari R, Grönroos T, Laitinen K, Salminen S, Isolauri E. Bifidobacterium and Lactobacillus DNA in the human placenta. Lett Appl Microbiol. 2009;48:8–12. doi: 10.1111/j.1472-765X.2008.02475.x. [DOI] [PubMed] [Google Scholar] · DOI
  4. [4]Al-Asmakh M, Anuar F, Zadjali F, Rafter J, Pettersson S. Gut microbial communities modulating brain development and function. Gut Microbes. 2012;3:366–73. doi: 10.4161/gmic.21287. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  5. [5]Azad MB, Konya T, Maughan H, Guttman DS, Field CJ, Chari RS, Sears MR, Becker AB, Scott JA, Kozyrskyj AL, CHILD Study Investigators Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ. 2013;185:385–94. doi: 10.1503/cmaj.121189. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  6. [6]Penders J, Thijs C, Vink C, Stelma FF, Snijders B, Kummeling I, van den Brandt PA, Stobberingh EE. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006;118:511–21. doi: 10.1542/peds.2005-2824. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  7. [7]Butel MJ, Suau A, Campeotto F, Magne F, Aires J, Ferraris L, Kalach N, Leroux B, Dupont C. Conditions of bifidobacterial colonization in preterm infants: a prospective analysis. J Pediatr Gastroenterol Nutr. 2007;44:577–82. doi: 10.1097/MPG.0b013e3180406b20. [DOI] [PubMed] [Google Scholar] · DOI
  8. [8]Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, Angenent LT, Ley RE. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A. 2011;108(Suppl 1):4578–85. doi: 10.1073/pnas.1000081107. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  9. [9]Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, et al. Human gut microbiome viewed across age and geography. Nature. 2012;486:222–7. doi: 10.1038/nature11053. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  10. [10]Mischke M, Plösch T. More than just a gut instinct-the potential interplay between a baby’s nutrition, its gut microbiome, and the epigenome. Am J Physiol Regul Integr Comp Physiol. 2013;304:R1065–9. doi: 10.1152/ajpregu.00551.2012. [DOI] [PubMed] [Google Scholar] · DOI
  11. [11]Weaver IC. Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let’s call the whole thing off. Epigenetics. 2007;2:22–8. doi: 10.4161/epi.2.1.3881. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  12. [12]Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol. 2004;558:263–75. doi: 10.1113/jphysiol.2004.063388. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  13. [14]Holmes E, Kinross J, Gibson GR, Burcelin R, Jia W, Pettersson S, Nicholson JK. Therapeutic modulation of microbiota-host metabolic interactions. Sci Transl Med. 2012;4:rv6. doi: 10.1126/scitranslmed.3004244. [DOI] [PubMed] [Google Scholar] · DOI
  14. [15]Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S. Host-gut microbiota metabolic interactions. Science. 2012;336:1262–7. doi: 10.1126/science.1223813. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  15. [17]Montiel-Castro AJ, González-Cervantes RM, Bravo-Ruiseco G, Pacheco-López G. The microbiota-gut-brain axis: neurobehavioral correlates, health and sociality. Front Integr Neurosci. 2013;7:70. doi: 10.3389/fnint.2013.00070. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  16. [18]Berntson GG, Sarter M, Cacioppo JT. Ascending visceral regulation of cortical affective information processing. Eur J Neurosci. 2003;18:2103–9. doi: 10.1046/j.1460-9568.2003.02967.x. [DOI] [PubMed] [Google Scholar] · DOI
  17. [20]Marshall JK, Thabane M, Garg AX, Clark WF, Salvadori M, Collins SM, Walkerton Health Study Investigators Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery. Gastroenterology. 2006;131:445–50, quiz 660. doi: 10.1053/j.gastro.2006.05.053. [DOI] [PubMed] [Google Scholar] · DOI
  18. [21]Goehler LE, Gaykema RP, Opitz N, Reddaway R, Badr N, Lyte M. Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni. Brain Behav Immun. 2005;19:334–44. doi: 10.1016/j.bbi.2004.09.002. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  19. [23]Gaykema RP, Goehler LE, Lyte M. Brain response to cecal infection with Campylobacter jejuni: analysis with Fos immunohistochemistry. Brain Behav Immun. 2004;18:238–45. doi: 10.1016/j.bbi.2003.08.002. [DOI] [PubMed] [Google Scholar] · DOI
  20. [24]Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, Huang X, Deng Y, Blennerhassett PA, Fahnestock M, Moine D, et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil. 2011;23:1132–9. doi: 10.1111/j.1365-2982.2011.01796.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  21. [25]Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, Deng Y, Blennerhassett P, Macri J, McCoy KD, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology. 2011;141:599–609, e1-3. doi: 10.1053/j.gastro.2011.04.052. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  22. [26]Banks WA, Kastin AJ, Broadwell RD. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation. 1995;2:241–8. doi: 10.1159/000097202. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  23. [27]Kelley KW, Bluthé RM, Dantzer R, Zhou JH, Shen WH, Johnson RW, Broussard SR. Cytokine-induced sickness behavior. Brain Behav Immun. 2003;17(Suppl 1):S112–8. doi: 10.1016/S0889-1591(02)00077-6. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  24. [28]Ulluwishewa D, Anderson RC, McNabb WC, Moughan PJ, Wells JM, Roy NC. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr. 2011;141:769–76. doi: 10.3945/jn.110.135657. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  25. [32]Ewaschuk JB, Diaz H, Meddings L, Diederichs B, Dmytrash A, Backer J, Looijer-van Langen M, Madsen KL. Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Am J Physiol Gastrointest Liver Physiol. 2008;295:G1025–34. doi: 10.1152/ajpgi.90227.2008. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  26. [33]O’Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, O’Sullivan GC, Kiely B, Collins JK, Shanahan F, et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology. 2005;128:541–51. doi: 10.1053/j.gastro.2004.11.050. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  27. [34]Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut. 2007;56:1522–8. doi: 10.1136/gut.2006.117176. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  28. [35]Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, Houdeau E, Fioramonti J, Bueno L, Theodorou V. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology. 2012;37:1885–95. doi: 10.1016/j.psyneuen.2012.03.024. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  29. [37]Messaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes. 2011;2:256–61. doi: 10.4161/gmic.2.4.16108. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  30. [38]Thomas CM, Hong T, van Pijkeren JP, Hemarajata P, Trinh DV, Hu W, Britton RA, Kalkum M, Versalovic J. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS One. 2012;7:e31951. doi: 10.1371/journal.pone.0031951. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  31. [39]Asano Y, Hiramoto T, Nishino R, Aiba Y, Kimura T, Yoshihara K, Koga Y, Sudo N. Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice. Am J Physiol Gastrointest Liver Physiol. 2012;303:G1288–95. doi: 10.1152/ajpgi.00341.2012. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  32. [40]Barrett E, Ross RP, O’Toole PW, Fitzgerald GF, Stanton C. γ-Aminobutyric acid production by culturable bacteria from the human intestine. J Appl Microbiol. 2012;113:411–7. doi: 10.1111/j.1365-2672.2012.05344.x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  33. [41]Uribe A, Alam M, Johansson O, Midtvedt T, Theodorsson E. Microflora modulates endocrine cells in the gastrointestinal mucosa of the rat. Gastroenterology. 1994;107:1259–69. doi: 10.1016/0016-5085(94)90526-6. [DOI] [PubMed] [Google Scholar] · DOI
  34. [42]Butterworth RF. The liver-brain axis in liver failure: neuroinflammation and encephalopathy. Nat Rev Gastroenterol Hepatol. 2013;10:522–8. doi: 10.1038/nrgastro.2013.99. [DOI] [PubMed] [Google Scholar] · DOI
  35. [43]Lesniewska V, Rowland I, Cani PD, Neyrinck AM, Delzenne NM, Naughton PJ. Effect on components of the intestinal microflora and plasma neuropeptide levels of feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and inulin to adult and elderly rats. Appl Environ Microbiol. 2006;72:6533–8. doi: 10.1128/AEM.00915-06. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  36. [44]Holmes E, Li JV, Marchesi JR, Nicholson JK. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metab. 2012;16:559–64. doi: 10.1016/j.cmet.2012.10.007. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  37. [45]Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG. The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat. J Psychiatr Res. 2008;43:164–74. doi: 10.1016/j.jpsychires.2008.03.009. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  38. [48]Martin FP, Rezzi S, Peré-Trepat E, Kamlage B, Collino S, Leibold E, Kastler J, Rein D, Fay LB, Kochhar S. Metabolic effects of dark chocolate consumption on energy, gut microbiota, and stress-related metabolism in free-living subjects. J Proteome Res. 2009;8:5568–79. doi: 10.1021/pr900607v. [DOI] [PubMed] [Google Scholar] · DOI
  39. [49]Pase MP, Scholey AB, Pipingas A, Kras M, Nolidin K, Gibbs A, Wesnes K, Stough C. Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial. J Psychopharmacol. 2013;27:451–8. doi: 10.1177/0269881112473791. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  40. [50]Parker G, Parker I, Brotchie H. Mood state effects of chocolate. J Affect Disord. 2006;92:149–59. doi: 10.1016/j.jad.2006.02.007. [DOI] [PubMed] [Google Scholar] · DOI
  41. [52]Marteau P, Guyonnet D, Lafaye de Micheaux P, Gelu S. A randomized, double-blind, controlled study and pooled analysis of two identical trials of fermented milk containing probiotic Bifidobacterium lactis CNCM I-2494 in healthy women reporting minor digestive symptoms. Neurogastroenterol Motil. 2013;25:331–e252. doi: 10.1111/nmo.12078. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  42. [53]Whorwell PJ, Altringer L, Morel J, Bond Y, Charbonneau D, O’Mahony L, Kiely B, Shanahan F, Quigley EM. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol. 2006;101:1581–90. doi: 10.1111/j.1572-0241.2006.00734.x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  43. [55]Benedetti F, Mayberg HS, Wager TD, Stohler CS, Zubieta JK. Neurobiological mechanisms of the placebo effect. J Neurosci. 2005;25:10390–402. doi: 10.1523/JNEUROSCI.3458-05.2005. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  44. [56]Keita AV, Söderholm JD. The intestinal barrier and its regulation by neuroimmune factors. Neurogastroenterol Motil. 2010;22:718–33. doi: 10.1111/j.1365-2982.2010.01498.x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  45. [57]Schreiber KL, Brown DR. Adrenocorticotrophic hormone modulates Escherichia coli O157:H7 adherence to porcine colonic mucosa. Stress. 2005;8:185–90. doi: 10.1080/10253890500188732. [DOI] [PubMed] [Google Scholar] · DOI
  46. [58]Spitz J, Hecht G, Taveras M, Aoys E, Alverdy J. The effect of dexamethasone administration on rat intestinal permeability: the role of bacterial adherence. Gastroenterology. 1994;106:35–41. doi: 10.1016/s0016-5085(94)94155-6. [DOI] [PubMed] [Google Scholar] · DOI
  47. [60]Bailey MT, Coe CL. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev Psychobiol. 1999;35:146–55. doi: 10.1002/(SICI)1098-2302(199909)35:2<146::AID-DEV7>3.0.CO;2-G. [DOI] [PubMed] [Google Scholar] · DOI
  48. [61]Bailey MT, Lubach GR, Coe CL. Prenatal stress alters bacterial colonization of the gut in infant monkeys. J Pediatr Gastroenterol Nutr. 2004;38:414–21. doi: 10.1097/00005176-200404000-00009. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  49. [62]O’Mahony SM, Marchesi JR, Scully P, Codling C, Ceolho AM, Quigley EM, Cryan JF, Dinan TG. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry. 2009;65:263–7. doi: 10.1016/j.biopsych.2008.06.026. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  50. [64]Sandler RH, Finegold SM, Bolte ER, Buchanan CP, Maxwell AP, Väisänen ML, Nelson MN, Wexler HM. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol. 2000;15:429–35. doi: 10.1177/088307380001500701. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  51. [65]Ming X, Stein TP, Barnes V, Rhodes N, Guo L. Metabolic perturbance in autism spectrum disorders: a metabolomics study. J Proteome Res. 2012;11:5856–62. doi: 10.1021/pr300910n. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  52. [66]De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti DI, Cristofori F, Guerzoni ME, Gobbetti M, Francavilla R. Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. PLoS One. 2013;8:e76993. doi: 10.1371/journal.pone.0076993. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  53. [68]Finegold SM, Molitoris D, Song Y, Liu C, Vaisanen ML, Bolte E, McTeague M, Sandler R, Wexler H, Marlowe EM, et al. Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis. 2002;35(Suppl 1):S6–16. doi: 10.1086/341914. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  54. [69]Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013;155:1451–63. doi: 10.1016/j.cell.2013.11.024. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  55. [70]Brenner SR. Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-L-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in horses. Med Hypotheses. 2013;80:103. doi: 10.1016/j.mehy.2012.10.010. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  56. [74]Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108:16050–5. doi: 10.1073/pnas.1102999108. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  57. [75]Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience. 2010;170:1179–88. doi: 10.1016/j.neuroscience.2010.08.005. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  58. [76]Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, Guyonnet D, Legrain-Raspaud S, Trotin B, Naliboff B, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology. 2013;144:1394–401, e1-4. doi: 10.1053/j.gastro.2013.02.043. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page

Authors
Tillisch, K.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Tillisch, Kirsten
ORCID
Tillisch, Kirsten
Venue
Gut Microbes
Publisher
Informa UK Limited
Published
2014-05
Volume
5
Issue
3
Pages
404-410
ISSN
  • 1949-0976 (ISSN-L)
  • 1949-0984
DOI
10.4161/gmic.29232
PMC
PMC4153780
OpenAlex
W2029736480
Cited by
144
References
76
Citations by year
2026: 6 · 2025: 9 · 2024: 10 · 2023: 7 · 2022: 16 · 2021: 13 · 2020: 18 · 2019: 15 · 2018: 15 · 2017: 13 · 2016: 14 · 2015: 6 · 2014: 2
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Gut Microbes (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut microbiota, central nervous system, brain development, gut-brain axis, probiotics, mood, cognition, chronic pain, microbiome manipulation
MeSH terms
Central Nervous System, Central Nervous System Diseases, Humans, Gastrointestinal Tract, Microbiota

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